Nanotechnology Now







Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > Nanosponge decoy fights superbug infections: A good disguise enables the nanosponge to soak up toxins from drug-resistant infections or poisons

Cancers are notorious for secreting chemicals that confuse the immune system and thwart biological defenses. Researchers at Yale University have developed a novel system to simultaneously deliver a sustained dose of both an immune-system booster and a chemical to counter the cancer's secretions, resulting in a powerful therapy that, in mice, delayed tumor growth, sent tumors into remission and dramatically increased survival rates. The new immunotherapy incorporates well-studied drugs, but delivers them using nanolipogels (NLGs), a new drug transport technology the researchers designed. 
Credit: Nicolle Rager Fuller, National Science Foundation
Cancers are notorious for secreting chemicals that confuse the immune system and thwart biological defenses. Researchers at Yale University have developed a novel system to simultaneously deliver a sustained dose of both an immune-system booster and a chemical to counter the cancer's secretions, resulting in a powerful therapy that, in mice, delayed tumor growth, sent tumors into remission and dramatically increased survival rates. The new immunotherapy incorporates well-studied drugs, but delivers them using nanolipogels (NLGs), a new drug transport technology the researchers designed.

Credit: Nicolle Rager Fuller, National Science Foundation

Abstract:
Our first instinct with infection in the body is often to find it and get rid of it! But, engineer Liangfang Zhang had another idea. With support from the National Science Foundation (NSF), Zhang and his team at the University of California, San Diego (UCSD), have created a nanosponge to combat drug-resistant infections, such as those caused by Methicillin-resistant Staphylococcus aureus (MRSA).

Nanosponge decoy fights superbug infections: A good disguise enables the nanosponge to soak up toxins from drug-resistant infections or poisons

Arlington, VA | Posted on April 28th, 2014

The nanosponge, made from biocompatible, biodegradable polymer nanoparticles, is camouflaged with a red blood cell membrane. It circulates in the bloodstream, absorbing the toxins produced by infection. One red blood cell membrane can be used as a cloak for more than 3,000 of these stealthy nanosponges. Once the nanosponges are fully loaded with toxins, they are safely disposed of by the liver. They are designed to work with any type of infection or poison that attacks the cellular membrane.

Zhang is working closely with doctors and students at the UCSD Moores Cancer Center on this "nano" approach to tackling infections. He has been testing his approach on mice, with nearly a 100 percent success rate against staph infections. Human clinical trials are the next step!

The research in this episode was funded by NSF award #1216461, EAGER: Red Blood Cell Membrane Camouflaged Nanoparticles for Drug Delivery.

####

For more information, please click here

Contacts:
Miles O'Brien
Science Nation Correspondent


Marsha Walton
Science Nation Producer

Copyright © National Science Foundation (NSF)

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

How to maximize the superconducting critical temperature in a molecular superconductor: International team led by Tohoku University opens new route for discovering high Tc superconductors April 19th, 2015

Engineer improves rechargeable batteries with MoS2 nano 'sandwich' April 18th, 2015

Nanocomposites Play Effective Role in Production of Smart Fibers April 18th, 2015

Dais Analytic Corporation Appoints Eliza Wang to Board of Directors: Company's Newest Director Brings Expertise in Commercial and Legal Matters Both in the United States and China; Joins on the Heels of Successful Business Development Trade Mission to China April 18th, 2015

Videos/Movies

Light in a spin: Researchers demonstrate angular accelerating light April 15th, 2015

Deben reports on the research of Dr Sunita Ho from UCSF using a CCT500 tensile stage to study the behaviour of dental materials April 14th, 2015

Promising future of quantum dots explored in conference: ‘20 Years of Quantum Dots at Los Alamos’ runs April 12-16 April 13th, 2015

A KAIST research team develops a hyper-stretchable elastic-composite energy harvester April 13th, 2015

Govt.-Legislation/Regulation/Funding/Policy

Engineer improves rechargeable batteries with MoS2 nano 'sandwich' April 18th, 2015

New Biological Nano-Fertilizers Presented in Iran as Appropriate Replacements for Chemical Fertilizers April 18th, 2015

Beyond the lithium ion -- a significant step toward a better performing battery April 18th, 2015

Oxford Instruments commissions high field outsert magnet system for the National High Magnetic Field Laboratory 32 Tesla magnet program April 17th, 2015

Nanomedicine

Optical resonance-based biosensors designed for medical applications April 18th, 2015

Nanocomposites Play Effective Role in Production of Smart Fibers April 18th, 2015

Novel nanoparticles could save soldiers' lives after explosions April 15th, 2015

Nanoparticles at specific temperature stimulate antitumor response: Dartmouth researchers identify precise heat to boost immune system against cancer tumors April 14th, 2015

Discoveries

How to maximize the superconducting critical temperature in a molecular superconductor: International team led by Tohoku University opens new route for discovering high Tc superconductors April 19th, 2015

Optical resonance-based biosensors designed for medical applications April 18th, 2015

Iranian Foodstuff, Agricultural Industries Welcome Nanotechnology Packaging Bags April 18th, 2015

Nanocomposites Play Effective Role in Production of Smart Fibers April 18th, 2015

Announcements

How to maximize the superconducting critical temperature in a molecular superconductor: International team led by Tohoku University opens new route for discovering high Tc superconductors April 19th, 2015

Iranian Foodstuff, Agricultural Industries Welcome Nanotechnology Packaging Bags April 18th, 2015

Nanocomposites Play Effective Role in Production of Smart Fibers April 18th, 2015

Dais Analytic Corporation Appoints Eliza Wang to Board of Directors: Company's Newest Director Brings Expertise in Commercial and Legal Matters Both in the United States and China; Joins on the Heels of Successful Business Development Trade Mission to China April 18th, 2015

Nanobiotechnology

Protein Building Blocks for Nanosystems: Scientists develop method for producing bio-based materials with new properties April 17th, 2015

Study shows novel pattern of electrical charge movement through DNA April 14th, 2015

UAB researchers develop a harmless artificial virus for gene therapy April 8th, 2015

Pavel Levkin Is Granted Heinz Maier-Leibnitz Prize April 8th, 2015

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More










ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2015 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE