Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Determining the structures of nanocrystalline pharmaceuticals by electron diffraction

90° cut-off schematic of the camera as designed for the CM200 (Technische Universiteit Delft, The Netherlands).
CREDIT: van Genderen et al
90° cut-off schematic of the camera as designed for the CM200 (Technische Universiteit Delft, The Netherlands).

CREDIT: van Genderen et al

Abstract:
Reliable information about the structure of pharmaceutical compounds is important for patient safety, for the development of related drugs and for patenting purposes. However, working out the structures of pharmaceuticals can be tough. The individual molecules can pack together in the solid in different ways to form different polymorphs, and pertinent properties such as stability, bioavailability or how fast they dissolve in the stomach can vary from one polymorph to another. Single crystals (as used in standard X-ray diffraction experiments) therefore might not be representative of the bulk sample, or indeed might not even be available.

Determining the structures of nanocrystalline pharmaceuticals by electron diffraction

Chester, UK | Posted on February 29th, 2016

Moreover, the compounds themselves can be damaged by the high energy of the X-radiation used. As electrons are less damaging than X-rays by several orders of magnitude, using electron diffraction should be an attractive alternative, particularly when only nanometre-sized crystals are available. Cooling the sample to liquid-nitrogen temperatures ('cryo-cooling') can also help to minimize radiation damage, but the compound might change structure on cooling, so the structure that is obtained is not actually that of the material as taken by the patient at room temperature.

A group of scientists from a number of European countries have tackled all aspects of these problems by using low-dose electron diffraction, rotating the sample so that individual nanocrystals are not in the electron beam long enough to be damaged and collecting the diffraction data using a new type of detector developed by CERN [van Genderen et al. (2016), Acta Cryst. A72, doi:10.1107/S2053273315022500]. This new detector combines a high dynamic range with a very high signal-to-noise ratio and sensitivity to single electrons. Radiation damage was reduced so much that cooling the sample was not found to be necessary, allowing the team to study the anticonvulsant drug carbamazepine and nicotinic acid (vitamin B3) at room temperature. The data they collected were high enough quality that they could solve the structures of the two compounds using direct methods and software developed for X-ray crystallography.

Based on their experience with these case studies, the authors are planning to improve the design of their experimental setup further, and will also be developing programs specifically designed for handling electron-diffraction data.

####

For more information, please click here

Contacts:
Dr. Jonathan Agbenyega

44-124-434-2878

Copyright © International Union of Crystallography

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

RELATED JOURNAL ARTICLE:

Related News Press

News and information

Getting electrons to move in a semiconductor: Gallium oxide shows high electron mobility, making it promising for better and cheaper devices April 24th, 2018

JPK reports on research of the Mestroni Lab at the University of Colorado Denver which use the JPK NanoWizardŽ AFM to help in the characterization of cardiomyopathies April 24th, 2018

Organic solar cells reach record efficiency, benchmark for commercialization April 23rd, 2018

Remote-control shoots laser at nano-gold to turn on cancer-killing immune cells April 20th, 2018

Imaging

JPK reports on research of the Mestroni Lab at the University of Colorado Denver which use the JPK NanoWizardŽ AFM to help in the characterization of cardiomyopathies April 24th, 2018

Nanomedicine

JPK reports on research of the Mestroni Lab at the University of Colorado Denver which use the JPK NanoWizardŽ AFM to help in the characterization of cardiomyopathies April 24th, 2018

Remote-control shoots laser at nano-gold to turn on cancer-killing immune cells April 20th, 2018

Observing biological nanotransporters: Chemistry April 19th, 2018

Nanobiotix Shows NBTXR3 Nanoparticles Can Stoke Anti-Tumor Immune Response April 17th, 2018

Discoveries

Getting electrons to move in a semiconductor: Gallium oxide shows high electron mobility, making it promising for better and cheaper devices April 24th, 2018

JPK reports on research of the Mestroni Lab at the University of Colorado Denver which use the JPK NanoWizardŽ AFM to help in the characterization of cardiomyopathies April 24th, 2018

Organic solar cells reach record efficiency, benchmark for commercialization April 23rd, 2018

Remote-control shoots laser at nano-gold to turn on cancer-killing immune cells April 20th, 2018

Materials/Metamaterials

Getting electrons to move in a semiconductor: Gallium oxide shows high electron mobility, making it promising for better and cheaper devices April 24th, 2018

Organic solar cells reach record efficiency, benchmark for commercialization April 23rd, 2018

Salt boosts creation of 2-D materials: Rice University scientists show how salt lowers reaction temperatures to make novel materials April 18th, 2018

Individual impurity atoms detectable in graphene April 18th, 2018

Announcements

Getting electrons to move in a semiconductor: Gallium oxide shows high electron mobility, making it promising for better and cheaper devices April 24th, 2018

JPK reports on research of the Mestroni Lab at the University of Colorado Denver which use the JPK NanoWizardŽ AFM to help in the characterization of cardiomyopathies April 24th, 2018

Organic solar cells reach record efficiency, benchmark for commercialization April 23rd, 2018

Remote-control shoots laser at nano-gold to turn on cancer-killing immune cells April 20th, 2018

Interviews/Book Reviews/Essays/Reports/Podcasts/Journals/White papers

Getting electrons to move in a semiconductor: Gallium oxide shows high electron mobility, making it promising for better and cheaper devices April 24th, 2018

JPK reports on research of the Mestroni Lab at the University of Colorado Denver which use the JPK NanoWizardŽ AFM to help in the characterization of cardiomyopathies April 24th, 2018

Organic solar cells reach record efficiency, benchmark for commercialization April 23rd, 2018

Remote-control shoots laser at nano-gold to turn on cancer-killing immune cells April 20th, 2018

Tools

JPK reports on research of the Mestroni Lab at the University of Colorado Denver which use the JPK NanoWizardŽ AFM to help in the characterization of cardiomyopathies April 24th, 2018

Observing biological nanotransporters: Chemistry April 19th, 2018

Grand Opening of UC Irvine Materials Research Institute (IMRI) to Spotlight JEOL Center for Nanoscale Solutions: Renowned Materials Scientists to Present at the 1st International Symposium on Advanced Microscopy and Spectroscopy (ISAMS) April 18th, 2018

Individual impurity atoms detectable in graphene April 18th, 2018

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project