Nanotechnology Now





Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > Nano shake-up: UD researchers demonstrate that processing can affect size of nanocarriers for targeted drug delivery

Thomas H. Epps, III, (pictured) and Millicent Sullivan are leading a UD research team that has shown that routine processing and storage conditions can have a significant influence on the size and shape of drug nanocarriers produced from self-assembled polymers.Photo by Evan Krape
Thomas H. Epps, III, (pictured) and Millicent Sullivan are leading a UD research team that has shown that routine processing and storage conditions can have a significant influence on the size and shape of drug nanocarriers produced from self-assembled polymers.

Photo by Evan Krape

Abstract:
Significant advances have been made in chemotherapy over the past decade, but targeting drugs to cancer cells while avoiding healthy tissues continues to be a major challenge.

Nano shake-up: UD researchers demonstrate that processing can affect size of nanocarriers for targeted drug delivery

Newark, DE | Posted on April 14th, 2014

Nanotechnology has unlocked new pathways for targeted drug delivery, including the use of nanocarriers, or capsules, that can transport cargoes of small-molecule therapeutics to specific locations in the body.

The catch? These carriers are tiny, and it matters just how tiny they are. Change the size from 10 nanometers to 100 nanometers, and the drugs can end up in the wrong cells or organs and thereby damage healthy tissues.

A common assumption is that once a nanocarrier is created, it maintains its size and shape on the shelf as well as in the body.

However, recent work by a group of researchers led by Thomas H. Epps, III, and Millicent Sullivan in the Department of Chemical and Biomolecular Engineering at the University of Delaware has shown that routine procedures in handling and processing nanocarrier solutions can have a significant influence on the size and shape of these miniscule structures.

Their findings are reported in a paper, "Size Evolution of Highly Amphiphilic Macromolecular Solution Assemblies Via a Distinct Bimodal Pathway," published in Nature Communications on April 7.

Sullivan explains that chemotherapeutic agents are designed to affect processes related to cell division. Therefore, they not only kill cancer cells but also are toxic to other rapidly proliferating cells such as those in hair follicles and bone marrow. Side effects can range from hair loss to compromised immune systems.

"Our goal is to deliver drugs more selectively and specifically to cancer cells," Sullivan says. "We want to sequester the drug so that we can control when and where it has an impact."

Although there are a number of routes to creating drug-carrying nanocapsules, there is growing interest in the use of polymers for this application.

"Molecular self-assembly of polymers offers the ability to create uniform, tailorable structures of predetermined size and shape," Epps says. "The problem lies in assuming that once they're produced, they don't change."

It turns out that they do change, and very small changes can have a very large impact.

"At 75 nanometers, a nanocarrier may deliver its cargo directly to a tumor," Epps says. "But with vigorous shaking, it can grow to 150 nanometers and may accumulate in the liver or the spleen. So simple agitation can completely alter the distribution profile of the nanocarrier-drug complex in the body."

The work has significant implications for the production, storage, and use of nano-based drug delivery systems.

About the research

The researchers used a variety of experimental techniques — including cryogenic transmission electron microscopy (cryo-TEM), small angle X-ray scattering (SAXS), small angle neutron scattering (SANS), and dynamic light scattering (DLS) — to probe the effects of common preparation conditions on the long-term stability of the self-assembled structures.

The work was carried out in collaboration with the University's Center for Neutron Science and the National Institute of Standards and Technology Center for Neutron Research.

The paper was co-authored by Elizabeth Kelley, Ryan Murphy, Jonathan Seppala, Thomas Smart, and Sarah Hann.

Thomas H. Epps, III, is the Thomas and Kipp Gutshall Chair of Chemical and Biomolecular Engineering, and Millicent Sullivan is an associate professor in the Department of Chemical and Biomolecular Engineering.

Financial support for the research was provided from an Institutional Development Award (IDeA) from the National Institutes of Health, National Institute of General Medical Sciences (NIH grant P20GM103541).

Article by Diane Kukich

####

For more information, please click here

Contacts:
Andrea Boyle Tippett

302-831-1421

Copyright © University of Delaware

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

Download paper:

Related News Press

News and information

Clues to inner atomic life from subtle light-emission shifts: Hyperfine structure of light absorption by short-lived cadmium atom isotopes reveals characteristics of the nucleus that matter for high precision detection methods July 3rd, 2015

Pioneering Southampton scientist awarded prestigious physics medal July 3rd, 2015

Groundbreaking research to help control liquids at micro and nano scales July 3rd, 2015

Discovery of nanotubes offers new clues about cell-to-cell communication July 2nd, 2015

Govt.-Legislation/Regulation/Funding/Policy

New technology using silver may hold key to electronics advances July 2nd, 2015

NIST Group Maps Distribution of Carbon Nanotubes in Composite Materials July 2nd, 2015

NIST ‘How-To’ Website Documents Procedures for Nano-EHS Research and Testing July 1st, 2015

Ultra-stable JILA microscopy technique tracks tiny objects for hours July 1st, 2015

Nanomedicine

Groundbreaking research to help control liquids at micro and nano scales July 3rd, 2015

Iranian Scientists Find Simple, Economic Method to Synthesize Antibacterial Nanoparticles July 2nd, 2015

Leti Announces Launch of First European Nanomedicine Characterisation Laboratory: Project Combines Expertise of 9 Partners in 8 Countries to Foster Nanomedicine Innovation and Facilitate Regulatory Approval July 1st, 2015

Chitosan coated, chemotherapy packed nanoparticles may target cancer stem cells June 30th, 2015

Discoveries

Clues to inner atomic life from subtle light-emission shifts: Hyperfine structure of light absorption by short-lived cadmium atom isotopes reveals characteristics of the nucleus that matter for high precision detection methods July 3rd, 2015

Groundbreaking research to help control liquids at micro and nano scales July 3rd, 2015

Producing spin-entangled electrons July 2nd, 2015

NIST Group Maps Distribution of Carbon Nanotubes in Composite Materials July 2nd, 2015

Announcements

Clues to inner atomic life from subtle light-emission shifts: Hyperfine structure of light absorption by short-lived cadmium atom isotopes reveals characteristics of the nucleus that matter for high precision detection methods July 3rd, 2015

Pioneering Southampton scientist awarded prestigious physics medal July 3rd, 2015

Groundbreaking research to help control liquids at micro and nano scales July 3rd, 2015

NIST Group Maps Distribution of Carbon Nanotubes in Composite Materials July 2nd, 2015

Interviews/Book Reviews/Essays/Reports/Podcasts/Journals/White papers

Clues to inner atomic life from subtle light-emission shifts: Hyperfine structure of light absorption by short-lived cadmium atom isotopes reveals characteristics of the nucleus that matter for high precision detection methods July 3rd, 2015

Pioneering Southampton scientist awarded prestigious physics medal July 3rd, 2015

Groundbreaking research to help control liquids at micro and nano scales July 3rd, 2015

NIST Group Maps Distribution of Carbon Nanotubes in Composite Materials July 2nd, 2015

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More










ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project