Nanotechnology Now

Our NanoNews Digest Sponsors
Heifer International

Wikipedia Affiliate Button

Home > Press > Gold nanoclusters: new frontier for developing medication for treatment of Alzheimer's disease

Au23(CR)14 Nanocluster functions in multiple stages of the progression from Aβ monomer to Aβ plaques.

CREDIT
İScience China Press
Au23(CR)14 Nanocluster functions in multiple stages of the progression from Aβ monomer to Aβ plaques. CREDIT İScience China Press

Abstract:
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by amyloid-β (Aβ) fibrillation and plaque formation. While more than 50 millions of people are devastated by AD, no treatment is available. Recently, anti-Aβ antibody-based immunotherapy has failed in clinical trials, partially due to the increased cytotoxicity of soluble Aβ oligomers. Therefore, developing a medication for AD treatment becomes an even more grave challenge.

Gold nanoclusters: new frontier for developing medication for treatment of Alzheimer's disease

Beijing, China | Posted on February 14th, 2020

In a new research article published in the Beijing-based National Science Review, scientists at the State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology in China explored the possibility of treating with gold nanoclusters.

As illustrated in Figure 1, Au23(CR)14, a novel gold nanocluster modified with Cys-Arg (CR) dipeptide, functions in multiple stages of the progression from Aβ monomer to Aβ plaques: inhibiting the misfolding and fibrillation of amyloid-β (Aβ), fully dissolving the preformed/mature Aβ fibrils and restoring the conformation of Aβ peptides from misfolded β-sheets into unfolded monomer state with abolished cytotoxicity, and more importantly, completely dissolving endogenous Aβ plaques in the brain slices from transgenic AD model mice. Furthermore, Au23(CR)14 has good biocompatibility and infiltration ability across the blood brain barrier (BBB).

This article not only presents a compelling nanotherapeutic candidate for AD treatment, but also opens a new frontier for developing nanomaterial-based medications for AD treatment. Undoubtedly, more researches studying the basic mechanisms by which gold nanoclusters dissolve Aβ plaques will spur the development of new medications for AD treatment.

###

This research received funding from the National Natural Science Foundation of China (21975191, 21805218, 51873168, 81803515, 51533007 and 51521001) and the Natural Science Foundation of Hubei Province (2018CFA002 and 2018CFB348).

####

About Science China Press
The National Science Review is the first comprehensive scholarly journal released in English in China that is aimed at linking the country's rapidly advancing community of scientists with the global frontiers of science and technology. The journal also aims to shine a worldwide spotlight on scientific research advances across China.

For more information, please click here

Contacts:
Taolei Sun

Copyright © Science China Press

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

See the article:

Related News Press

News and information

Researchers show what drives a novel, ordered assembly of alternating peptides February 20th, 2020

CEA-Leti and CEA-IRIG Demonstrate Quantum Integrated Circuit Combining Quantum Dot with Digital-Analog Circuits on CMOS Chip: Presentation at ISSCC 2020 Shows Role FD-SOI Can Play in Embedding Qubit Arrays with Classic Electronics to Build Large-Scale Quantum Silicon Processors February 20th, 2020

CEA-Leti Presents High-Performance Processor Breakthrough With Active Interposer and 3D Stacked Chiplets at ISSCC 2020 February 19th, 2020

New green technology from UMass Amherst generates electricity 'out of thin air' Renewable device could help mitigate climate change, power medical devices February 17th, 2020

Possible Futures

Researchers show what drives a novel, ordered assembly of alternating peptides February 20th, 2020

CEA-Leti and CEA-IRIG Demonstrate Quantum Integrated Circuit Combining Quantum Dot with Digital-Analog Circuits on CMOS Chip: Presentation at ISSCC 2020 Shows Role FD-SOI Can Play in Embedding Qubit Arrays with Classic Electronics to Build Large-Scale Quantum Silicon Processors February 20th, 2020

CEA-Leti Presents High-Performance Processor Breakthrough With Active Interposer and 3D Stacked Chiplets at ISSCC 2020 February 19th, 2020

New green technology from UMass Amherst generates electricity 'out of thin air' Renewable device could help mitigate climate change, power medical devices February 17th, 2020

Nanomedicine

Novel formulation permits use of toxin from rattlesnake venom to treat chronic pain: Researchers Butantan Institute succeeded in reducing the toxicity and potentiating the analgesic effect of crotoxin by encapsulating it in nanostructured silica -- the results of tests in an anim February 14th, 2020

Nanotech company granted FDA Fast Track for treatment of head & neck cancer February 10th, 2020

Arrowhead Reports Interim Clinical Data on Cardiometabolic Candidates ARO-APOC3 and ARO-ANG3 February 5th, 2020

How to keep boron inside cells during radiotherapy: a simple novel approach to cancer treatment January 24th, 2020

Discoveries

Researchers show what drives a novel, ordered assembly of alternating peptides February 20th, 2020

New green technology from UMass Amherst generates electricity 'out of thin air' Renewable device could help mitigate climate change, power medical devices February 17th, 2020

Does graphene cause or prevent the corrosion of copper? New study finally settles the debate: Scientists in Korea are first to observe an unprecedented way in which graphene forms a hybrid layer that prevents copper corrosion February 14th, 2020

KIST unveils the mystery of van der Waals magnets, a material for future semiconductors: Overcoming the limits of current magnetic materials, giving hope for development of next-generation semiconductors February 14th, 2020

Announcements

CEA-Leti and CEA-IRIG Demonstrate Quantum Integrated Circuit Combining Quantum Dot with Digital-Analog Circuits on CMOS Chip: Presentation at ISSCC 2020 Shows Role FD-SOI Can Play in Embedding Qubit Arrays with Classic Electronics to Build Large-Scale Quantum Silicon Processors February 20th, 2020

CEA-Leti Presents High-Performance Processor Breakthrough With Active Interposer and 3D Stacked Chiplets at ISSCC 2020 February 19th, 2020

New green technology from UMass Amherst generates electricity 'out of thin air' Renewable device could help mitigate climate change, power medical devices February 17th, 2020

KIST unveils the mystery of van der Waals magnets, a material for future semiconductors: Overcoming the limits of current magnetic materials, giving hope for development of next-generation semiconductors February 14th, 2020

Interviews/Book Reviews/Essays/Reports/Podcasts/Journals/White papers/Posters

Researchers show what drives a novel, ordered assembly of alternating peptides February 20th, 2020

New green technology from UMass Amherst generates electricity 'out of thin air' Renewable device could help mitigate climate change, power medical devices February 17th, 2020

Does graphene cause or prevent the corrosion of copper? New study finally settles the debate: Scientists in Korea are first to observe an unprecedented way in which graphene forms a hybrid layer that prevents copper corrosion February 14th, 2020

KIST unveils the mystery of van der Waals magnets, a material for future semiconductors: Overcoming the limits of current magnetic materials, giving hope for development of next-generation semiconductors February 14th, 2020

Nanobiotechnology

Novel formulation permits use of toxin from rattlesnake venom to treat chronic pain: Researchers Butantan Institute succeeded in reducing the toxicity and potentiating the analgesic effect of crotoxin by encapsulating it in nanostructured silica -- the results of tests in an anim February 14th, 2020

Nanotech company granted FDA Fast Track for treatment of head & neck cancer February 10th, 2020

Arrowhead Reports Interim Clinical Data on Cardiometabolic Candidates ARO-APOC3 and ARO-ANG3 February 5th, 2020

How to keep boron inside cells during radiotherapy: a simple novel approach to cancer treatment January 24th, 2020

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project