Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Iranian Researchers Make Smart Nanocarriers to Reduce Side Effects of Anticancer Drugs

Abstract:
Iranian researchers from Tarbiat Modarres University succeeded in the production of a smart nanocarrier that can be used in medical industries, pharmaceutics, and specially in cancer treatment.

Iranian Researchers Make Smart Nanocarriers to Reduce Side Effects of Anticancer Drugs

Tehran, Iran | Posted on June 11th, 2014

The nanocarrier has polymeric structure and reduces the amount of the consumed drug as well as its side effects.

Methotrexate (MTX) is one of the most common and effective anticancer drugs in chemotherapy, which is widely used in the treatment of various types of aggressive tumors such as leukemia, lung cancer, ovarian cancer, colon cancer, and other cancers. Conductive polymers are among the most important intelligent materials that in addition to compatibility, they provide the possibility of controlled release of the drugs by using an external electrochemical agent. However, there are some problems in the loading of anticancer drugs in these polymers such as low efficiency or the low stability of the polymer.

In this research, methotrexate has been loaded in the structure of nanostructured polypyrrole as the conductive intelligent polymer through a simple method, and the parameters effective on the release of the drug were studied. Electrical polymerization of polypyrrole in the presence of MTX solely results in a very low quality and instable polymer with very low amount of loaded drug. However, the problem is solved in the presence of cationic surfactant of cetylpyridinium (CP), and the amount of loaded drug increases significantly. On the other hand, the size and structure of the nanocarrier can be controlled by adjusting the temperature and pH value of the media, and the time and amount of the imposed potential.

The results showed that the correlation of the performance kinetics of the nanocarrier is in good agreement with Avrami Equation, and the amount of drug release can be controlled by changing the temperature and potential.

Results of the research have been published in Electrochimica Acta, vol. 130, issue 1, April 2014, pp. 488-496.

####

For more information, please click here

Copyright © Fars News Agency

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

News from Quorum: Experienced electron microscopist, David McCarthy, talks about working with Quorum and his use of their coaters and cryo-SEM preparation instrumentation January 24th, 2017

Tough aqua material for water purification: Decontamination of water with a robust and sustainable membrane assembled from 2 synergistically working components January 24th, 2017

Harris & Harris Group Announces the Filing of Preliminary Proxy Materials Detailing Its Proposed Conversion From a BDC to a Registered Closed-End Fund January 24th, 2017

The speed limit for intra-chip communications in microprocessors of the future January 23rd, 2017

Nanomedicine

New, old science combine to make faster medical test: Nanoparticles and Faraday rotation allow faster diagnoses January 23rd, 2017

New research helps to meet the challenges of nanotechnology: Research helps to make the most of nanoscale catalytic effects for nanotechnology January 20th, 2017

Chemists Cook up New Nanomaterial and Imaging Method: Nanomaterials can store all kinds of things, including energy, drugs and other cargo January 19th, 2017

'5-D protein fingerprinting' could give insights into Alzheimer's, Parkinson's January 19th, 2017

Discoveries

Tough aqua material for water purification: Decontamination of water with a robust and sustainable membrane assembled from 2 synergistically working components January 24th, 2017

The speed limit for intra-chip communications in microprocessors of the future January 23rd, 2017

New, old science combine to make faster medical test: Nanoparticles and Faraday rotation allow faster diagnoses January 23rd, 2017

Traffic jam in empty space: New success for Konstanz physicists in studying the quantum vacuum January 22nd, 2017

Announcements

News from Quorum: Experienced electron microscopist, David McCarthy, talks about working with Quorum and his use of their coaters and cryo-SEM preparation instrumentation January 24th, 2017

Tough aqua material for water purification: Decontamination of water with a robust and sustainable membrane assembled from 2 synergistically working components January 24th, 2017

Harris & Harris Group Announces the Filing of Preliminary Proxy Materials Detailing Its Proposed Conversion From a BDC to a Registered Closed-End Fund January 24th, 2017

The speed limit for intra-chip communications in microprocessors of the future January 23rd, 2017

Interviews/Book Reviews/Essays/Reports/Podcasts/Journals/White papers

Tough aqua material for water purification: Decontamination of water with a robust and sustainable membrane assembled from 2 synergistically working components January 24th, 2017

The speed limit for intra-chip communications in microprocessors of the future January 23rd, 2017

New, old science combine to make faster medical test: Nanoparticles and Faraday rotation allow faster diagnoses January 23rd, 2017

Traffic jam in empty space: New success for Konstanz physicists in studying the quantum vacuum January 22nd, 2017

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project