Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > NIST microanalysis technique makes the most of small nanoparticle samples

Small piezoelectric quartz crystals are the key to micro thermogavimetric analysis. Here, minute amounts of the test sample are deposited on the crystals.

Credit: Kar/National Institute of Standards and Technology
Small piezoelectric quartz crystals are the key to micro thermogavimetric analysis. Here, minute amounts of the test sample are deposited on the crystals.

Credit: Kar/National Institute of Standards and Technology

Abstract:
Researchers from the National Institute of Standards and Technology (NIST) and the Food and Drug Administration (FDA) have demonstrated that they can make sensitive chemical analyses of minute samples of nanoparticles by, essentially, roasting them on top of a quartz crystal. The NIST-developed technique, "microscale thermogravimetric analysis," holds promise for studying nanomaterials in biology and the environment, where sample sizes often are quite small and larger-scale analysis won't work.*

NIST microanalysis technique makes the most of small nanoparticle samples

Gaithersburg, MD | Posted on February 24th, 2014

Chemical analysis of nanoparticles is a challenging task, and not just because they're small. They're also complicated. They can become coated with other materials in their environment, and the question becomes, what materials? Or they might have been engineered with a coating, perhaps to provide anchor points for drug molecules, and then the question can be, how complete is the coating? In nanoelectronics, the question may be, how pure is the sample and just what are the impurities?

Researchers have an alphabetic array of tools for this, including scanning, transmission or atomic force microscopy (SEM/TEM/AFM); dynamic light scattering (DLS); nuclear magnetic resonance (NMR); and sundry spectrometry techniques, but they all have a variety of limitations, including complex sample preparation or the difficulty of analyzing enough particles to get a statistically significant result.

On the other hand, one technique, thermogravimetric analysis (TGA) is quite straight-forward. The sample is heated and monitored for changes in mass as the temperature increases. Sudden changes in mass correlate with the energies needed to decompose, oxidize, dehydrate or otherwise chemically change components in the sample. If you have some idea of what you start with, TGA can tell you much more, but it requires pretty substantial sample sizes.

NIST's technique is essentially the same except that a small piezoelectric quartz crystal is substituted for the mass scale. A tiny amount of a nanomaterial sample deposited on the crystal dampens the crystal's resonant frequency, and as the sample grows lighter, the frequency shifts. NIST researchers originally applied it to measure the purity of carbon nanotube samples.**

In this latest paper, the research team tested the utility of microTGA on typical nanomaterial analysis problems, including assessing the purity of carbon nanotubes, determining the amount of surface-bound ligands (i.e., molecular anchors) on gold nanoparticles, and testing for the presence of PEG, a polymer commonly used in medicine on silicon oxide nanoparticles.

"Our results are a pretty close match to other techniques," reports NIST analytical chemist Elisabeth Mansfield, "but using far less of a sample."

In fact, the team reports, microTGA gets results using samples a thousand times smaller than conventional techniques. It can work with one microgram of sample and detect mass changes of less than a nanogram. "That's important because you often don't have much of a sample.," Mansfield says," If you're pulling nanoparticles out of a water sample from the environment to measure how much exists in a real world sample, you're going to have very little to work with."

"In nanomedicine, the surface chemistry is oftentimes critically important to the performance of the nanomaterial," notes FDA chemist Katherine Tyner. "When working with real life samples, we may only have a very small sample amount. MicroTGA allows us to obtain information that we otherwise would not be able to get with conventional techniques."

###

*E. Mansfield , K.M. Tyner, C.M. Poling and J.L. Blacklock. Determination of nanoparticle tsurface coatings and nanoparticle purity using microscale thermogravimetric analysis. Anal. Chem., 2014, 86 (3), pp 1478-1484 DOI: 10.1021/ac402888v.

####

About National Institute of Standards and Technology (NIST)
The National Institute of Standards and Technology (NIST) is an agency of the U.S. Department of Commerce.

For more information, please click here

Contacts:
Michael Baum

301-975-2763

Copyright © National Institute of Standards and Technology (NIST)

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

**See the November 2010 NIST story "Quartz Crystal Microbalances Enable New Microscale Analytic Technique" at:

Related News Press

News and information

Materials for the next generation of electronics and photovoltaics: MacArthur Fellow develops new uses for carbon nanotubes October 21st, 2014

Special UO microscope captures defects in nanotubes: University of Oregon chemists provide a detailed view of traps that disrupt energy flow, possibly pointing toward improved charge-carrying devices October 21st, 2014

Super stable garnet ceramics may be ideal for high-energy lithium batteries October 21st, 2014

Could I squeeze by you? Ames Laboratory scientists model molecular movement within narrow channels of mesoporous nanoparticles October 21st, 2014

Laboratories

Super stable garnet ceramics may be ideal for high-energy lithium batteries October 21st, 2014

Could I squeeze by you? Ames Laboratory scientists model molecular movement within narrow channels of mesoporous nanoparticles October 21st, 2014

Govt.-Legislation/Regulation/Funding/Policy

Materials for the next generation of electronics and photovoltaics: MacArthur Fellow develops new uses for carbon nanotubes October 21st, 2014

Special UO microscope captures defects in nanotubes: University of Oregon chemists provide a detailed view of traps that disrupt energy flow, possibly pointing toward improved charge-carrying devices October 21st, 2014

Super stable garnet ceramics may be ideal for high-energy lithium batteries October 21st, 2014

Could I squeeze by you? Ames Laboratory scientists model molecular movement within narrow channels of mesoporous nanoparticles October 21st, 2014

Nanomedicine

Detecting Cancer Earlier is Goal of Rutgers-Developed Medical Imaging Technology: Rare earth nanocrystals and infrared light can reveal small cancerous tumors and cardiovascular lesions October 21st, 2014

Design of micro and nanoparticles to improve treatments for Alzheimers and Parkinsons: At the Faculty of Pharmacy of the UPV/EHU-University of the Basque Country encapsulation techniques are being developed to deliver correctly and effectively certain drugs October 20th, 2014

Non-Toxic Nanocatalysts Open New Window for Significant Decrease in Reaction Process October 19th, 2014

European Commission opens the gate towards the implementation of Nanomedicine Translation Hub October 16th, 2014

Discoveries

Special UO microscope captures defects in nanotubes: University of Oregon chemists provide a detailed view of traps that disrupt energy flow, possibly pointing toward improved charge-carrying devices October 21st, 2014

Super stable garnet ceramics may be ideal for high-energy lithium batteries October 21st, 2014

Could I squeeze by you? Ames Laboratory scientists model molecular movement within narrow channels of mesoporous nanoparticles October 21st, 2014

Detecting Cancer Earlier is Goal of Rutgers-Developed Medical Imaging Technology: Rare earth nanocrystals and infrared light can reveal small cancerous tumors and cardiovascular lesions October 21st, 2014

Announcements

Special UO microscope captures defects in nanotubes: University of Oregon chemists provide a detailed view of traps that disrupt energy flow, possibly pointing toward improved charge-carrying devices October 21st, 2014

Super stable garnet ceramics may be ideal for high-energy lithium batteries October 21st, 2014

Could I squeeze by you? Ames Laboratory scientists model molecular movement within narrow channels of mesoporous nanoparticles October 21st, 2014

Detecting Cancer Earlier is Goal of Rutgers-Developed Medical Imaging Technology: Rare earth nanocrystals and infrared light can reveal small cancerous tumors and cardiovascular lesions October 21st, 2014

Interviews/Book Reviews/Essays/Reports/Podcasts/Journals

Special UO microscope captures defects in nanotubes: University of Oregon chemists provide a detailed view of traps that disrupt energy flow, possibly pointing toward improved charge-carrying devices October 21st, 2014

Could I squeeze by you? Ames Laboratory scientists model molecular movement within narrow channels of mesoporous nanoparticles October 21st, 2014

Detecting Cancer Earlier is Goal of Rutgers-Developed Medical Imaging Technology: Rare earth nanocrystals and infrared light can reveal small cancerous tumors and cardiovascular lesions October 21st, 2014

Nitrogen Doped Graphene Characterized by Iranian, Russian, German Scientists October 21st, 2014

Tools

Special UO microscope captures defects in nanotubes: University of Oregon chemists provide a detailed view of traps that disrupt energy flow, possibly pointing toward improved charge-carrying devices October 21st, 2014

Super stable garnet ceramics may be ideal for high-energy lithium batteries October 21st, 2014

Detecting Cancer Earlier is Goal of Rutgers-Developed Medical Imaging Technology: Rare earth nanocrystals and infrared light can reveal small cancerous tumors and cardiovascular lesions October 21st, 2014

New Grand ARM Transmission Electron Microscope Offers Highest Commercially-Available Atomic Resolution of 63 Picometers October 17th, 2014

Environment

Imaging electric charge propagating along microbial nanowires October 20th, 2014

Physicists build reversible laser tractor beam October 20th, 2014

Plastic nanoparticles also harm freshwater organisms October 18th, 2014

New Nanocomposites Help Elimination of Toxic Dyes October 15th, 2014

NanoNews-Digest
The latest news from around the world, FREE





  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE