Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Researchers identify cost-cutting option in treating nail fungus with nanotechnology: GW researcher Adam Friedman, M.D., studied the potential use of nitric oxide-releasing nanoparticles to improve onychomycosis treatment

Abstract:
Onychomycosis, a nail fungus that causes nail disfigurement, pain, and increased risk of soft tissue infection, impacts millions of people worldwide. There are several topical antifungal treatments currently available; however, treatment failure remains high due to a number of factors.

Researchers identify cost-cutting option in treating nail fungus with nanotechnology: GW researcher Adam Friedman, M.D., studied the potential use of nitric oxide-releasing nanoparticles to improve onychomycosis treatment

Washington, DC | Posted on July 11th, 2018

The most recent treatment, a broad spectrum triazole called efinaconazole, is designed to improve nail penetration. It boasts the highest cure rates among other topical antifungals, but the cost for a bottle is more than $600, and full treatment calls for multiple bottles.

Adam Friedman, MD, professor of dermatology at the George Washington University School of Medicine and Health Sciences, and his team investigated the use of nanotechnology to improve efinaconazole treatment and make it more cost effective. They observed that when nitric oxide-releasing nanoparticles are combined with the efinaconazole, it achieves the same antifungal effects, but at a fraction of the amount of the medication alone needed to impart the same effect.

"Nanotechnology is being studied and employed in many areas of medicine and surgery to better deliver established imaging and therapeutic agents to ultimately improve patient outcomes," said Friedman. "A quickly emerging roadblock in patient care is, unfortunately, access to medications due to rising cost and poor insurance coverage."

The study, published in the Journal of Drugs in Dermatology, found that, when combined, the nanoparticles and the medication are more effective than both alone, opening the door to potentially better and more tolerable treatment regimens. An additional benefit is the ability of nanoparticles to access infections in difficult to reach locations, as penetration and retaining activity across the nail plate is a common impediment for many antifungals.

"What we found was that we could impart the same antifungal activity at the highest concentrations tested of either alone by combining them at a fraction of these concentrations," Friedman explained. "The impact of this combo, which we visualized using electron microscopy as compared to either product alone, highlighted their synergistic damaging effects at concentrations that would be completely safe to human cells."

Given these results, the authors note that it is worth further researching the synergy of nitric oxide-releasing nanoparticles and efinaconazole against onychomycosis to determine the efficacy of the treatment in a clinical setting.

####

About George Washington University
Founded in 1824, the GW School of Medicine and Health Sciences (SMHS) was the first medical school in the nation's capital and is the 11th oldest in the country. Working together in our nation's capital, with integrity and resolve, the GW SMHS is committed to improving the health and well-being of our local, national and global communities. smhs.gwu.edu

For more information, please click here

Contacts:
Ashley Rizzardo

202-994-8679

Copyright © George Washington University

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

The study, titled "Nitric Oxide Releasing Nanoparticles as a Strategy to Improve Current Onychomycosis Treatments" is published in the Journal of Drugs in Dermatology at:

Related News Press

News and information

Optimization of alloy materials: Diffusion processes in nano particles decoded November 13th, 2018

GLOBALFOUNDRIES, indie Semiconductor Deliver Performance-Enhanced Microcontrollers for Automotive Applications: 55nm LPx platform, with SST’s highly reliable embedded SuperFlash®, increases performance and energy efficiency for automotive applications November 13th, 2018

GLOBALFOUNDRIES, indie Semiconductor Deliver Performance-Enhanced Microcontrollers for Automotive Applications: 55nm LPx platform, with SST’s highly reliable embedded SuperFlash®, increases performance and energy efficiency for automotive applications November 13th, 2018

European Commission Project Creates Pilot Line for Companies to Develop Mid-Infrared Devices: Companies Can Submit Proposals for Possible Matching Funds To Help Develop Prototypes November 13th, 2018

Possible Futures

Optimization of alloy materials: Diffusion processes in nano particles decoded November 13th, 2018

Arrowhead Pharmaceuticals Presents Late-Breaking Preliminary Clinical Data on ARO-HBV at Liver Meeting® 2018 November 9th, 2018

Unlocking the Secrets of Metal-Insulator Transitions: X-ray photon correlation spectroscopy at NSLS-II's CSX beamline used to understand electrical conductivity transitions in magnetite November 8th, 2018

WSU researchers develop new technique to understand biology at the nanoscale November 7th, 2018

Nanomedicine

Arrowhead Pharmaceuticals Presents Late-Breaking Clinical Data on ARO-AAT at Liver Meeting® 2018 November 9th, 2018

Arrowhead Pharmaceuticals Presents Late-Breaking Preliminary Clinical Data on ARO-HBV at Liver Meeting® 2018 November 9th, 2018

WSU researchers develop new technique to understand biology at the nanoscale November 7th, 2018

A record-long polymer DNA negative November 6th, 2018

Discoveries

Optimization of alloy materials: Diffusion processes in nano particles decoded November 13th, 2018

Unlocking the Secrets of Metal-Insulator Transitions: X-ray photon correlation spectroscopy at NSLS-II's CSX beamline used to understand electrical conductivity transitions in magnetite November 8th, 2018

WSU researchers develop new technique to understand biology at the nanoscale November 7th, 2018

A record-long polymer DNA negative November 6th, 2018

Announcements

Optimization of alloy materials: Diffusion processes in nano particles decoded November 13th, 2018

GLOBALFOUNDRIES, indie Semiconductor Deliver Performance-Enhanced Microcontrollers for Automotive Applications: 55nm LPx platform, with SST’s highly reliable embedded SuperFlash®, increases performance and energy efficiency for automotive applications November 13th, 2018

GLOBALFOUNDRIES, indie Semiconductor Deliver Performance-Enhanced Microcontrollers for Automotive Applications: 55nm LPx platform, with SST’s highly reliable embedded SuperFlash®, increases performance and energy efficiency for automotive applications November 13th, 2018

European Commission Project Creates Pilot Line for Companies to Develop Mid-Infrared Devices: Companies Can Submit Proposals for Possible Matching Funds To Help Develop Prototypes November 13th, 2018

Interviews/Book Reviews/Essays/Reports/Podcasts/Journals/White papers

Optimization of alloy materials: Diffusion processes in nano particles decoded November 13th, 2018

Unlocking the Secrets of Metal-Insulator Transitions: X-ray photon correlation spectroscopy at NSLS-II's CSX beamline used to understand electrical conductivity transitions in magnetite November 8th, 2018

WSU researchers develop new technique to understand biology at the nanoscale November 7th, 2018

IEDM - CEA-Leti Will Present 11 Papers and Host Workshop on Disruptive Technologies for Data Management November 7th, 2018

Nanobiotechnology

Arrowhead Pharmaceuticals Presents Late-Breaking Clinical Data on ARO-AAT at Liver Meeting® 2018 November 9th, 2018

Arrowhead Pharmaceuticals Presents Late-Breaking Preliminary Clinical Data on ARO-HBV at Liver Meeting® 2018 November 9th, 2018

WSU researchers develop new technique to understand biology at the nanoscale November 7th, 2018

A record-long polymer DNA negative November 6th, 2018

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project