Home > Press > Polymeric Drug Carrier Produced in Iran for Target Delivery System
Abstract:
In this research, biodegradable polymers have been used in the production of nanocarrier, which enable the release of drug by controlling changes in temperature. The production and characterization of the nanocarrier is at the laboratorial stage at the moment.
Polymeric Drug Carrier Produced in Iran for Target Delivery System
Tehran, Iran | Posted on December 9th, 2014Modified hydrophobic polysaccharides have recently attracted the attention of many researchers. These materials are important due to their biocompatibility, biodegradability, temperature responsiveness, ability to form nanoparticles and encapsulation of hydrophobic drugs. In this project, the researchers tried to produce and characterize a target delivery system by using anticancer nanocarrier made of these materials.
According to Dr. Ma'soumeh Baqeri, one of the researchers, hydroxypropyl cellulose (HPC) was chosen in this research as a natural, biocompatible and biodegradable polymer, and the new bi-polymer was produced based on it. To this end, the connection of cholesterol and polyethylene glycol to HPC was used. After the final modification by connection of biotin to the nanocarrier, it was used to carry paclitaxel anticancer drug to cancerous cells in a target delivery manner.
Toxicity study of the produced missiles showed that the carrier is not toxic for natural cells. Results obtained from cellular sorption showed that the presence of biotin decreases the amount of living cancerous cells due to the increase in taking of drug carrier by cancerous cells.
Results of the research have been published in Journal of Polymer Research, vol. 21, issue 567, 2014, pp. 1-15.
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