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Iranian researchers investigated the properties of gold nanorods as the carriers for radiodrugs.
The nanorods have polymeric coating and are labeled with iodine isotope, are resistant to body immune system and remain in blood stream for a long time.
According to Dr. Soudeh Sadat Sajjadi, a member of the Scientific Board of Nuclear Science and Technology Research Institute, gold nanorods can be well used in molecular imaging and drug carrying due to their unique properties such as ease of production, optical properties, and biocompatibility. In this research, nanocarriers made of gold nanorods with a coating of polyethylene glycol (PEG) were produced and labeled with iodine-131 isotope, and its tissue distribution in the body was investigated by the researchers.
The product has applications in medical industries, specially in vivo imaging of the living creatures and in the treatment of diseases such as tumors.
Results showed that the nanocarrier remained intact a long time after being rejected by the immune system of liver, spleen, and marrow, and it stayed longer in blood stream and the related tissues, including heart and lung, in comparison with other similar nanostructures.
Modified nanorods used in this research are labeled with iondine-131 without the need for any other functional group, which is another advantage of this product. The reason is high affinity of iodine in contact with the surface of gold nanorods.
The researchers are currently trying to produce gold nanoparticles in different shapes and sizes, to label them with other radiocolloids, and to study tissue distribution of the labeled nanoparticles.
Results of the research have been published in Journal of Labelled Compounds and Radiopharmaceuticals, vol. 56, December 2012, pp. 12-16.
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