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Home > News > Optimizing Medicinal Chemistry With Microfluidics

February 28th, 2006

Optimizing Medicinal Chemistry With Microfluidics

Ismagilov and his colleagues constructed a microfluidics device that creates discrete droplets, or plugs, of fluid that function as nanoscale chemical reactors. Each plug, containing a few hundred nanograms of a starting molecule and separated from its neighboring plugs by an inert carrier fluid, flows through the channels of a microfluidics device. There, chemical reactants are added to the plugs as they pass through T-shaped junctions joining the channels to various chemical reservoirs. Eventually, the plugs are deposited individually on a sample plate for analysis using MALDI mass spectrometry.


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