Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Like cling wrap, new biomaterial can coat tricky burn wounds and block out infection

Super-thin nanosheets could help transform the treatment of burn wounds.

Credit: Yosuke Okamura
Super-thin nanosheets could help transform the treatment of burn wounds.

Credit: Yosuke Okamura

Abstract:
Title

Development of fragmented nanosheets and patchwork coating as aqueous surface modifiers for biomedical applications

Abstract

Free-standing ultra-thin films (often called nanosheets) composed of biocompatible polymers (size >cm, thickness <100 nm) represent unique properties as good adhesiveness, exquisite flexibility, and a high degree of transparency1). However, they are often hard to coat irregular/uneven interfaces due to the structural aspect (cm-size). In this paper, we propose a novel nanobiomaterial "fragmented nanosheets" to effectively coat the uneven interfaces and a patchwork coating as an aqueous surface modifier for biomedical applications. Free-standing nanosheets composed of biodegradable poly(L-lactic acid) (PLLA) with a thickness of 60 Ī 6 nm were successfully mass-produced by a simple combination of a spin-coating-assisted multi-layering process of poly(vinyl alcohol) and PLLA and a peeling technique. Intriguingly, the PLLA nanosheets could be easily fragmented by homogenization at 30,000 rpm and then reconstructed into a sheet on various interfaces (steels, glasses, plastics and skin) without any adhesive reagents. The adhesion behavior resembled a "patchwork", which was evident as a sequential series of structural colors on the substrate. For a biomedical application, we demonstrated that the patchwork coating of fragmented nanosheets acts as an excellent barrier against burn wound infections by Pseudomonas aeruginosa2). This material thus constitutes a promising alternative to conventional therapy for burn patients. We will also propose that the patchwork coating of other biocompatible polymers (polyimide and polyurethane etc.) containing phospholipid moiety3) converts various substrates to blood-compatible surfaces.

1) Okamura, Y. et al. Adv. Mater. 21, 4388-92 (2009).

2) Okamura, Y. et al. Adv. Mater. 25, 545-51 (2013).

3) Nagase Y. et al. Biomedical Engineering - Frontiers and Challenges, Chapter 11, 217-232, InTech, Croatia (2011).

Like cling wrap, new biomaterial can coat tricky burn wounds and block out infection

San Francisco, CA | Posted on August 10th, 2014


Wrapping wound dressings around fingers and toes can be tricky, but for burn victims, guarding them against infection is critical. Today, scientists are reporting the development of novel, ultrathin coatings called nanosheets that can cling to the body's most difficult-to-protect contours and keep bacteria at bay.

The researchers are speaking about their materials, which they've tested on mice, at the 248th National Meeting & Exposition of the American Chemical Society (ACS), the world's largest scientific society.

The meeting features nearly 12,000 presentations on a wide range of science topics and is being held here through Thursday.

Yosuke Okamura, Ph.D., explains that existing wound dressings work well when it comes to treating burns on relatively flat and broad areas. But the human body has curves, wrinkles and ridges that present problems for these dressings. So Okamura's team developed a novel biomaterial out of tiny pieces of nanosheets that are super-flexible and sticky.

"The nanosheets can adhere not only to flat surfaces, but also to uneven and irregular surfaces without adding any adhesives," he says.

That would make a big difference in the way burn victims are treated. According to the Centers for Disease Control and Prevention, someone is injured by fire every 30 minutes. Burn wounds are vulnerable to infection, and keeping them sealed off from bacteria is essential for a successful recovery.

Okamura's team at Tokai University makes the nanosheets out of a biodegradable polyester called poly(L-lactic acid), or PLLA. They put the material into a test tube with water and spin it, which breaks up the sheets into even smaller pieces. When they pour the liquid onto a flat surface, the tiny fragments overlap in a patchwork and dry as a single nanosheet.

They tested out the nanosheets' ability to coat small and irregular shapes by dipping different things into the mixture, including a metal needle and a mouse's fingers. The nanosheet patchwork effectively covered even the smallest bumps and wrinkles on the mouse's digits, and after the material dried, it clung in place.

When the researchers tested the nanosheets on burns, the dressing effectively kept out the common bacteria, Pseudomonas aeruginosa. This species of pathogen is often a culprit in skin infections and is notorious for causing hospital-acquired infections that can be deadly. Multi-drug resistant strains are also a serious concern.

The dressing protected wounds from infection for three continuous days. With an additional coating, the nanosheets kept bacteria out for a total of six days. That means the material, if eventually approved for human patients, could cut down the number of times dressings have to be changed. With an eye toward human clinical trials, the researchers are currently planning large-scale animal tests and safety tests.

In addition to PLLA nanosheets, Okamura's group has recently started developing a novel set of similar, super-flexible, patchwork coatings composed of polymers with a phosphorylcholine group. They have shown that these materials are compatible with blood and could act as coatings for medical devices, such as catheters.

###

Okamura acknowledges funding from the Japan Society for the Promotion of Science.

####

About American Chemical Society
The American Chemical Society is a nonprofit organization chartered by the U.S. Congress. With more than 161,000 members, ACS is the world's largest scientific society and a global leader in providing access to chemistry-related research through its multiple databases, peer-reviewed journals and scientific conferences. Its main offices are in Washington, D.C., and Columbus, Ohio.

For more information, please click here

Contacts:
Michael Bernstein
415-978-3506 (S.F. Press Center, Aug. 9-13)
202-872-6042


Katie Cottingham, Ph.D.
415-978-3506 (S.F. Press Center, Aug. 9-13)
301-775-8455

Copyright © American Chemical Society

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Report highlights opportunities and risks associated with synthetic biology and bioengineering November 22nd, 2017

Quantum optics allows us to abandon expensive lasers in spectroscopy: Lomonosov Moscow State University scientists have invented a new method of spectroscopy November 21st, 2017

Nano-watch has steady hands November 21st, 2017

Nano Global, Arm Collaborate on Artificial Intelligence Chip to Drive Health Revolution by Capturing and Analyzing Molecular Data in Real Time November 21st, 2017

Govt.-Legislation/Regulation/Funding/Policy

EC Project Aims at Creating and Commercializing Cyber-Physical-System Solutions November 14th, 2017

Nanobiotix presented new clinical and pre-clinical data confirming NBTXR3ís significant potential role in Immuno-Oncology at SITC Annual Meeting November 14th, 2017

Leti Joins DARPA-Funded Project to Develop Implantable Device for Restoring Vision November 9th, 2017

Nanoshells could deliver more chemo with fewer side effects: In vitro study verifies method for remotely triggering release of cancer drugs November 8th, 2017

Nanomedicine

Nanoparticles could allow for faster, better medicine: Exposure of nanoparticles in the body allows for more effective delivery November 20th, 2017

Nanobiotix presented new clinical and pre-clinical data confirming NBTXR3ís significant potential role in Immuno-Oncology at SITC Annual Meeting November 14th, 2017

Arrowhead to Present at 29th Annual Piper Jaffray Healthcare Conference November 14th, 2017

A new way to mix oil and water: Condensation-based method developed at MIT could create stable nanoscale emulsions November 8th, 2017

Discoveries

Quantum optics allows us to abandon expensive lasers in spectroscopy: Lomonosov Moscow State University scientists have invented a new method of spectroscopy November 21st, 2017

Nano-watch has steady hands November 21st, 2017

Nanoparticles could allow for faster, better medicine: Exposure of nanoparticles in the body allows for more effective delivery November 20th, 2017

ICN2 researchers compute unprecedented values for spin lifetime anisotropy in graphene November 17th, 2017

Announcements

Report highlights opportunities and risks associated with synthetic biology and bioengineering November 22nd, 2017

Quantum optics allows us to abandon expensive lasers in spectroscopy: Lomonosov Moscow State University scientists have invented a new method of spectroscopy November 21st, 2017

Nano-watch has steady hands November 21st, 2017

Nano Global, Arm Collaborate on Artificial Intelligence Chip to Drive Health Revolution by Capturing and Analyzing Molecular Data in Real Time November 21st, 2017

Interviews/Book Reviews/Essays/Reports/Podcasts/Journals/White papers

Report highlights opportunities and risks associated with synthetic biology and bioengineering November 22nd, 2017

Quantum optics allows us to abandon expensive lasers in spectroscopy: Lomonosov Moscow State University scientists have invented a new method of spectroscopy November 21st, 2017

Nano-watch has steady hands November 21st, 2017

Nanoparticles could allow for faster, better medicine: Exposure of nanoparticles in the body allows for more effective delivery November 20th, 2017

Alliances/Trade associations/Partnerships/Distributorships

Nano Global, Arm Collaborate on Artificial Intelligence Chip to Drive Health Revolution by Capturing and Analyzing Molecular Data in Real Time November 21st, 2017

EC Project Aims at Creating and Commercializing Cyber-Physical-System Solutions November 14th, 2017

GLOBALFOUNDRIES, Fudan Team to Deliver Next Generation Dual Interface Smart Card November 14th, 2017

Leti Coordinating Project to Develop Innovative Drivetrains for 3rd-generation Electric Vehicles: CEA Techís Contribution Includes Litenís Knowhow in Magnetic Materials and Simulation And Letiís Expertise in Wide-bandgap Semiconductors October 20th, 2017

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project