Nanotechnology Now

Our NanoNews Digest Sponsors
Heifer International



Home > Press > New sensor technology enables super-sensitive live monitoring of human biomolecules

A still from the video which explains the concept. Image: ICMS Animation Studio
A still from the video which explains the concept. Image: ICMS Animation Studio

Abstract:
The human body is an extremely complex molecular machine, the details of which can be followed through certain substances; so-called biomarkers. Unfortunately, it is not yet possible to monitor biomarkers live in patients when these are present in minuscule concentrations. Researchers at Eindhoven University of Technology have now developed a new technique that can become the plain and simple solution for the live and super-sensitive monitoring of biomarkers. They report on it in Nature Communications.

New sensor technology enables super-sensitive live monitoring of human biomolecules

Eindhoven, The Netherlands | Posted on July 3rd, 2018

Substances that are essential for the body, such as proteins and hormones, are present in the blood in pico- or nanomolar concentrations. These are concentrations comparable to 1 sugar grain dissolved in an Olympic-sized swimming pool - extremely low, and difficult to measure. In the Molecular Biosensing for Medical Diagnostics group at Eindhoven University of Technology, under the guidance of Professor Menno Prins, a sensing technology has been developed that enables the super-sensitive measurement of biomarker concentrations over time.

The technique is based on the fact that tiny particles in liquid are continuously in Brownian motion because water molecules collide with them. The researchers bound the particles through a nanostrand to a glass plate, causing the particles to wiggle back and forth. The biomarker to be measured binds temporarily to specific adhesive molecules that are fixed to both the particles and the plate. When a biomarker molecule attaches itself to both a wiggling particle and to the plate, the particle suddenly becomes attached, which greatly reduces its mobility - until the biomarker is released again.

The mobility of the particles, which are coupled to the transparent glass, could be easily observed by the researchers with light. They have given their technology the name BPM: Biomarker monitoring based on sensing of Particle Mobility. Every time a wiggling particle suddenly moves less, and then more, one biomarker molecule has been observed. The number of these events per minute reveals the concentration of the biomarker in the liquid with a high degree of sensitivity.

The principle is explained in this animation video: https://www.youtube.com/watch?v=iIbmrjbw62U&feature=youtu.be

The beauty of the BPM sensor technology is that it has digital precision, and that both increases and decreases in biomarker concentration over time can be monitored. The technique has now been demonstrated for the monitoring of protein and DNA. The technology is widely applicable, because suitable adhesion molecules are available for almost all biomarkers.

This flexibility, combined with the sensitivity and the expected miniaturization of the technology, means that Prins and his fellow researchers have high expectations of the future for their technology. "We anticipate that a completely new class of sensors for the monitoring of biomarkers will emerge from this," says the professor, so he is creating a start-up that will develop practical sensors and applications. One of the possibilities is to connect a sensor to a catheter with which patients in the operating room or in the intensive care unit can be accurately monitored. In addition to medical applications, Prins also thinks there are possibilities for monitoring biomolecules in industrial processes and water purification.

####

For more information, please click here

Contacts:
Menno Prins

Copyright © Eindhoven University of Technology

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

RELATED JOURNAL ARTICLE:

Related News Press

News and information

Researchers develop artificial building blocks of life March 8th, 2024

How surface roughness influences the adhesion of soft materials: Research team discovers universal mechanism that leads to adhesion hysteresis in soft materials March 8th, 2024

Two-dimensional bimetallic selenium-containing metal-organic frameworks and their calcinated derivatives as electrocatalysts for overall water splitting March 8th, 2024

Curcumin nanoemulsion is tested for treatment of intestinal inflammation: A formulation developed by Brazilian researchers proved effective in tests involving mice March 8th, 2024

Videos/Movies

New X-ray imaging technique to study the transient phases of quantum materials December 29th, 2022

Solvent study solves solar cell durability puzzle: Rice-led project could make perovskite cells ready for prime time September 23rd, 2022

Scientists prepare for the world’s smallest race: Nanocar Race II March 18th, 2022

Visualizing the invisible: New fluorescent DNA label reveals nanoscopic cancer features March 4th, 2022

Possible Futures

Two-dimensional bimetallic selenium-containing metal-organic frameworks and their calcinated derivatives as electrocatalysts for overall water splitting March 8th, 2024

Curcumin nanoemulsion is tested for treatment of intestinal inflammation: A formulation developed by Brazilian researchers proved effective in tests involving mice March 8th, 2024

The Access to Advanced Health Institute receives up to $12.7 million to develop novel nanoalum adjuvant formulation for better protection against tuberculosis and pandemic influenza March 8th, 2024

Nanoscale CL thermometry with lanthanide-doped heavy-metal oxide in TEM March 8th, 2024

Nanomedicine

High-tech 'paint' could spare patients repeated surgeries March 8th, 2024

Researchers develop artificial building blocks of life March 8th, 2024

Curcumin nanoemulsion is tested for treatment of intestinal inflammation: A formulation developed by Brazilian researchers proved effective in tests involving mice March 8th, 2024

The Access to Advanced Health Institute receives up to $12.7 million to develop novel nanoalum adjuvant formulation for better protection against tuberculosis and pandemic influenza March 8th, 2024

Sensors

$900,000 awarded to optimize graphene energy harvesting devices: The WoodNext Foundation's commitment to U of A physicist Paul Thibado will be used to develop sensor systems compatible with six different power sources January 12th, 2024

A color-based sensor to emulate skin's sensitivity: In a step toward more autonomous soft robots and wearable technologies, EPFL researchers have created a device that uses color to simultaneously sense multiple mechanical and temperature stimuli December 8th, 2023

New tools will help study quantum chemistry aboard the International Space Station: Rochester Professor Nicholas Bigelow helped develop experiments conducted at NASA’s Cold Atom Lab to probe the fundamental nature of the world around us November 17th, 2023

TU Delft researchers discover new ultra strong material for microchip sensors: A material that doesn't just rival the strength of diamonds and graphene, but boasts a yield strength 10 times greater than Kevlar, renowned for its use in bulletproof vests November 3rd, 2023

Discoveries

What heat can tell us about battery chemistry: using the Peltier effect to study lithium-ion cells March 8th, 2024

Researchers’ approach may protect quantum computers from attacks March 8th, 2024

High-tech 'paint' could spare patients repeated surgeries March 8th, 2024

Nanoscale CL thermometry with lanthanide-doped heavy-metal oxide in TEM March 8th, 2024

Announcements

What heat can tell us about battery chemistry: using the Peltier effect to study lithium-ion cells March 8th, 2024

Curcumin nanoemulsion is tested for treatment of intestinal inflammation: A formulation developed by Brazilian researchers proved effective in tests involving mice March 8th, 2024

The Access to Advanced Health Institute receives up to $12.7 million to develop novel nanoalum adjuvant formulation for better protection against tuberculosis and pandemic influenza March 8th, 2024

Nanoscale CL thermometry with lanthanide-doped heavy-metal oxide in TEM March 8th, 2024

Interviews/Book Reviews/Essays/Reports/Podcasts/Journals/White papers/Posters

Researchers develop artificial building blocks of life March 8th, 2024

How surface roughness influences the adhesion of soft materials: Research team discovers universal mechanism that leads to adhesion hysteresis in soft materials March 8th, 2024

Curcumin nanoemulsion is tested for treatment of intestinal inflammation: A formulation developed by Brazilian researchers proved effective in tests involving mice March 8th, 2024

Nanoscale CL thermometry with lanthanide-doped heavy-metal oxide in TEM March 8th, 2024

Water

Two-dimensional bimetallic selenium-containing metal-organic frameworks and their calcinated derivatives as electrocatalysts for overall water splitting March 8th, 2024

Computational system streamlines the design of fluidic devices: This computational tool can generate an optimal design for a complex fluidic device such as a combustion engine or a hydraulic pump December 9th, 2022

Taking salt out of the water equation October 7th, 2022

Scientists capture a ‘quantum tug’ between neighboring water molecules: Ultrafast electrons shed light on the web of hydrogen bonds that gives water its strange properties, vital for many chemical and biological processes July 8th, 2022

Industrial

Boron nitride nanotube fibers get real: Rice lab creates first heat-tolerant, stable fibers from wet-spinning process June 24th, 2022

Nanotubes: a promising solution for advanced rubber cables with 60% less conductive filler June 1st, 2022

Protective equipment with graphene nanotubes meets the strictest ESD safety standards March 25th, 2022

OCSiAl receives the green light for Luxembourg graphene nanotube facility project to power the next generation of electric vehicles in Europe March 4th, 2022

Nanobiotechnology

High-tech 'paint' could spare patients repeated surgeries March 8th, 2024

Researchers develop artificial building blocks of life March 8th, 2024

Curcumin nanoemulsion is tested for treatment of intestinal inflammation: A formulation developed by Brazilian researchers proved effective in tests involving mice March 8th, 2024

The Access to Advanced Health Institute receives up to $12.7 million to develop novel nanoalum adjuvant formulation for better protection against tuberculosis and pandemic influenza March 8th, 2024

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project