Nanotechnology Now

Our NanoNews Digest Sponsors
Heifer International



Home > Press > Tiny, Wireless, Injectable Chips Use Ultrasound to Monitor Body Processes

Chips shown in the tip of a hypodermic needle.

Chen Shi/Columbia Engineering
Chips shown in the tip of a hypodermic needle. Chen Shi/Columbia Engineering

Abstract:
Columbia Engineers develop the smallest single-chip system that is a complete functioning electronic circuit; implantable chips visible only in a microscope point the way to developing chips that can be injected into the body with a hypodermic needle to monitor medical conditions.

Tiny, Wireless, Injectable Chips Use Ultrasound to Monitor Body Processes

New York, NY | Posted on May 12th, 2021

Widely used to monitor and map biological signals, to support and enhance physiological functions, and to treat diseases, implantable medical devices are transforming healthcare and improving the quality of life for millions of people. Researchers are increasingly interested in designing wireless, miniaturized implantable medical devices for in vivo and in situ physiological monitoring. These devices could be used to monitor physiological conditions, such as temperature, blood pressure, glucose, and respiration for both diagnostic and therapeutic procedures.

To date, conventional implanted electronics have been highly volume-inefficient—they generally require multiple chips, packaging, wires, and external transducers, and batteries are often needed for energy storage. A constant trend in electronics has been tighter integration of electronic components, often moving more and more functions onto the integrated circuit itself.



Researchers at Columbia Engineering report that they have built what they say is the world's smallest single-chip system, consuming a total volume of less than 0.1 mm3. The system is as small as a dust mite and visible only under a microscope. In order to achieve this, the team used ultrasound to both power and communicate with the device wirelessly. The study was published online May 7 in Science Advances.



Chips shown in the tip of a hypodermic needle.

Chen Shi/Columbia Engineering



“We wanted to see how far we could push the limits on how small a functioning chip we could make,” said the study’s leader Ken Shepard, Lau Family professor of electrical engineering and professor of biomedical engineering. “This is a new idea of ‘chip as system’—this is a chip that alone, with nothing else, is a complete functioning electronic system. This should be revolutionary for developing wireless, miniaturized implantable medical devices that can sense different things, be used in clinical applications, and eventually approved for human use.”

The team also included Elisa Konofagou, Robert and Margaret Hariri Professor of Biomedical engineering and professor of radiology, as well as Stephen A. Lee, PhD student in the Konofagou lab who assisted in the animal studies.

The design was done by doctoral student Chen Shi, who is the first author of the study. Shi’s design is unique in its volumetric efficiency, the amount of function that is contained in a given amount of volume. Traditional RF communications links are not possible for a device this small because the wavelength of the electromagnetic wave is too large relative to the size of the device. Because the wavelengths for ultrasound are much smaller at a given frequency because the speed of sound is so much less than the speed of light, the team used ultrasound to both power and communicate with the device wirelessly. They fabricated the "antenna" for communicating and powering with ultrasound directly on top of the chip.

The chip, which is the entire implantable/injectable mote with no additional packaging, was fabricated at the Taiwan Semiconductor Manufacturing Company with additional process modifications performed in the Columbia Nano Initiative cleanroom and the City University of New York Advanced Science Research Center (ASRC) Nanofabrication Facility.

Shepard commented, “This is a nice example of ‘more than Moore’ technology—we introduced new materials onto standard complementary metal-oxide-semiconductor to provide new function. In this case, we added piezoelectric materials directly onto the integrated circuit to transducer acoustic energy to electrical energy.”

Konofagou added, “Ultrasound is continuing to grow in clinical importance as new tools and techniques become available. This work continues this trend.”

The team’s goal is to develop chips that can be injected into the body with a hypodermic needle and then communicate back out of the body using ultrasound, providing information about something they measure locally. The current devices measure body temperature, but there are many more possibilities the team is working on.

####

About Columbia Engineering
Columbia Engineering, based in New York City, is one of the top engineering schools in the U.S. and one of the oldest in the nation. Also known as The Fu Foundation School of Engineering and Applied Science, the School expands knowledge and advances technology through the pioneering research of its more than 220 faculty, while educating undergraduate and graduate students in a collaborative environment to become leaders informed by a firm foundation in engineering. The School’s faculty are at the center of the University’s cross-disciplinary research, contributing to the Data Science Institute, Earth Institute, Zuckerman Mind Brain Behavior Institute, Precision Medicine Initiative, and the Columbia Nano Initiative. Guided by its strategic vision, “Columbia Engineering for Humanity,” the School aims to translate ideas into innovations that foster a sustainable, healthy, secure, connected, and creative humanity.

For more information, please click here

Contacts:
Holly Evarts
Director of Strategic Communications and Media Relations
212-854-3206 (o)
347-453-7408 (c)

Copyright © Columbia Engineering

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

About the Study

Related News Press

News and information

Brought into line: FAU physicists control the flow of electron pulses through a nanostructure channel September 24th, 2021

Nanocellulose decorated with proteins is suitable for 3D cell culturing September 24th, 2021

Development of dendritic-network-implementable artificial neurofiber transistors: Transistors with a fibrous architecture similar to those of neurons are capable of forming artificial neural networks. Fibrous networks can be used in smart wearable devices and robots September 24th, 2021

Researchers use breakthrough method to answer key question about electron states September 24th, 2021

Possible Futures

Micro-scale opto-thermo-mechanical actuation in the dry adhesive regime Peer-Reviewed Publication September 24th, 2021

MXene-GaN van der Waals metal-semiconductor junctions for high performance photodetection September 24th, 2021

Nanocellulose decorated with proteins is suitable for 3D cell culturing September 24th, 2021

Development of dendritic-network-implementable artificial neurofiber transistors: Transistors with a fibrous architecture similar to those of neurons are capable of forming artificial neural networks. Fibrous networks can be used in smart wearable devices and robots September 24th, 2021

Chip Technology

Micro-scale opto-thermo-mechanical actuation in the dry adhesive regime Peer-Reviewed Publication September 24th, 2021

Brought into line: FAU physicists control the flow of electron pulses through a nanostructure channel September 24th, 2021

Development of dendritic-network-implementable artificial neurofiber transistors: Transistors with a fibrous architecture similar to those of neurons are capable of forming artificial neural networks. Fibrous networks can be used in smart wearable devices and robots September 24th, 2021

Switching on a superfluid: Exotic phase transitions unlock pathways to future, superfluid-based technologies September 24th, 2021

Nanomedicine

New nano particles suppress resistance to cancer immunotherapy September 17th, 2021

Getting to the root of tooth replantation challenges: Researchers from Tokyo Medical and Dental University (TMDU) report a delivery system that promotes healing in tooth replantation in rats September 17th, 2021

Engineering various sources of loss provides new features for perfect light absorption: "Loss is ubiquitous in nature, and by better understanding it, we make it more useful" September 10th, 2021

Leibniz Prize winner Professor Dr. Oliver G. Schmidt moves to Chemnitz University of Technology: President Professor Dr. Gerd Strohmeier refers to an 'absolute top transfer' September 10th, 2021

Discoveries

Fabricating MgB2 superconductors using spark plasma sintering and pulse magnetization: New research suggests that highly dense MgB2 bulks have improved mechanical and superconducting properties September 24th, 2021

Brought into line: FAU physicists control the flow of electron pulses through a nanostructure channel September 24th, 2021

Nanocellulose decorated with proteins is suitable for 3D cell culturing September 24th, 2021

Researchers use breakthrough method to answer key question about electron states September 24th, 2021

Announcements

Brought into line: FAU physicists control the flow of electron pulses through a nanostructure channel September 24th, 2021

Nanocellulose decorated with proteins is suitable for 3D cell culturing September 24th, 2021

Development of dendritic-network-implementable artificial neurofiber transistors: Transistors with a fibrous architecture similar to those of neurons are capable of forming artificial neural networks. Fibrous networks can be used in smart wearable devices and robots September 24th, 2021

Researchers use breakthrough method to answer key question about electron states September 24th, 2021

Interviews/Book Reviews/Essays/Reports/Podcasts/Journals/White papers/Posters

Micro-scale opto-thermo-mechanical actuation in the dry adhesive regime Peer-Reviewed Publication September 24th, 2021

MXene-GaN van der Waals metal-semiconductor junctions for high performance photodetection September 24th, 2021

Fabricating MgB2 superconductors using spark plasma sintering and pulse magnetization: New research suggests that highly dense MgB2 bulks have improved mechanical and superconducting properties September 24th, 2021

Brought into line: FAU physicists control the flow of electron pulses through a nanostructure channel September 24th, 2021

Battery Technology/Capacitors/Generators/Piezoelectrics/Thermoelectrics/Energy storage

Stretching the capacity of flexible energy storage September 10th, 2021

Polymer electrolytes for all-solid-state batteries without dead zones August 20th, 2021

Researchers discover a new inorganic material with lowest thermal conductivity ever reported July 16th, 2021

Proliferation of electric vehicles based on high-performance, low-cost sodium-ion battery:A large-capacity anode material is developed for sodium-ion batteries by using low-cost silicone-based oil. This process, if commercialized, is expected to significantly reduce manufacturing June 18th, 2021

Nanobiotechnology

New nano particles suppress resistance to cancer immunotherapy September 17th, 2021

Getting to the root of tooth replantation challenges: Researchers from Tokyo Medical and Dental University (TMDU) report a delivery system that promotes healing in tooth replantation in rats September 17th, 2021

Leibniz Prize winner Professor Dr. Oliver G. Schmidt moves to Chemnitz University of Technology: President Professor Dr. Gerd Strohmeier refers to an 'absolute top transfer' September 10th, 2021

Imaging single spine structural plasticity at the nanoscale level: Researchers at the Max Planck Florida Institute for Neuroscience (MPFI) have developed a new imaging technique capable of visualizing the dynamically changing structure of dendritic spines with unprecedented resol September 3rd, 2021

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project