Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > Nano shake-up: UD researchers demonstrate that processing can affect size of nanocarriers for targeted drug delivery

Thomas H. Epps, III, (pictured) and Millicent Sullivan are leading a UD research team that has shown that routine processing and storage conditions can have a significant influence on the size and shape of drug nanocarriers produced from self-assembled polymers.Photo by Evan Krape
Thomas H. Epps, III, (pictured) and Millicent Sullivan are leading a UD research team that has shown that routine processing and storage conditions can have a significant influence on the size and shape of drug nanocarriers produced from self-assembled polymers.

Photo by Evan Krape

Abstract:
Significant advances have been made in chemotherapy over the past decade, but targeting drugs to cancer cells while avoiding healthy tissues continues to be a major challenge.

Nano shake-up: UD researchers demonstrate that processing can affect size of nanocarriers for targeted drug delivery

Newark, DE | Posted on April 14th, 2014

Nanotechnology has unlocked new pathways for targeted drug delivery, including the use of nanocarriers, or capsules, that can transport cargoes of small-molecule therapeutics to specific locations in the body.

The catch? These carriers are tiny, and it matters just how tiny they are. Change the size from 10 nanometers to 100 nanometers, and the drugs can end up in the wrong cells or organs and thereby damage healthy tissues.

A common assumption is that once a nanocarrier is created, it maintains its size and shape on the shelf as well as in the body.

However, recent work by a group of researchers led by Thomas H. Epps, III, and Millicent Sullivan in the Department of Chemical and Biomolecular Engineering at the University of Delaware has shown that routine procedures in handling and processing nanocarrier solutions can have a significant influence on the size and shape of these miniscule structures.

Their findings are reported in a paper, "Size Evolution of Highly Amphiphilic Macromolecular Solution Assemblies Via a Distinct Bimodal Pathway," published in Nature Communications on April 7.

Sullivan explains that chemotherapeutic agents are designed to affect processes related to cell division. Therefore, they not only kill cancer cells but also are toxic to other rapidly proliferating cells such as those in hair follicles and bone marrow. Side effects can range from hair loss to compromised immune systems.

"Our goal is to deliver drugs more selectively and specifically to cancer cells," Sullivan says. "We want to sequester the drug so that we can control when and where it has an impact."

Although there are a number of routes to creating drug-carrying nanocapsules, there is growing interest in the use of polymers for this application.

"Molecular self-assembly of polymers offers the ability to create uniform, tailorable structures of predetermined size and shape," Epps says. "The problem lies in assuming that once they're produced, they don't change."

It turns out that they do change, and very small changes can have a very large impact.

"At 75 nanometers, a nanocarrier may deliver its cargo directly to a tumor," Epps says. "But with vigorous shaking, it can grow to 150 nanometers and may accumulate in the liver or the spleen. So simple agitation can completely alter the distribution profile of the nanocarrier-drug complex in the body."

The work has significant implications for the production, storage, and use of nano-based drug delivery systems.

About the research

The researchers used a variety of experimental techniques — including cryogenic transmission electron microscopy (cryo-TEM), small angle X-ray scattering (SAXS), small angle neutron scattering (SANS), and dynamic light scattering (DLS) — to probe the effects of common preparation conditions on the long-term stability of the self-assembled structures.

The work was carried out in collaboration with the University's Center for Neutron Science and the National Institute of Standards and Technology Center for Neutron Research.

The paper was co-authored by Elizabeth Kelley, Ryan Murphy, Jonathan Seppala, Thomas Smart, and Sarah Hann.

Thomas H. Epps, III, is the Thomas and Kipp Gutshall Chair of Chemical and Biomolecular Engineering, and Millicent Sullivan is an associate professor in the Department of Chemical and Biomolecular Engineering.

Financial support for the research was provided from an Institutional Development Award (IDeA) from the National Institutes of Health, National Institute of General Medical Sciences (NIH grant P20GM103541).

Article by Diane Kukich

####

For more information, please click here

Contacts:
Andrea Boyle Tippett

302-831-1421

Copyright © University of Delaware

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

Download paper:

Related News Press

News and information

East China University of Science and Technology Purchases Nanonex Advanced Nanoimprint Tool NX-B200 July 30th, 2014

Watching Schrödinger's cat die (or come to life): Steering quantum evolution & using probes to conduct continuous error correction in quantum computers July 30th, 2014

From Narrow to Broad July 30th, 2014

FLAG-ERA and TNT2014 join efforts: Graphene Networking at its higher level in Barcelona: Encourage the participation in a joint transnational call July 30th, 2014

Govt.-Legislation/Regulation/Funding/Policy

New imaging agent provides better picture of the gut July 30th, 2014

Watching Schrödinger's cat die (or come to life): Steering quantum evolution & using probes to conduct continuous error correction in quantum computers July 30th, 2014

Nature inspires a greener way to make colorful plastics July 30th, 2014

Tough foam from tiny sheets: Rice University lab uses atom-thick materials to make ultralight foam July 29th, 2014

Nanomedicine

New imaging agent provides better picture of the gut July 30th, 2014

Zenosense, Inc. July 29th, 2014

Optimum inertial design for self-propulsion: A new study investigates the effects of small but finite inertia on the propulsion of micro and nano-scale swimming machines July 29th, 2014

FEI adds Phase Plate Technology and Titan Halo TEM to its Structural Biology Product Portfolio: New solutions provide the high-quality imaging and contrast necessary to analyze the 3D structure of molecules and molecular complexes July 28th, 2014

Discoveries

New imaging agent provides better picture of the gut July 30th, 2014

Watching Schrödinger's cat die (or come to life): Steering quantum evolution & using probes to conduct continuous error correction in quantum computers July 30th, 2014

From Narrow to Broad July 30th, 2014

A new way to make microstructured surfaces: Method can produce strong, lightweight materials with specific surface properties July 29th, 2014

Announcements

University of Manchester selects Anasys AFM-IR for coatings and corrosion research July 30th, 2014

Nature inspires a greener way to make colorful plastics July 30th, 2014

Analytical solutions from Malvern Instruments support University of Wisconsin-Milwaukee researchers in understanding environmental effects of nanomaterials July 30th, 2014

FEI Unveils New Solutions for Faster Time-to-Analysis in Metals Research July 30th, 2014

Interviews/Book Reviews/Essays/Reports/Podcasts/Journals

Watching Schrödinger's cat die (or come to life): Steering quantum evolution & using probes to conduct continuous error correction in quantum computers July 30th, 2014

From Narrow to Broad July 30th, 2014

Nature inspires a greener way to make colorful plastics July 30th, 2014

A new way to make microstructured surfaces: Method can produce strong, lightweight materials with specific surface properties July 29th, 2014

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE