Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Targeting tumors using silver nanoparticles: A new platform developed at UCSB increases the efficiency of drug delivery and allows excess particles to be washed away

Prostate cancer cells were targeted by two separate silver nanoparticles (red and green), while the cell nucleus was labeled in blueusing Hoescht dye.

Credit: UCSB
Prostate cancer cells were targeted by two separate silver nanoparticles (red and green), while the cell nucleus was labeled in blueusing Hoescht dye.

Credit: UCSB

Abstract:
Scientists at UC Santa Barbara have designed a nanoparticle that has a couple of unique — and important — properties. Spherical in shape and silver in composition, it is encased in a shell coated with a peptide that enables it to target tumor cells. What's more, the shell is etchable so those nanoparticles that don't hit their target can be broken down and eliminated. The research findings appear today in the journal Nature Materials.

Targeting tumors using silver nanoparticles: A new platform developed at UCSB increases the efficiency of drug delivery and allows excess particles to be washed away

Santa Barbara, CA | Posted on June 8th, 2014

The core of the nanoparticle employs a phenomenon called plasmonics. In plasmonics, nanostructured metals such as gold and silver resonate in light and concentrate the electromagnetic field near the surface. In this way, fluorescent dyes are enhanced, appearing about tenfold brighter than their natural state when no metal is present. When the core is etched, the enhancement goes away and the particle becomes dim.

UCSB's Ruoslahti Research Laboratory also developed a simple etching technique using biocompatible chemicals to rapidly disassemble and remove the silver nanoparticles outside living cells. This method leaves only the intact nanoparticles for imaging or quantification, thus revealing which cells have been targeted and how much each cell internalized.

"The disassembly is an interesting concept for creating drugs that respond to a certain stimulus," said Gary Braun, a postdoctoral associate in the Ruoslahti Lab in the Department of Molecular, Cellular and Developmental Biology (MCDB). "It also minimizes the off-target toxicity by breaking down the excess nanoparticles so they can then be cleared through the kidneys."

This method for removing nanoparticles unable to penetrate target cells is unique. "By focusing on the nanoparticles that actually got into cells," Braun said, "we can then understand which cells were targeted and study the tissue transport pathways in more detail."

Some drugs are able to pass through the cell membrane on their own, but many drugs, especially RNA and DNA genetic drugs, are charged molecules that are blocked by the membrane. These drugs must be taken in through endocytosis, the process by which cells absorb molecules by engulfing them.

"This typically requires a nanoparticle carrier to protect the drug and carry it into the cell," Braun said. "And that's what we measured: the internalization of a carrier via endocytosis."

Because the nanoparticle has a core shell structure, the researchers can vary its exterior coating and compare the efficiency of tumor targeting and internalization. Switching out the surface agent enables the targeting of different diseases — or organisms in the case of bacteria — through the use of different target receptors. According to Braun, this should turn into a way to optimize drug delivery where the core is a drug-containing vehicle.

"These new nanoparticles have some remarkable properties that have already proven useful as a tool in our work that relates to targeted drug delivery into tumors," said Erkki Ruoslahti, adjunct distinguished professor in UCSB's Center for Nanomedicine and MCDB department. "They also have potential applications in combating infections. Dangerous infections caused by bacteria that are resistant to all antibiotics are getting more common, and new approaches to deal with this problem are desperately needed. Silver is a locally used antibacterial agent and our targeting technology may make it possible to use silver nanoparticles in treating infections anywhere in the body."

####

For more information, please click here

Contacts:
Julie Cohen

805-893-7220

Copyright © University of California - Santa Barbara

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Research Study: MetaSOLTM Shatters Solar Panel Efficiency Forecasts with Innovative New Coating: Coating Provides 1.2 Percent Absolute Enhancement to Triple Junction Solar Cells December 2nd, 2016

Deep insights from surface reactions: Researchers use Stampede supercomputer to study new chemical sensing methods, desalination and bacterial energy production December 2nd, 2016

Quantum obstacle course changes material from superconductor to insulator December 1st, 2016

Throwing new light on printed organic solar cells December 1st, 2016

Nanomedicine

Nanobiotix Provides Update on Global Development of Lead Product NBTXR3: Seven clinical trials across the world: More than 2/3 of STS patients recruited in the “act.in.sarc” Phase II/III trial: Phase I/II prostate cancer trial now recruiting in the U.S. November 28th, 2016

From champagne bubbles, dance parties and disease to new nanomaterials: Understanding nucleation of protein filaments might help with Alzheimer's Disease and type 2 Diabetes November 24th, 2016

Nanopolymer-modified protein array can pinpoint hard-to-find cancer biomarker November 17th, 2016

Nanotechnology Treatment Found to Inhibit Mesothelioma Tumor Growth November 16th, 2016

Discoveries

Research Study: MetaSOLTM Shatters Solar Panel Efficiency Forecasts with Innovative New Coating: Coating Provides 1.2 Percent Absolute Enhancement to Triple Junction Solar Cells December 2nd, 2016

Deep insights from surface reactions: Researchers use Stampede supercomputer to study new chemical sensing methods, desalination and bacterial energy production December 2nd, 2016

Quantum obstacle course changes material from superconductor to insulator December 1st, 2016

Throwing new light on printed organic solar cells December 1st, 2016

Materials/Metamaterials

Inside tiny tubes, water turns solid when it should be boiling: MIT researchers discover astonishing behavior of water confined in carbon nanotubes November 30th, 2016

From champagne bubbles, dance parties and disease to new nanomaterials: Understanding nucleation of protein filaments might help with Alzheimer's Disease and type 2 Diabetes November 24th, 2016

Uncovering the secrets of friction on graphene: Sliding on flexible graphene surfaces has been uncharted territory until now November 23rd, 2016

2-D material a brittle surprise: Rice University researchers finds molybdenum diselenide not as strong as they thought November 14th, 2016

Announcements

Research Study: MetaSOLTM Shatters Solar Panel Efficiency Forecasts with Innovative New Coating: Coating Provides 1.2 Percent Absolute Enhancement to Triple Junction Solar Cells December 2nd, 2016

Deep insights from surface reactions: Researchers use Stampede supercomputer to study new chemical sensing methods, desalination and bacterial energy production December 2nd, 2016

Quantum obstacle course changes material from superconductor to insulator December 1st, 2016

Throwing new light on printed organic solar cells December 1st, 2016

Interviews/Book Reviews/Essays/Reports/Podcasts/Journals/White papers

Deep insights from surface reactions: Researchers use Stampede supercomputer to study new chemical sensing methods, desalination and bacterial energy production December 2nd, 2016

Quantum obstacle course changes material from superconductor to insulator December 1st, 2016

Throwing new light on printed organic solar cells December 1st, 2016

New method for analyzing crystal structure: Exotic materials called photonic crystals reveal their internal characteristics with new method November 30th, 2016

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project