Nanotechnology Now

Our NanoNews Digest Sponsors



Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > EPFL Scientists use nanoscale IR spectroscopy to demonstrate α to β secondary structure transition associated with amyloid formation

The Anasys nanoIR system installed in the lab of Prof. Kulik from Prof. Dietler’s group at EPFL.
The Anasys nanoIR system installed in the lab of Prof. Kulik from Prof. Dietler’s group at EPFL.

Abstract:
Anasys Instruments reports on EPFL's latest research on lysozyme droplets and α-synuclein macromolecular aggregates illustrating application of the nanoscale AFM-IR technique to demonstrate α to β secondary structure transition associated with amyloid formation.

EPFL Scientists use nanoscale IR spectroscopy to demonstrate α to β secondary structure transition associated with amyloid formation

Santa Barbara, CA | Posted on June 10th, 2014

Proteins aggregating into amyloid structures are involved in important neurodegenerative disorders such as Alzheimer's and Parkinson's disease. During aggregation, initially monomeric proteins undergo internal structural rearrangement forming amyloid fibrils with a universal cross β -sheet quaternary structure. . During fibrillation, several coexisting amyloidogenic species are formed and the study of these species would allow improved understanding of the pathways of amyloid formation.

Conventional FTIR spectroscopy is a key method for studying the structural conversion during amyloid formation but it is only able to give average spectra of a heterogeneous solution due to its poor spatial resolution. Sub-micron chemical characterization, enabled by the AFM-IR technique, of amyloidogenic structures such as oligomers and fibrils is central to understanding how proteins misfold and aggregate. The researchers clearly resolved the shift in the amide I band which identifies an α to β secondary structure transition associated with amyloid formation and were able to spatially map the transition. This work was published in the journal Lab on a Chip [1].

The analytical system used for this research is the nanoIR product manufactured by Anasys Instruments. Andrzej Kulik, the main researcher behind this effort at EPFL, has described AFM-IR as "one of the most important breakthroughs in the AFM technique since it adds chemical composition information to nanoscale morphology. Its ease of use will ensure its wide adoption given the crucial importance of nanoscale chemical composition in most research applications."

####

About Anasys Instruments
Anasys Instruments designs breakthrough, award-winning products that provide nanoscale probe based analytical techniques while providing high quality AFM imaging. We pioneered nanoscale IR spectroscopy, nanoscale thermal analysis and wideband nanoscale dynamic mechanical spectroscopy.

For more information, please click here

Contacts:
Anasys contact:
Roshan Shetty
Anasys Instruments Corporation
121 Gray Avenue, Suite 100
Santa Barbara
CA 93101 USA
Tel: +1 (805) 730-3310
www.anasysinstruments.com


Media contact:
Jezz Leckenby
Talking Science Limited
39 de Bohun Court
Saffron Walden
Essex CB10 2BA, UK
Tel +44 (0) 1799 521881
Mob +44 (0) 7843 012997
www.talking-science.com

Copyright © Anasys Instruments

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

Reference

Related News Press

News and information

Scientists reveal breakthrough in optical fiber communications December 21st, 2014

Atom-thick CCD could capture images: Rice University scientists develop two-dimensional, light-sensitive material December 20th, 2014

Oregon researchers glimpse pathway of sunlight to electricity: Collaboration with Lund University uses modified UO spectroscopy equipment to study 'maze' of connections in photoactive quantum dots December 19th, 2014

Instant-start computers possible with new breakthrough December 19th, 2014

Lab-on-a-chip

“Line dancing bacteria win the 2014 Dolomite and Lab on a Chip Video Competition” December 16th, 2014

Dolomite and Lab on a Chip launch Productizing Science® Competition 2015 October 7th, 2014

New chip promising for tumor-targeting research September 22nd, 2014

The Pocket Project will develop a low-cost and accurate point-of-care test to diagnose Tuberculosis: ICN2 holds a follow-up meeting of the Project on September 18th - 19th September 18th, 2014

Discoveries

Scientists reveal breakthrough in optical fiber communications December 21st, 2014

Atom-thick CCD could capture images: Rice University scientists develop two-dimensional, light-sensitive material December 20th, 2014

Oregon researchers glimpse pathway of sunlight to electricity: Collaboration with Lund University uses modified UO spectroscopy equipment to study 'maze' of connections in photoactive quantum dots December 19th, 2014

Instant-start computers possible with new breakthrough December 19th, 2014

Announcements

Scientists reveal breakthrough in optical fiber communications December 21st, 2014

Atom-thick CCD could capture images: Rice University scientists develop two-dimensional, light-sensitive material December 20th, 2014

Oregon researchers glimpse pathway of sunlight to electricity: Collaboration with Lund University uses modified UO spectroscopy equipment to study 'maze' of connections in photoactive quantum dots December 19th, 2014

Instant-start computers possible with new breakthrough December 19th, 2014

Interviews/Book Reviews/Essays/Reports/Podcasts/Journals/White papers

Scientists reveal breakthrough in optical fiber communications December 21st, 2014

Atom-thick CCD could capture images: Rice University scientists develop two-dimensional, light-sensitive material December 20th, 2014

Oregon researchers glimpse pathway of sunlight to electricity: Collaboration with Lund University uses modified UO spectroscopy equipment to study 'maze' of connections in photoactive quantum dots December 19th, 2014

Instant-start computers possible with new breakthrough December 19th, 2014

Tools

Atom-thick CCD could capture images: Rice University scientists develop two-dimensional, light-sensitive material December 20th, 2014

Oregon researchers glimpse pathway of sunlight to electricity: Collaboration with Lund University uses modified UO spectroscopy equipment to study 'maze' of connections in photoactive quantum dots December 19th, 2014

Switching to spintronics: Berkeley Lab reports on electric field switching of ferromagnetism at room temp December 17th, 2014

ORNL microscopy pencils patterns in polymers at the nanoscale December 17th, 2014

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More










ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE