Nanotechnology Now

Our NanoNews Digest Sponsors
Heifer International

Wikipedia Affiliate Button

Home > Press > Molecular factories: The combination between nature and chemistry is functional

In molecular factories injected into zebrafish embryos, a colour reaction occurs when the trapped enzyme (peroxidase) is working. The researchers thus prove that the combination of synthetic organelles and natural vesicles also works in the living organism.
In molecular factories injected into zebrafish embryos, a colour reaction occurs when the trapped enzyme (peroxidase) is working. The researchers thus prove that the combination of synthetic organelles and natural vesicles also works in the living organism.

Abstract:
Researchers at the University of Basel have succeeded in developing molecular factories that mimic nature. To achieve this they loaded artificial organelles inside micrometer-sized natural blisters (vesicles) produced by cells. These molecular factories remain intact even after injection into an animal model and demonstrate no toxicity, as the team report in the scientific journal Advanced Science.

In molecular factories injected into zebrafish embryos, a color reaction occurs when the trapped enzyme (peroxidase) is working. The researchers thus prove that the combination of synthetic organelles and natural vesicles also works in the living organism.

CREDIT University of Basel

Molecular factories: The combination between nature and chemistry is functional

Basel, Switzerland | Posted on January 10th, 2020

Within the cells, the actual biological factories, the molecules of life are assembled. The assembly lines of cells are small compartments called organelles, where a large variety of chemical reactions take place either inside or between them. For medical applications, molecular factories acting as artificial cells would ideally beused - to produce missing or required molecules or drugs.

Soft, synthetic capsules

Collaboration between the Department of Chemistry at the University of Basel, the Swiss Nanoscience Institute, and the NCCR Molecular Systems Engineering made the successful development of such molecular factories possible. First, researchers led by Professor Cornelia Palivan and Professor Wolfgang Meier designed artificial organelles, that is distinct compartments of cells. They loaded these soft, synthetic capsules with enzymes and equipped them with membrane proteins that act like "gates". These gates allow molecules involved in the enzymatic reaction to enter and leave the capsule.

Subsequently, the natural cells were feed with these artificial organelles. After stimulation, the cells produced natural micrometer-size vesicles. These possess a natural cell membrane and cytoplasm, enclose the artificial organelles and can therefore function as a molecular factory.

Zebra fish embryos as an animal model

The molecular factories were injected into zebra fish embryos by researchers from the group led by Professor Jörg Huwyler (Pharmazentrum of the University of Basel). In this animal model, they produced the desired compound, which was catalyzed by the enzyme in the artificial organelle. The viability of the animal was not compromised by the injection.

"This combination of natural vesicles and small synthetic organelles is what makes the molecular factory: Reactions that take place inside produce an end product, as also happens inside cells," explain Dr. Tomaz Einfalt and Dr. Martina Garni, first authors of the paper.

Within the molecular factories, multiple components can be made and assembled into the end product. The biosynthetic vesicles can also transfer components from one cell to the other. Different molecular factories can be combined so that complex structures with high functionality can be created - the first step toward producing artificial cells in the laboratory or in living organisms.

####

For more information, please click here

Contacts:
Reto Caluori

41-612-072-495

@UniBasel_en

Copyright © University of Basel

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

RELATED JOURNAL ARTICLE:

Related News Press

News and information

Breaking the temperature barrier in small-scale materials testing February 28th, 2020

An 'exceptionally stable' single-atom catalyst: Single platinum atoms stabilized in C12A7 crystals February 26th, 2020

180 Degree Capital Corp. Reports 15.9% Annual Increase and 0.3% Quarter Increase in Net Asset Value Per Share to $3.06 as of December 31, 2019 February 24th, 2020

The Human Brain/Cloud Interface Research Paper has been Published! February 22nd, 2020

Chemistry

An 'exceptionally stable' single-atom catalyst: Single platinum atoms stabilized in C12A7 crystals February 26th, 2020

Possible Futures

Breaking the temperature barrier in small-scale materials testing February 28th, 2020

An 'exceptionally stable' single-atom catalyst: Single platinum atoms stabilized in C12A7 crystals February 26th, 2020

The Human Brain/Cloud Interface Research Paper has been Published! February 22nd, 2020

KIST researchers develop high-capacity EV battery materials that double driving range: Everyday materials and simple process used to develop new battery anode materials! Cost-effectiveness and simplicity of process and excellent properties of materials enable mass-production and February 21st, 2020

Nanomedicine

A scaffold at the center of our cellular skeleton: UNIGE researchers have discovered a new nano-structure that lies at the center of our cellular skeleton; this discovery will allow to better understand how the cell maintains its architecture as well as the pathologies associated February 21st, 2020

Novel formulation permits use of toxin from rattlesnake venom to treat chronic pain: Researchers Butantan Institute succeeded in reducing the toxicity and potentiating the analgesic effect of crotoxin by encapsulating it in nanostructured silica -- the results of tests in an anim February 14th, 2020

Gold nanoclusters: new frontier for developing medication for treatment of Alzheimer's disease February 14th, 2020

Nanotech company granted FDA Fast Track for treatment of head & neck cancer February 10th, 2020

Announcements

Breaking the temperature barrier in small-scale materials testing February 28th, 2020

An 'exceptionally stable' single-atom catalyst: Single platinum atoms stabilized in C12A7 crystals February 26th, 2020

180 Degree Capital Corp. Reports 15.9% Annual Increase and 0.3% Quarter Increase in Net Asset Value Per Share to $3.06 as of December 31, 2019 February 24th, 2020

The Human Brain/Cloud Interface Research Paper has been Published! February 22nd, 2020

Interviews/Book Reviews/Essays/Reports/Podcasts/Journals/White papers/Posters

Breaking the temperature barrier in small-scale materials testing February 28th, 2020

An 'exceptionally stable' single-atom catalyst: Single platinum atoms stabilized in C12A7 crystals February 26th, 2020

The Human Brain/Cloud Interface Research Paper has been Published! February 22nd, 2020

KIST researchers develop high-capacity EV battery materials that double driving range: Everyday materials and simple process used to develop new battery anode materials! Cost-effectiveness and simplicity of process and excellent properties of materials enable mass-production and February 21st, 2020

Nanobiotechnology

Novel formulation permits use of toxin from rattlesnake venom to treat chronic pain: Researchers Butantan Institute succeeded in reducing the toxicity and potentiating the analgesic effect of crotoxin by encapsulating it in nanostructured silica -- the results of tests in an anim February 14th, 2020

Gold nanoclusters: new frontier for developing medication for treatment of Alzheimer's disease February 14th, 2020

Nanotech company granted FDA Fast Track for treatment of head & neck cancer February 10th, 2020

Arrowhead Reports Interim Clinical Data on Cardiometabolic Candidates ARO-APOC3 and ARO-ANG3 February 5th, 2020

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project