Nanotechnology Now

Our NanoNews Digest Sponsors
Heifer International

Wikipedia Affiliate Button

Home > Press > Nanoshell-emitters hybrid nanoobject was proposed as promising 2-photon fluorescence probe

This is a schematic presentation of plasmonic-enhanced two-photon fluorescence of a single emitter inside or outside of an individual gold nanoshell.

Credit: ©Science China Press
This is a schematic presentation of plasmonic-enhanced two-photon fluorescence of a single emitter inside or outside of an individual gold nanoshell.

Credit: ©Science China Press

Abstract:
Two-photon excitation fluorescence is growing in popularity in the bioimaging field but is limited by fluorophores' extremely low two-photon absorption cross-section. The researcher Dr. Guowei Lu and co-workers from State Key Laboratory for Mesoscopic Physics, Department of Physics, Peking University, are endeavoring to develop efficient fluorescent probes with improved two-photon fluorescence (TPF) performance. They theoretically present a promising bright probe using gold nanoshell to improve the TPF performances of fluorescent emitters. Their work, entitled "Plasmonic-Enhanced Two-Photon Fluorescence with Single Gold Nanoshell", was published in SCIENCE CHINA Physics, Mechanics & Astronomy.2014, Vol 57(6).

Nanoshell-emitters hybrid nanoobject was proposed as promising 2-photon fluorescence probe

Shenyang, PR China | Posted on May 22nd, 2014

The strategy of using metallic nanoparticles to achieve the TPF enhancement is an appealing scheme so-called metal-enhanced fluorescence. It is based on the coupling of the fluorophores and the plasmonic nanoparticles, resulting in enhanced fluorescence intensity, shortened fluorescence lifetime, and extended photostability. Specifically, the fluorescence enhancement can be optimally controlled through simultaneous efficient coupling between the excitation and emission processes of emitters and the dipolar and quadrupolar modes of the nanoparticles, respectively.

Among various types of metal nanoparticles, metallic nanoshells are especially suitable as the carriers of fluorescent emitters to construct hybrid TPF probes, because their plasmon resonance bands easily span the near-infrared region where biological tissues display minimal autofluorescence and absorption. The nanoshells act as optical antenna enabling the local field enhancement, the increase in radiative decay rate of the fluorophore that alters the quantum efficiency, and modulation of the far-field radiative coupling of fluorescence emission through nanoparticle scattering. Also, the core shell structure offers a perfect platform for designing and fabricating multifunctional nanoparticles.

The Peking University researchers employed the finite-difference time-domain method to systematically evaluate the two-photo fluorescence behavior of single emitter single nanoshell configuration. Simultaneous excitation and emission enhancements could be achieved by the suitable dimensions of the nanoshell. They found that the emitter located inside or outside the nanoshell at various positions led to significantly different enhancement effect. (as shown in the Figure).

The fluorescent emitter placed outside the nanoshell can achieve large fluorescence intensity given that both the position and orientation of the emission dipole are optimally controlled, but the TPF enhancement decays rapidly with the increase of distance between the emitter and the shell surface. In contrast, for the case of the emitter placed inside the nanoshell, it can experience substantial two-photon fluorescence enhancement without strict requirements upon the position and dipole orientations, the radiative light can be coupled efficiently with the far field. Besides, the metal shell protects the encapsulated fluorophores from the external environment. The stability of fluorophores can be improved by the strong coupling between the fluorophores and the nanoshell resulting in a shorter fluorescence lifetime. These considerations imply that fluorophores encapsulated in metallic nanoshells is a more desirable nanocomposite configuration for the TPF probe in bioimaging applications.

This work provides a comprehensive understanding about the plasmonic-enhanced two-photon fluorescence behaviors, and the nanocomposite configuration has great potential for optical detecting, imaging and sensing in biological applications.

###

The paper's co-authors are Peking University graduate students Zhang Tianyue, Shen Hongming and collaborative scientists Perriat, P.; Martini, M.; Tillement, O. from CNRS, France. This research project was supported by a grant from the National Natural Science Foundation of China and the National Key Basic Research Program of China.

####

For more information, please click here

Contacts:
LU Guowei

Copyright © Science China Press

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

See the article: ZHANG TianYue, LU GuoWei, SHEN HongMing, Perriat P, Martini M, Tillement O, GONG QiHuang. Plasmonic-enhanced two-photon fluorescence with single gold nanoshell. SCIENCE CHINA Physics, Mechanics & Astronomy, 2014, 57 (6): 1038-1045:

Related News Press

News and information

Fish-Inspired Material Changes Color Using Nanocolumns March 18th, 2019

New method to reduce uranium concentration in contaminated water March 18th, 2019

Converting biomass by applying mechanical force Nanoscientists discover new mechanism to cleave cellulose effectively and in an environmentally friendly way March 15th, 2019

Exotic “second sound” phenomenon observed in pencil lead: At relatively balmy temperatures, heat behaves like sound when moving through graphite, study reports March 15th, 2019

Imaging

Quantum sensing method measures minuscule magnetic fields: MIT researchers find a new way to make nanoscale measurements of fields in more than one dimension March 15th, 2019

Lightweight metal foams become bone hard and explosion proof after being nanocoated March 14th, 2019

New optical imaging system could be deployed to find tiny tumors: Near-infrared technology pinpoints fluorescent probes deep within living tissue; may be used to detect cancer earlier March 8th, 2019

New blueprint for understanding, predicting and optimizing complex nanoparticles: Guidelines have the potential to transform the fields of optoelectronics, bio-imaging and energy harvesting March 1st, 2019

Sensors

Quantum sensing method measures minuscule magnetic fields: MIT researchers find a new way to make nanoscale measurements of fields in more than one dimension March 15th, 2019

Oxford Instruments and partners launch EU Horizon 2020 project ULISSES: Air sensors for everyone, everywhere March 7th, 2019

With nanopore sensing, VCU physics researchers detect subtle changes in single particles: The researchers' findings 'open the door to observe all kinds of interesting phenomenon on nanosurfaces,' an area of great interest to chemists February 21st, 2019

CEA-Leti & Stanford Target Edge-AI Apps with Breakthrough Memory Cell: Paper at ISSCC 2019 Presents Proof-of-Concept Multi-Bit Chip That Overcomes NVM’s Read/Write, Latency and Integration Challenges February 20th, 2019

Discoveries

Fish-Inspired Material Changes Color Using Nanocolumns March 18th, 2019

New method to reduce uranium concentration in contaminated water March 18th, 2019

Review of the recent advances of 2D nanomaterials in Lit-ion batteries March 15th, 2019

Converting biomass by applying mechanical force Nanoscientists discover new mechanism to cleave cellulose effectively and in an environmentally friendly way March 15th, 2019

Announcements

Fish-Inspired Material Changes Color Using Nanocolumns March 18th, 2019

New method to reduce uranium concentration in contaminated water March 18th, 2019

Converting biomass by applying mechanical force Nanoscientists discover new mechanism to cleave cellulose effectively and in an environmentally friendly way March 15th, 2019

Exotic “second sound” phenomenon observed in pencil lead: At relatively balmy temperatures, heat behaves like sound when moving through graphite, study reports March 15th, 2019

Interviews/Book Reviews/Essays/Reports/Podcasts/Journals/White papers

Fish-Inspired Material Changes Color Using Nanocolumns March 18th, 2019

New method to reduce uranium concentration in contaminated water March 18th, 2019

Review of the recent advances of 2D nanomaterials in Lit-ion batteries March 15th, 2019

Converting biomass by applying mechanical force Nanoscientists discover new mechanism to cleave cellulose effectively and in an environmentally friendly way March 15th, 2019

Nanobiotechnology

Arrowhead Pharmaceuticals Begins Dosing in Phase 1 Study of ARO-APOC3 for Treatment of Hypertriglyceridemia March 11th, 2019

Computer-designed vaccine elicits potent antibodies against RSV: The nanoparticle platform for this respiratory syncytial virus study will be applied to vaccine research on flu, HIV, and more; Seattle startup Icosavax will advance related clinical trials March 8th, 2019

Nanotechnology Gives Mice Night Vision—Are Humans Next? March 2nd, 2019

CEA-Leti Breakthrough Opens Path to New Vaccine for HIV: Lipidots Platform Strengthens Immune Response to Protein That Is Key to HIV Vaccine; Results Presented in Nature Publishing Group’s npj Vaccines February 27th, 2019

Photonics/Optics/Lasers

New blueprint for understanding, predicting and optimizing complex nanoparticles: Guidelines have the potential to transform the fields of optoelectronics, bio-imaging and energy harvesting March 1st, 2019

Hybrid material may outperform graphene in several applications: A structure comprising a molybdenum disulfide monolayer on an azobenzene substrate could be used to build a highly compactable and malleable quasi-two-dimensional transistor powered by light February 28th, 2019

Researchers move closer to practical photonic quantum computing: New method fills critical need to measure large-scale quantum correlation of single photons February 28th, 2019

AIM Photonics Attends OFC 2019—the Optical Networking and Communication Conference & Exhibition to Share World-Class Capabilities and Partnership Opportunity Updates February 28th, 2019

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project