Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Fighting cancer with lasers and nanoballoons that pop

Abstract:
Chemotherapeutic drugs excel at fighting cancer, but they're not so efficient at getting where they need to go.

Fighting cancer with lasers and nanoballoons that pop

Buffalo, NY | Posted on April 3rd, 2014

They often interact with blood, bone marrow and other healthy bodily systems. This dilutes the drugs and causes unwanted side effects.

Now, researchers are developing a better delivery method by encapsulating the drugs in nanoballoons - which are tiny modified liposomes that, upon being struck by a red laser, pop open and deliver concentrated doses of medicine.

Described April 3 in the journal Nature Communications, the innovation could improve cancer treatment, reduce its side effects and boost research about the disease, which annually kills millions of people worldwide.

"Why PoP-liposomes, or nanoballoons, open in response to an otherwise harmless red laser is still a bit of a mystery to us, but we have definitely unearthed a new and unique phenomenon," said corresponding author Jonathan Lovell, PhD, UB assistant professor of biomedical engineering. "Its potential for improving how we treat cancer is immense."

Additional authors include students and a research technician at UB, as well as collaborators from the University at Albany; Roswell Park Cancer Institute in Buffalo; and the University of Waterloo and McMaster University, both in Ontario, Canada.

Roughly 1,000 times thinner than human hair, nanoballoons consist of porphyrin, an organic compound, and phospholipid, a fat similar to vegetable oil. Like conventional chemotherapy, they would be delivered to patients intravenously.

But because the nanoballoons encapsulate the anti-cancer drugs, they diminish the drugs' interaction with healthy bodily systems.

In laboratory experiments performed with mice, Lovell hits the nanoballoon with a red laser at the target site in the body. The laser triggers the nanoballoons to pop open and release the drugs. As soon as the laser is turned off, the nanoballoons close, taking in proteins and molecules that might induce cancer growth. Doctors could then be able to retrieve the nanoballoons by drawing blood or taking a biopsy.

Thus, the nanotechnology could provide a "chemical snapshot" of the tumor's environment, which otherwise is very difficult to assess.

"Think of it this way," Lovell said. "The nanoballoon is a submarine. The drug is the cargo. We use a laser to open the submarine door which releases the drug. We close the door by turning the laser off. We then retrieve the submarine as it circulates through the bloodstream."

Lovell will continue fundamental studies to better understand why the treatment works so well in destroying tumors in mice, and to optimize the process. Human trials could start within five years, he said.

###

The work is supported by the National Institutes of Health, which last year awarded Lovell grants from the National Institute of Biomedical Imaging and Bioengineering, as well as its Early Independence Award program, which funds high-risk, high-reward research.

####

For more information, please click here

Contacts:
Cory Nealon

Copyright © University at Buffalo

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Particles from outer space are wreaking low-grade havoc on personal electronics February 19th, 2017

Liquid metal nano printing set to revolutionize electronics: Creating integrated circuits just atoms thick February 18th, 2017

Engineers shrink microscope to dime-sized device February 17th, 2017

Francis Alexander Named Deputy Director of Brookhaven Lab's Computational Science Initiative February 16th, 2017

Nanomedicine

Good vibrations help reveal molecular details: Rice University scientists combine disciplines to pinpoint small structures in unlabeled molecules February 15th, 2017

In-cell molecular sieve from protein crystal February 14th, 2017

Cedars-Sinai, UCLA Scientists Use New ‘Blood Biopsies’ With Experimental Device to Speed Cancer Diagnosis and Predict Disease Spread: Leading-Edge Research Is Part of National Cancer Moonshot Initiative February 13th, 2017

Meta-lenses bring benchtop performance to small, hand-held spectrometer: Game-changing nanostructure-based lenses allow smaller devices, increased functionality February 9th, 2017

Discoveries

Particles from outer space are wreaking low-grade havoc on personal electronics February 19th, 2017

Liquid metal nano printing set to revolutionize electronics: Creating integrated circuits just atoms thick February 18th, 2017

Engineers shrink microscope to dime-sized device February 17th, 2017

Research opens door to smaller, cheaper, more agile communications tech February 16th, 2017

Announcements

Particles from outer space are wreaking low-grade havoc on personal electronics February 19th, 2017

Liquid metal nano printing set to revolutionize electronics: Creating integrated circuits just atoms thick February 18th, 2017

Engineers shrink microscope to dime-sized device February 17th, 2017

Francis Alexander Named Deputy Director of Brookhaven Lab's Computational Science Initiative February 16th, 2017

Interviews/Book Reviews/Essays/Reports/Podcasts/Journals/White papers

Particles from outer space are wreaking low-grade havoc on personal electronics February 19th, 2017

Liquid metal nano printing set to revolutionize electronics: Creating integrated circuits just atoms thick February 18th, 2017

Engineers shrink microscope to dime-sized device February 17th, 2017

Research opens door to smaller, cheaper, more agile communications tech February 16th, 2017

Photonics/Optics/Lasers

Liquid metal nano printing set to revolutionize electronics: Creating integrated circuits just atoms thick February 18th, 2017

Research opens door to smaller, cheaper, more agile communications tech February 16th, 2017

1,000 times more efficient nano-LED opens door to faster microchips February 5th, 2017

NUS engineers develop low-cost, flexible terahertz radiation source for fast, non-invasive screening: Novel invention presents promising applications in spectroscopy, safety surveillance, cancer diagnosis, imaging and communication February 1st, 2017

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project