Nanotechnology Now

Our NanoNews Digest Sponsors


Heifer International

Wikipedia Affiliate Button

Home > Press > Nanosponge decoy fights superbug infections: A good disguise enables the nanosponge to soak up toxins from drug-resistant infections or poisons

Cancers are notorious for secreting chemicals that confuse the immune system and thwart biological defenses. Researchers at Yale University have developed a novel system to simultaneously deliver a sustained dose of both an immune-system booster and a chemical to counter the cancer's secretions, resulting in a powerful therapy that, in mice, delayed tumor growth, sent tumors into remission and dramatically increased survival rates. The new immunotherapy incorporates well-studied drugs, but delivers them using nanolipogels (NLGs), a new drug transport technology the researchers designed. 
Credit: Nicolle Rager Fuller, National Science Foundation
Cancers are notorious for secreting chemicals that confuse the immune system and thwart biological defenses. Researchers at Yale University have developed a novel system to simultaneously deliver a sustained dose of both an immune-system booster and a chemical to counter the cancer's secretions, resulting in a powerful therapy that, in mice, delayed tumor growth, sent tumors into remission and dramatically increased survival rates. The new immunotherapy incorporates well-studied drugs, but delivers them using nanolipogels (NLGs), a new drug transport technology the researchers designed.

Credit: Nicolle Rager Fuller, National Science Foundation

Abstract:
Our first instinct with infection in the body is often to find it and get rid of it! But, engineer Liangfang Zhang had another idea. With support from the National Science Foundation (NSF), Zhang and his team at the University of California, San Diego (UCSD), have created a nanosponge to combat drug-resistant infections, such as those caused by Methicillin-resistant Staphylococcus aureus (MRSA).

Nanosponge decoy fights superbug infections: A good disguise enables the nanosponge to soak up toxins from drug-resistant infections or poisons

Arlington, VA | Posted on April 28th, 2014

The nanosponge, made from biocompatible, biodegradable polymer nanoparticles, is camouflaged with a red blood cell membrane. It circulates in the bloodstream, absorbing the toxins produced by infection. One red blood cell membrane can be used as a cloak for more than 3,000 of these stealthy nanosponges. Once the nanosponges are fully loaded with toxins, they are safely disposed of by the liver. They are designed to work with any type of infection or poison that attacks the cellular membrane.

Zhang is working closely with doctors and students at the UCSD Moores Cancer Center on this "nano" approach to tackling infections. He has been testing his approach on mice, with nearly a 100 percent success rate against staph infections. Human clinical trials are the next step!

The research in this episode was funded by NSF award #1216461, EAGER: Red Blood Cell Membrane Camouflaged Nanoparticles for Drug Delivery.

####

For more information, please click here

Contacts:
Miles O'Brien
Science Nation Correspondent


Marsha Walton
Science Nation Producer

Copyright © National Science Foundation (NSF)

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

New flexible material can make any window 'smart' August 23rd, 2016

University of Puerto Rico and NASA back in the news XEI reports August 23rd, 2016

Nanoparticles that speed blood clotting may someday save lives August 23rd, 2016

Spider silk: Mother Nature's bio-superlens August 22nd, 2016

Videos/Movies

Scientists uncover origin of high-temperature superconductivity in copper-oxide compound: Analysis of thousands of samples reveals that the compound becomes superconducting at an unusually high temperature because local electron pairs form a 'superfluid' that flows without resist August 19th, 2016

Argonne discovery yields self-healing diamond-like carbon August 7th, 2016

Diamond-based light sources will lay a foundation for quantum communications of the future: Electrified quantum diamond can become the heart of quantum networks and computers of the future August 7th, 2016

Project to help bring widespread use of micro-robotics August 3rd, 2016

Govt.-Legislation/Regulation/Funding/Policy

New flexible material can make any window 'smart' August 23rd, 2016

Researchers reduce expensive noble metals for fuel cell reactions August 22nd, 2016

Spider silk: Mother Nature's bio-superlens August 22nd, 2016

A new way to display the 3-D structure of molecules: Metal-organic frameworks provide a new platform for solving the structure of hard-to-study samples August 21st, 2016

Nanomedicine

Nanoparticles that speed blood clotting may someday save lives August 23rd, 2016

A new way to display the 3-D structure of molecules: Metal-organic frameworks provide a new platform for solving the structure of hard-to-study samples August 21st, 2016

Curbing the life-long effects of traumatic brain injury August 19th, 2016

Lab team spins ginger into nanoparticles to heal inflammatory bowel disease August 19th, 2016

Discoveries

New flexible material can make any window 'smart' August 23rd, 2016

Nanoparticles that speed blood clotting may someday save lives August 23rd, 2016

Researchers reduce expensive noble metals for fuel cell reactions August 22nd, 2016

Spider silk: Mother Nature's bio-superlens August 22nd, 2016

Announcements

New flexible material can make any window 'smart' August 23rd, 2016

University of Puerto Rico and NASA back in the news XEI reports August 23rd, 2016

Nanoparticles that speed blood clotting may someday save lives August 23rd, 2016

Researchers reduce expensive noble metals for fuel cell reactions August 22nd, 2016

Nanobiotechnology

Nanoparticles that speed blood clotting may someday save lives August 23rd, 2016

A new way to display the 3-D structure of molecules: Metal-organic frameworks provide a new platform for solving the structure of hard-to-study samples August 21st, 2016

Curbing the life-long effects of traumatic brain injury August 19th, 2016

Lab team spins ginger into nanoparticles to heal inflammatory bowel disease August 19th, 2016

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







Car Brands
Buy website traffic