Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > Nanosponge decoy fights superbug infections: A good disguise enables the nanosponge to soak up toxins from drug-resistant infections or poisons

Cancers are notorious for secreting chemicals that confuse the immune system and thwart biological defenses. Researchers at Yale University have developed a novel system to simultaneously deliver a sustained dose of both an immune-system booster and a chemical to counter the cancer's secretions, resulting in a powerful therapy that, in mice, delayed tumor growth, sent tumors into remission and dramatically increased survival rates. The new immunotherapy incorporates well-studied drugs, but delivers them using nanolipogels (NLGs), a new drug transport technology the researchers designed. 
Credit: Nicolle Rager Fuller, National Science Foundation
Cancers are notorious for secreting chemicals that confuse the immune system and thwart biological defenses. Researchers at Yale University have developed a novel system to simultaneously deliver a sustained dose of both an immune-system booster and a chemical to counter the cancer's secretions, resulting in a powerful therapy that, in mice, delayed tumor growth, sent tumors into remission and dramatically increased survival rates. The new immunotherapy incorporates well-studied drugs, but delivers them using nanolipogels (NLGs), a new drug transport technology the researchers designed.

Credit: Nicolle Rager Fuller, National Science Foundation

Abstract:
Our first instinct with infection in the body is often to find it and get rid of it! But, engineer Liangfang Zhang had another idea. With support from the National Science Foundation (NSF), Zhang and his team at the University of California, San Diego (UCSD), have created a nanosponge to combat drug-resistant infections, such as those caused by Methicillin-resistant Staphylococcus aureus (MRSA).

Nanosponge decoy fights superbug infections: A good disguise enables the nanosponge to soak up toxins from drug-resistant infections or poisons

Arlington, VA | Posted on April 28th, 2014

The nanosponge, made from biocompatible, biodegradable polymer nanoparticles, is camouflaged with a red blood cell membrane. It circulates in the bloodstream, absorbing the toxins produced by infection. One red blood cell membrane can be used as a cloak for more than 3,000 of these stealthy nanosponges. Once the nanosponges are fully loaded with toxins, they are safely disposed of by the liver. They are designed to work with any type of infection or poison that attacks the cellular membrane.

Zhang is working closely with doctors and students at the UCSD Moores Cancer Center on this "nano" approach to tackling infections. He has been testing his approach on mice, with nearly a 100 percent success rate against staph infections. Human clinical trials are the next step!

The research in this episode was funded by NSF award #1216461, EAGER: Red Blood Cell Membrane Camouflaged Nanoparticles for Drug Delivery.

####

For more information, please click here

Contacts:
Miles O'Brien
Science Nation Correspondent


Marsha Walton
Science Nation Producer

Copyright © National Science Foundation (NSF)

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

East China University of Science and Technology Purchases Nanonex Advanced Nanoimprint Tool NX-B200 July 30th, 2014

Watching Schrödinger's cat die (or come to life): Steering quantum evolution & using probes to conduct continuous error correction in quantum computers July 30th, 2014

From Narrow to Broad July 30th, 2014

FLAG-ERA and TNT2014 join efforts: Graphene Networking at its higher level in Barcelona: Encourage the participation in a joint transnational call July 30th, 2014

Videos/Movies

More than glitter: Scientists explain how gold nanoparticles easily penetrate cells, making them useful for delivering drugs July 21st, 2014

"Nanocamera" takes pictures at distances smaller than light's own wavelength: How is it possible to record optically encoded information for distances smaller than the wavelength of light? July 17th, 2014

CIQUS researchers develop an extremely simple procedure to obtain nanosized graphenes July 15th, 2014

New particle-sorting method breaks speed records: Discovery could lead to new ways of detecting cancer cells or purifying contaminated water July 1st, 2014

Govt.-Legislation/Regulation/Funding/Policy

New imaging agent provides better picture of the gut July 30th, 2014

Watching Schrödinger's cat die (or come to life): Steering quantum evolution & using probes to conduct continuous error correction in quantum computers July 30th, 2014

Nature inspires a greener way to make colorful plastics July 30th, 2014

Tough foam from tiny sheets: Rice University lab uses atom-thick materials to make ultralight foam July 29th, 2014

Nanomedicine

New imaging agent provides better picture of the gut July 30th, 2014

Zenosense, Inc. July 29th, 2014

Optimum inertial design for self-propulsion: A new study investigates the effects of small but finite inertia on the propulsion of micro and nano-scale swimming machines July 29th, 2014

FEI adds Phase Plate Technology and Titan Halo TEM to its Structural Biology Product Portfolio: New solutions provide the high-quality imaging and contrast necessary to analyze the 3D structure of molecules and molecular complexes July 28th, 2014

Discoveries

New imaging agent provides better picture of the gut July 30th, 2014

Watching Schrödinger's cat die (or come to life): Steering quantum evolution & using probes to conduct continuous error correction in quantum computers July 30th, 2014

From Narrow to Broad July 30th, 2014

A new way to make microstructured surfaces: Method can produce strong, lightweight materials with specific surface properties July 29th, 2014

Announcements

University of Manchester selects Anasys AFM-IR for coatings and corrosion research July 30th, 2014

Nature inspires a greener way to make colorful plastics July 30th, 2014

Analytical solutions from Malvern Instruments support University of Wisconsin-Milwaukee researchers in understanding environmental effects of nanomaterials July 30th, 2014

FEI Unveils New Solutions for Faster Time-to-Analysis in Metals Research July 30th, 2014

Nanobiotechnology

Harris & Harris Group Invests in Unique NYC Biotech Accelerator July 29th, 2014

Seeing is bead-lieving: Rice University scientists create model 'bead-spring' chains with tunable properties July 28th, 2014

FEI adds Phase Plate Technology and Titan Halo TEM to its Structural Biology Product Portfolio: New solutions provide the high-quality imaging and contrast necessary to analyze the 3D structure of molecules and molecular complexes July 28th, 2014

Scientists Test Nanoparticle "Alarm Clock" to Awaken Immune Systems Put to Sleep by Cancer July 25th, 2014

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE