Nanotechnology Now

Our NanoNews Digest Sponsors
Heifer International



Home > Press > Pioneering new technique could revolutionise super-resolution imaging systems

Abstract:
Scientists have developed a pioneering new technique that could revolutionise the accuracy, precision and clarity of super-resolution imaging systems.

Pioneering new technique could revolutionise super-resolution imaging systems

Exeter, UK | Posted on January 22nd, 2021

A team of scientists, led by Dr Christian Soeller from the University of Exeter's Living Systems Institute, which champions interdisciplinary research and is a hub for new high-resolution measurement techniques, has developed a new way to improve the very fine, molecular imaging of biological samples.

The new method builds upon the success of an existing super-resolution imaging technique called DNA-PAINT (Point Accumulation for Imaging in Nanoscale Topography) - where molecules in a cell are labelled with marker molecules that are attached to single DNA strands.

Matching DNA strands are then also labelled with a florescent chemical compound and introduced in solution - when they bind the marker molecules, it creates a 'blinking effect' that makes imaging possible.

However, DNA-PAINT has a number of drawbacks in its current form, which limit the applicability and performance of the technology when imaging biological cells and tissues.

In response, the research team have developed a new technique, called Repeat DNA-Paint, which is capable of supressing background noise and nonspecific signals, as well as decreasing the time taken for the sampling process.

Crucially, using Repeat DNA-PAINT is straightforward and does not carry any known drawbacks, it is routinely applicable, consolidating the role of DNA-PAINT as one of the most robust and versatile molecular resolution imaging methods.

The study is published in Nature Communications on 21st January 2021 .

Dr Soeller, lead author of the study and who is a biophysicist at the Living Systems Institute said: "We can now see molecular detail with light microscopy in a way that a few years ago seemed out of reach. This allows us to directly see how molecules orchestrate the intricate biological functions that enable life in both health and disease".

The research was enabled by colleagues from physics, biology, medicine, mathematics and chemistry working together across traditional discipline boundaries. Dr Lorenzo Di Michele, co-author from Imperial College London said: "This work is a clear example of how quantitative biophysical techniques and concepts can really improve our ability to study biological systems".

####

For more information, please click here

Contacts:
Duncan Sandes

44-013-927-22391

@uniofexeter

Copyright © University of Exeter

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

RELATED JOURNAL ARTICLE:

Related News Press

News and information

Researchers develop artificial building blocks of life March 8th, 2024

How surface roughness influences the adhesion of soft materials: Research team discovers universal mechanism that leads to adhesion hysteresis in soft materials March 8th, 2024

Two-dimensional bimetallic selenium-containing metal-organic frameworks and their calcinated derivatives as electrocatalysts for overall water splitting March 8th, 2024

Curcumin nanoemulsion is tested for treatment of intestinal inflammation: A formulation developed by Brazilian researchers proved effective in tests involving mice March 8th, 2024

Imaging

Nanoscale CL thermometry with lanthanide-doped heavy-metal oxide in TEM March 8th, 2024

First direct imaging of small noble gas clusters at room temperature: Novel opportunities in quantum technology and condensed matter physics opened by noble gas atoms confined between graphene layers January 12th, 2024

The USTC realizes In situ electron paramagnetic resonance spectroscopy using single nanodiamond sensors November 3rd, 2023

Observation of left and right at nanoscale with optical force October 6th, 2023

Possible Futures

Two-dimensional bimetallic selenium-containing metal-organic frameworks and their calcinated derivatives as electrocatalysts for overall water splitting March 8th, 2024

Curcumin nanoemulsion is tested for treatment of intestinal inflammation: A formulation developed by Brazilian researchers proved effective in tests involving mice March 8th, 2024

The Access to Advanced Health Institute receives up to $12.7 million to develop novel nanoalum adjuvant formulation for better protection against tuberculosis and pandemic influenza March 8th, 2024

Nanoscale CL thermometry with lanthanide-doped heavy-metal oxide in TEM March 8th, 2024

Discoveries

What heat can tell us about battery chemistry: using the Peltier effect to study lithium-ion cells March 8th, 2024

Researchers’ approach may protect quantum computers from attacks March 8th, 2024

High-tech 'paint' could spare patients repeated surgeries March 8th, 2024

Nanoscale CL thermometry with lanthanide-doped heavy-metal oxide in TEM March 8th, 2024

Announcements

What heat can tell us about battery chemistry: using the Peltier effect to study lithium-ion cells March 8th, 2024

Curcumin nanoemulsion is tested for treatment of intestinal inflammation: A formulation developed by Brazilian researchers proved effective in tests involving mice March 8th, 2024

The Access to Advanced Health Institute receives up to $12.7 million to develop novel nanoalum adjuvant formulation for better protection against tuberculosis and pandemic influenza March 8th, 2024

Nanoscale CL thermometry with lanthanide-doped heavy-metal oxide in TEM March 8th, 2024

Interviews/Book Reviews/Essays/Reports/Podcasts/Journals/White papers/Posters

Researchers develop artificial building blocks of life March 8th, 2024

How surface roughness influences the adhesion of soft materials: Research team discovers universal mechanism that leads to adhesion hysteresis in soft materials March 8th, 2024

Curcumin nanoemulsion is tested for treatment of intestinal inflammation: A formulation developed by Brazilian researchers proved effective in tests involving mice March 8th, 2024

Nanoscale CL thermometry with lanthanide-doped heavy-metal oxide in TEM March 8th, 2024

Photonics/Optics/Lasers

Nanoscale CL thermometry with lanthanide-doped heavy-metal oxide in TEM March 8th, 2024

Optically trapped quantum droplets of light can bind together to form macroscopic complexes March 8th, 2024

HKUST researchers develop new integration technique for efficient coupling of III-V and silicon February 16th, 2024

A battery’s hopping ions remember where they’ve been: Seen in atomic detail, the seemingly smooth flow of ions through a battery’s electrolyte is surprisingly complicated February 16th, 2024

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project