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Iranian chemists from Bu-Ali Sina (Avicenna) University designed a nanosensor with very high sensing ability to measure the amount of anti-HIV drugs.
The production method proposed for this sensor is simple and cost-effective and the results of the research can be used in medical industries and pharmaceutics.
Zidovudine drug is known as the first anti-HIV drug in the world. However and according to studies, concentrations higher than 10 micromolar of this drug in blood causes undesired side effects in human body. Therefore, sensitive and accurate sensors are required to detect effective amounts of the drug and track the changes in its concentration in patient's blood. By using a combination of carbon nanotubes and silver nanofilm, researchers produced an electrical sensor to achieve this goal.
The designed sensor is able to measure very low concentrations of Zidovudine anti-HIV drug (about 0.15 micromolar). The sensor is also successful in the effective measurement of this drug in blood plasma sample, and it succeeded in the measurement of 98% of the actual amount of the drug.
In this research, silver has been coated on carbon nanotube bed in form of a nanoscaled layer to increase the active area of the electrode. To this end, the electrode surface was firstly coated with carbon nanotubes with high specific area and high electrical conduction. Then, a coating of silver was placed on the nanostructured bed in form of nanofilm. The proposed method can be an appropriate approach to obtain the maximum possible active area in sensors.
Results of the research have been published in Materials Science and Engineering: C, vol. 39, issue 1, February 2014, pp. 105-112.
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