Nanotechnology Now

Our NanoNews Digest Sponsors
Heifer International

Wikipedia Affiliate Button

Home > Press > Researchers use nanotechnology to engineer ACL replacements: Researchers created a tri-component, synthetic graft for reconstructing torn anterior cruciate ligaments

Abstract:
Lindsey Vonn. Derrick Rose. Tom Brady. Mickey Mantle.

They have all fallen victim to the dreaded pop of the knee.

Connecting the femur to the tibia, the anterior cruciate ligament (ACL) rupture is one of the most devastating injuries in sports. No other injury has sidelined more athletes for a season or even the rest of a career. And ACL sprains and tears affect more people than just the pros. According to the American Association of Orthopaedic Surgeons, more than 250,000 ACL surgeries are performed annually in the United States, totaling up to more than $500 million in health care costs each year.

Researchers use nanotechnology to engineer ACL replacements: Researchers created a tri-component, synthetic graft for reconstructing torn anterior cruciate ligaments

Evanston, IL | Posted on December 30th, 2014

Not only is the ACL inelastic and prone to popping, it is incapable of healing itself, causing surgeons to rely on autografts for reconstruction. Most common is the bone-patellar tendon-bone (BPTB) graft, in which the surgeon removes part of the patellar tendon to replace the damaged ACL.

"BPTB autografts have a high incidence of knee pain and discomfort that does not go away," said Guillermo Ameer, professor of biomedical engineering at Northwestern University's McCormick School of Engineering and professor of surgery at the Feinberg School of Medicine. "By saving the patient's patellar tendon and using an off-the-shelf product, one may have a better chance of preserving the natural biomechanics of the knee."

Ameer and his research team are working to engineer such a product by combining three components: polyester fibers that are braided to increase strength and toughness, an inherently antioxidant and porous biomaterial previously created in Ameer's lab, and calcium nanocrystals, a mineral naturally found in human teeth and bones. His work is described in the paper "A biodegradable tri-component graft for anterior cruciate ligament reconstruction," which was published in the Nov. 21 issue of the Journal of Tissue Engineering and Regenerative Medicine. Eunji Chung, a postdoc at the University of Chicago and former graduate student in Ameer's lab, was the paper's first author.

During ACL reconstruction surgeries, tunnels are drilled into the femur and tibia bones to hold the new ligament in a fixed position. Ameer created a bone-like material by combining his antioxidant biomaterials with the calcium nanocrystals; he then embedded braided polyester fibers into it. The artificial ligament's bone-like ends healed to the native bone in the drilled tunnels, anchoring the ligament into place.

By studying an animal model, Ameer and his team noticed that the animal's natural bone and tissue cells migrated into the pores of the artificial ligament, populating it throughout and integrating with the bone tunnels. While longer-term studies are necessary to evaluate the potential use of the approach in humans, Ameer is optimistic about the results.

"The engineered ligament is biocompatible and can stabilize the knee, allowing the animal to function," Ameer said. "Most importantly, we may have found a way to integrate an artificial ligament with native bone."

####

For more information, please click here

Contacts:
Megan Fellman

847-491-3115

Copyright © Northwestern University

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Drilling speed increased by 20% yet another upgrade in the oil & gas sector made possible by graphene nanotubes January 15th, 2019

Chirality in 'real-time' January 14th, 2019

New materials could help improve the performance of perovskite solar cells January 11th, 2019

Media invited to open meeting on the future of quantum technology held at RIT Jan. 23-25: Leaders from NASA, NSF, NIST and Sandia National Laboratory to attend January 11th, 2019

Nanomedicine

Chirality in 'real-time' January 14th, 2019

Ultra-sensitive sensor with gold nanoparticle array January 9th, 2019

Arrowhead Pharmaceuticals Begins Dosing in Phase 1 Study of ARO-ANG3 for Treatment of Dyslipidemias and Metabolic Diseases January 7th, 2019

Arrowhead Pharmaceuticals Files for Regulatory Clearance to Begin Phase 1 Study of ARO-APOC3 for Treatment of Hypertriglyceridemia January 7th, 2019

Discoveries

Chirality in 'real-time' January 14th, 2019

New materials could help improve the performance of perovskite solar cells January 11th, 2019

Spintronics 'miracle material' put to the test: Physicists build devices using mineral perovskite January 11th, 2019

Cartilage could be key to safe 'structural batteries' January 11th, 2019

Announcements

Drilling speed increased by 20% yet another upgrade in the oil & gas sector made possible by graphene nanotubes January 15th, 2019

Chirality in 'real-time' January 14th, 2019

Spintronics 'miracle material' put to the test: Physicists build devices using mineral perovskite January 11th, 2019

Cartilage could be key to safe 'structural batteries' January 11th, 2019

Interviews/Book Reviews/Essays/Reports/Podcasts/Journals/White papers

2D materials may enable electric vehicles to get 500 miles on a single charge January 11th, 2019

New materials could help improve the performance of perovskite solar cells January 11th, 2019

Spintronics 'miracle material' put to the test: Physicists build devices using mineral perovskite January 11th, 2019

Cartilage could be key to safe 'structural batteries' January 11th, 2019

Sports

Collagen nanofibrils in mammalian tissues get stronger with exercise December 14th, 2018

Epoxy compound gets a graphene bump: Rice scientists combine graphene foam, epoxy into tough, conductive composite November 14th, 2018

UVA multidisciplinary engineering team designs technology for smart materials: The invention could lead to devices and manufactured goods, such as fabrics, that can dynamically regulate between thermally insulating and cooling August 17th, 2018

Graphene-based desiccant offers super dry solution to moisture control June 1st, 2018

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project