Nanotechnology Now

Our NanoNews Digest Sponsors


Heifer International

Wikipedia Affiliate Button

Home > Press > EPFL Scientists use nanoscale IR spectroscopy to demonstrate α to β secondary structure transition associated with amyloid formation

The Anasys nanoIR system installed in the lab of Prof. Kulik from Prof. Dietlerís group at EPFL.
The Anasys nanoIR system installed in the lab of Prof. Kulik from Prof. Dietlerís group at EPFL.

Abstract:
Anasys Instruments reports on EPFL's latest research on lysozyme droplets and α-synuclein macromolecular aggregates illustrating application of the nanoscale AFM-IR technique to demonstrate α to β secondary structure transition associated with amyloid formation.

EPFL Scientists use nanoscale IR spectroscopy to demonstrate α to β secondary structure transition associated with amyloid formation

Santa Barbara, CA | Posted on June 10th, 2014

Proteins aggregating into amyloid structures are involved in important neurodegenerative disorders such as Alzheimer's and Parkinson's disease. During aggregation, initially monomeric proteins undergo internal structural rearrangement forming amyloid fibrils with a universal cross β -sheet quaternary structure. . During fibrillation, several coexisting amyloidogenic species are formed and the study of these species would allow improved understanding of the pathways of amyloid formation.

Conventional FTIR spectroscopy is a key method for studying the structural conversion during amyloid formation but it is only able to give average spectra of a heterogeneous solution due to its poor spatial resolution. Sub-micron chemical characterization, enabled by the AFM-IR technique, of amyloidogenic structures such as oligomers and fibrils is central to understanding how proteins misfold and aggregate. The researchers clearly resolved the shift in the amide I band which identifies an α to β secondary structure transition associated with amyloid formation and were able to spatially map the transition. This work was published in the journal Lab on a Chip [1].

The analytical system used for this research is the nanoIR product manufactured by Anasys Instruments. Andrzej Kulik, the main researcher behind this effort at EPFL, has described AFM-IR as "one of the most important breakthroughs in the AFM technique since it adds chemical composition information to nanoscale morphology. Its ease of use will ensure its wide adoption given the crucial importance of nanoscale chemical composition in most research applications."

####

About Anasys Instruments
Anasys Instruments designs breakthrough, award-winning products that provide nanoscale probe based analytical techniques while providing high quality AFM imaging. We pioneered nanoscale IR spectroscopy, nanoscale thermal analysis and wideband nanoscale dynamic mechanical spectroscopy.

For more information, please click here

Contacts:
Anasys contact:
Roshan Shetty
Anasys Instruments Corporation
121 Gray Avenue, Suite 100
Santa Barbara
CA 93101 USA
Tel: +1 (805) 730-3310
www.anasysinstruments.com


Media contact:
Jezz Leckenby
Talking Science Limited
39 de Bohun Court
Saffron Walden
Essex CB10 2BA, UK
Tel +44 (0) 1799 521881
Mob +44 (0) 7843 012997
www.talking-science.com

Copyright © Anasys Instruments

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

Reference

Related News Press

News and information

Nanoparticle versus cancer: Scientists have created nanoparticles which cure cancer harmlessly July 22nd, 2016

Quantum drag:University of Iowa physicist says current in one iron magnetic sheet can create quantized spin waves in another, separate sheet July 22nd, 2016

New Yale-developed device lengthens the life of quantum information July 22nd, 2016

RMIT researchers make leap in measuring quantum states July 21st, 2016

Lab-on-a-chip

POSTECH researchers develop a control algorithm for more accurate lab-on-a-chip devices April 6th, 2016

Artificial molecules April 3rd, 2016

New microwave imaging approach opens a nanoscale view on processes in liquids: Technique can explore technologically and medically important processes that occur at boundaries between liquids and solids, such as in batteries or along cell membranes March 16th, 2016

Nanoworld 'snow blowers' carve straight channels in semiconductor surfaces: NIST, IBM researchers report important addition to toolkit of 'self-assembly' methods eyed for making useful devices December 28th, 2015

Discoveries

Nanoparticle versus cancer: Scientists have created nanoparticles which cure cancer harmlessly July 22nd, 2016

Quantum drag:University of Iowa physicist says current in one iron magnetic sheet can create quantized spin waves in another, separate sheet July 22nd, 2016

New Yale-developed device lengthens the life of quantum information July 22nd, 2016

Research team led by NUS scientists develop plastic flexible magnetic memory device: Novel technique to implant high-performance magnetic memory chip on a flexible plastic surface without compromising performance July 21st, 2016

Announcements

Nanoparticle versus cancer: Scientists have created nanoparticles which cure cancer harmlessly July 22nd, 2016

Quantum drag:University of Iowa physicist says current in one iron magnetic sheet can create quantized spin waves in another, separate sheet July 22nd, 2016

New Yale-developed device lengthens the life of quantum information July 22nd, 2016

Graphene photodetectors: Thinking outside the 2-D box July 21st, 2016

Interviews/Book Reviews/Essays/Reports/Podcasts/Journals/White papers

Nanoparticle versus cancer: Scientists have created nanoparticles which cure cancer harmlessly July 22nd, 2016

Quantum drag:University of Iowa physicist says current in one iron magnetic sheet can create quantized spin waves in another, separate sheet July 22nd, 2016

New Yale-developed device lengthens the life of quantum information July 22nd, 2016

Graphene photodetectors: Thinking outside the 2-D box July 21st, 2016

Tools

The birth of quantum holography: Making holograms of single light particles! July 21st, 2016

A glimpse inside the atom: Using electron microscopes, it is possible to image individual atoms July 20th, 2016

Nanometrics Announces Upcoming Investor Events July 20th, 2016

A mini-antenna for the data processing of tomorrow: Nature Nanotechnology: Short-wavelength spin waves generated directly for the first time July 20th, 2016

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







Car Brands
Buy website traffic