Nanotechnology Now

Our NanoNews Digest Sponsors



Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > Like cling wrap, new biomaterial can coat tricky burn wounds and block out infection

Super-thin nanosheets could help transform the treatment of burn wounds.

Credit: Yosuke Okamura
Super-thin nanosheets could help transform the treatment of burn wounds.

Credit: Yosuke Okamura

Abstract:
Title

Development of fragmented nanosheets and patchwork coating as aqueous surface modifiers for biomedical applications

Abstract

Free-standing ultra-thin films (often called nanosheets) composed of biocompatible polymers (size >cm, thickness <100 nm) represent unique properties as good adhesiveness, exquisite flexibility, and a high degree of transparency1). However, they are often hard to coat irregular/uneven interfaces due to the structural aspect (cm-size). In this paper, we propose a novel nanobiomaterial "fragmented nanosheets" to effectively coat the uneven interfaces and a patchwork coating as an aqueous surface modifier for biomedical applications. Free-standing nanosheets composed of biodegradable poly(L-lactic acid) (PLLA) with a thickness of 60 6 nm were successfully mass-produced by a simple combination of a spin-coating-assisted multi-layering process of poly(vinyl alcohol) and PLLA and a peeling technique. Intriguingly, the PLLA nanosheets could be easily fragmented by homogenization at 30,000 rpm and then reconstructed into a sheet on various interfaces (steels, glasses, plastics and skin) without any adhesive reagents. The adhesion behavior resembled a "patchwork", which was evident as a sequential series of structural colors on the substrate. For a biomedical application, we demonstrated that the patchwork coating of fragmented nanosheets acts as an excellent barrier against burn wound infections by Pseudomonas aeruginosa2). This material thus constitutes a promising alternative to conventional therapy for burn patients. We will also propose that the patchwork coating of other biocompatible polymers (polyimide and polyurethane etc.) containing phospholipid moiety3) converts various substrates to blood-compatible surfaces.

1) Okamura, Y. et al. Adv. Mater. 21, 4388-92 (2009).

2) Okamura, Y. et al. Adv. Mater. 25, 545-51 (2013).

3) Nagase Y. et al. Biomedical Engineering - Frontiers and Challenges, Chapter 11, 217-232, InTech, Croatia (2011).

Like cling wrap, new biomaterial can coat tricky burn wounds and block out infection

San Francisco, CA | Posted on August 10th, 2014


Wrapping wound dressings around fingers and toes can be tricky, but for burn victims, guarding them against infection is critical. Today, scientists are reporting the development of novel, ultrathin coatings called nanosheets that can cling to the body's most difficult-to-protect contours and keep bacteria at bay.

The researchers are speaking about their materials, which they've tested on mice, at the 248th National Meeting & Exposition of the American Chemical Society (ACS), the world's largest scientific society.

The meeting features nearly 12,000 presentations on a wide range of science topics and is being held here through Thursday.

Yosuke Okamura, Ph.D., explains that existing wound dressings work well when it comes to treating burns on relatively flat and broad areas. But the human body has curves, wrinkles and ridges that present problems for these dressings. So Okamura's team developed a novel biomaterial out of tiny pieces of nanosheets that are super-flexible and sticky.

"The nanosheets can adhere not only to flat surfaces, but also to uneven and irregular surfaces without adding any adhesives," he says.

That would make a big difference in the way burn victims are treated. According to the Centers for Disease Control and Prevention, someone is injured by fire every 30 minutes. Burn wounds are vulnerable to infection, and keeping them sealed off from bacteria is essential for a successful recovery.

Okamura's team at Tokai University makes the nanosheets out of a biodegradable polyester called poly(L-lactic acid), or PLLA. They put the material into a test tube with water and spin it, which breaks up the sheets into even smaller pieces. When they pour the liquid onto a flat surface, the tiny fragments overlap in a patchwork and dry as a single nanosheet.

They tested out the nanosheets' ability to coat small and irregular shapes by dipping different things into the mixture, including a metal needle and a mouse's fingers. The nanosheet patchwork effectively covered even the smallest bumps and wrinkles on the mouse's digits, and after the material dried, it clung in place.

When the researchers tested the nanosheets on burns, the dressing effectively kept out the common bacteria, Pseudomonas aeruginosa. This species of pathogen is often a culprit in skin infections and is notorious for causing hospital-acquired infections that can be deadly. Multi-drug resistant strains are also a serious concern.

The dressing protected wounds from infection for three continuous days. With an additional coating, the nanosheets kept bacteria out for a total of six days. That means the material, if eventually approved for human patients, could cut down the number of times dressings have to be changed. With an eye toward human clinical trials, the researchers are currently planning large-scale animal tests and safety tests.

In addition to PLLA nanosheets, Okamura's group has recently started developing a novel set of similar, super-flexible, patchwork coatings composed of polymers with a phosphorylcholine group. They have shown that these materials are compatible with blood and could act as coatings for medical devices, such as catheters.

###

Okamura acknowledges funding from the Japan Society for the Promotion of Science.

####

About American Chemical Society
The American Chemical Society is a nonprofit organization chartered by the U.S. Congress. With more than 161,000 members, ACS is the world's largest scientific society and a global leader in providing access to chemistry-related research through its multiple databases, peer-reviewed journals and scientific conferences. Its main offices are in Washington, D.C., and Columbus, Ohio.

For more information, please click here

Contacts:
Michael Bernstein
415-978-3506 (S.F. Press Center, Aug. 9-13)
202-872-6042


Katie Cottingham, Ph.D.
415-978-3506 (S.F. Press Center, Aug. 9-13)
301-775-8455

Copyright © American Chemical Society

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Piezoelectricity in a 2-D semiconductor: Berkeley Lab researchers discovery of piezoelectricty in molybdenum disulfide holds promise for future MEMS December 22nd, 2014

Quantum physics just got less complicated December 22nd, 2014

Enzyme Biosensor Used for Rapid Measurement of Drug December 22nd, 2014

Universality of charge order in cuprate superconductors: Charge order has been established in another class of cuprate superconductors, highlighting the importance of the phenomenon as a general property of these high-Tc materials December 22nd, 2014

Govt.-Legislation/Regulation/Funding/Policy

Piezoelectricity in a 2-D semiconductor: Berkeley Lab researchers discovery of piezoelectricty in molybdenum disulfide holds promise for future MEMS December 22nd, 2014

Atom-thick CCD could capture images: Rice University scientists develop two-dimensional, light-sensitive material December 20th, 2014

Oregon researchers glimpse pathway of sunlight to electricity: Collaboration with Lund University uses modified UO spectroscopy equipment to study 'maze' of connections in photoactive quantum dots December 19th, 2014

ORNL microscopy pencils patterns in polymers at the nanoscale December 17th, 2014

Nanomedicine

Enzyme Biosensor Used for Rapid Measurement of Drug December 22nd, 2014

Creation of 'Rocker' protein opens way for new smart molecules in medicine, other fields December 18th, 2014

Iranian Researchers Produce Electrical Pieces Usable in Human Body December 18th, 2014

Zenosense, Inc. - Hospital Collaboration - 400 Person Lung Cancer Detection Trial December 17th, 2014

Discoveries

Piezoelectricity in a 2-D semiconductor: Berkeley Lab researchers discovery of piezoelectricty in molybdenum disulfide holds promise for future MEMS December 22nd, 2014

Quantum physics just got less complicated December 22nd, 2014

Enzyme Biosensor Used for Rapid Measurement of Drug December 22nd, 2014

Universality of charge order in cuprate superconductors: Charge order has been established in another class of cuprate superconductors, highlighting the importance of the phenomenon as a general property of these high-Tc materials December 22nd, 2014

Announcements

Piezoelectricity in a 2-D semiconductor: Berkeley Lab researchers discovery of piezoelectricty in molybdenum disulfide holds promise for future MEMS December 22nd, 2014

Quantum physics just got less complicated December 22nd, 2014

Enzyme Biosensor Used for Rapid Measurement of Drug December 22nd, 2014

Universality of charge order in cuprate superconductors: Charge order has been established in another class of cuprate superconductors, highlighting the importance of the phenomenon as a general property of these high-Tc materials December 22nd, 2014

Interviews/Book Reviews/Essays/Reports/Podcasts/Journals/White papers

Piezoelectricity in a 2-D semiconductor: Berkeley Lab researchers discovery of piezoelectricty in molybdenum disulfide holds promise for future MEMS December 22nd, 2014

Quantum physics just got less complicated December 22nd, 2014

Enzyme Biosensor Used for Rapid Measurement of Drug December 22nd, 2014

Universality of charge order in cuprate superconductors: Charge order has been established in another class of cuprate superconductors, highlighting the importance of the phenomenon as a general property of these high-Tc materials December 22nd, 2014

Alliances/Partnerships/Distributorships

SUNY Poly NanoCollege Faculty Member Selected as American Physical Society Fellow: SUNY Poly Associate Professor of Nanoscience Dr. Vincent LaBella Recognized for Significant Technological Innovations that Enable Interactive Learning December 17th, 2014

New 'electronic skin' for prosthetics, robotics detects pressure from different directions December 10th, 2014

SEMATECH Reports Significant Progress in EUV Resist Outgas Testing: Technologists from SEMATECH and JSR demonstrate outgas test results that further enable EUV lithography for high-volume manufacturing readiness December 3rd, 2014

Toward a low-cost 'artificial leaf' that produces clean hydrogen fuel December 3rd, 2014

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More










ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE