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Home > Press > Silica Nanocomposite Used in Production of pH-Sensitive Oral Drug Nanocarrier

Abstract:
Iranian researchers used modified silica nanocomposite and produced edible drug nanocarrier through a simple method which is sensitive to pH value and reduces the amount of the consumed drug and its side-effects.

Silica Nanocomposite Used in Production of pH-Sensitive Oral Drug Nanocarrier

Tehran, Iran | Posted on April 10th, 2014

The product has application in pharmaceutical industries.

Taking into consideration the huge difference between pH-values in stomach and intestine, the researchers decided to design nanocomposites that are resistant in acidic environment of stomach and their structures do not change much, but change in intestine and are able to release the loaded drug when swelling.

In this research, silicone nanoparticles were firstly produced through sol-gel method. Then, silica nanoparticles with acidic ends were produced after modifying the surface of silicone nanoparticles under controlled conditions. Finally, pH-sensitive nanocomposite was produced by adding vinyl to the acidic groups and by copolymerization of the nanoparticles.

Results showed that the produced nanocomposite based on modified silicone nanoparticles was not only sensitive to pH-value, but it also acted perfectly as a very effective carrier in drug releasing. The nanocarriers are degraded by intestine bacteria, and they can be produced through very simple methods. Moreover, the nanocarrier is able to deliver drugs to the target tissue at specified time with determined amount of drug. As a result, it significantly reduces undesirable side-effects of the drugs in comparison with primitive drug delivery systems, and therefore, it is safer and more effective.

Among other characteristics of these biocompatible composite nanocarriers, mention can be made of their ability to be loaded with a few types of medications at the same time.

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