Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > Clemson researchers develop sticky nanoparticles to fight heart disease

Abstract:
Clemson University researchers have developed nanoparticles that can deliver drugs targeting damaged arteries, a non-invasive method to fight heart disease.

Clemson researchers develop sticky nanoparticles to fight heart disease

Clemson, SC | Posted on February 19th, 2014

Heart disease is the leading cause of death in the U.S., according to the Centers for Disease Control and Prevention. One of the standard ways to treat clogged and damaged arteries currently is to implant vascular stents, which hold the vessels open and release such drugs as paclitaxel.

The researchers, led by Clemson bioengineering professor Naren Vyavahare, hope their advanced nanoparticles could be used alongside stents or in lieu of them.

"Healthy arteries have elastic fibers that provide elasticity. They are like rubber bands in the tissue that allow expansion and recoil during blood flow," Vyavahare said. "In most cardiovascular diseases, elastic fibers in arteries get damaged, creating hooks that can be used to target drugs."

The nanoparticles, coated with a sticky protein, latch onto damaged arteries and can deliver a drug to the site in slow release fashion. These nanoparticles can be engineered to deliver an array of drugs to the damaged or clogged artery, a common example being paclitaxel, which inhibits cell division and helps prevent growth of scar tissue that can clog arteries. These particles also have unique surfaces that allow prolonged circulation time, providing more opportunities for these particles to accumulate at the damage site.

"We developed nanoparticles that have antibodies on the surface that attach to diseased sites like Velcro," said Vyavahare. "Interestingly, these newly created nanoparticles only accumulate at the damaged artery, not in the healthy arteries, enabling site-specific drug delivery."

"These nanoparticles can be delivered intravenously to target injured areas and can administer drugs over longer periods of time, thus avoiding repeated surgical interventions at the disease site," said Aditi Sinha, a Clemson graduate student and lead author on a paper soon to be published in journal Nanomedicine: Nanotechnolgy, Biology and Medicine.

The work is a promising step toward new treatments for cardiovascular and other diseases. The research team is testing the nanoparticles to determine the most effective drug dosage for vascular tissue repair. This technology can have variety of applications in other diseases, such as chronic obstructive pulmonary disease, Marfan syndrome and elastic fiber-related disorders, such as aortic aneurysms.

####

About Clemson University
Ranked No. 21 among national public universities, Clemson University is a major, land-grant, science- and engineering-oriented research university that maintains a strong commitment to teaching and student success. Clemson is an inclusive, student-centered community characterized by high academic standards, a culture of collaboration, school spirit and a competitive drive to excel.

This material is based upon work supported by the National Institutes of Health under grant nos. R01HL070969-08, R21HL084267 and P20GM103444 and Hunter Endowment at Clemson University. Any opinions, findings and conclusions or recommendations expressed in this material are those of the authors and do not necessarily reflect the views of the National Institutes of Health.

For more information, please click here

Contacts:
Naren Vyavahare


864-656-5558
Aditi Sinha


Brian M. Mullen

864-656-2063

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Laboratorial Performance of Nanocomposite Membrane Improved in Water Purification July 28th, 2015

Perfect Optical Properties in Production of Aluminum Oxide Colloid Nanoparticles July 28th, 2015

Short wavelength plasmons observed in nanotubes: Berkeley Lab researchers create Ludinger liquid plasmons in metallic SWNTs July 28th, 2015

'Seeing' molecular interactions could give boost to organic electronics July 28th, 2015

Videos/Movies

Caught on camera: The first glimpse of powerful nanoparticles July 17th, 2015

A most singular nano-imaging technique: Berkeley Lab's SINGLE provides images of individual nanoparticles in solution July 16th, 2015

A 'movie' of ultrafast rotating molecules at a hundred billion per second: A quantum wave-like nature was successfully observed in rotating nitrogen molecules July 4th, 2015

Freezing single atoms to absolute zero with microwaves brings quantum technology closer: Atoms frozen to absolute zero using microwaves July 2nd, 2015

Govt.-Legislation/Regulation/Funding/Policy

Short wavelength plasmons observed in nanotubes: Berkeley Lab researchers create Ludinger liquid plasmons in metallic SWNTs July 28th, 2015

Smart hydrogel coating creates 'stick-slip' control of capillary action July 27th, 2015

Researchers predict material with record-setting melting point July 27th, 2015

Reshaping the solar spectrum to turn light to electricity: UC Riverside researchers find a way to use the infrared region of the sun's spectrum to make solar cells more efficient July 27th, 2015

Nanomedicine

Stretching the limits on conducting wires July 25th, 2015

UT Dallas nanotechnology research leads to super-elastic conducting fibers July 24th, 2015

Nanopaper as an optical sensing platform July 23rd, 2015

Albany College of Pharmacy and Health Sciences to Host One Week Symposium on Nanomedicine July 23rd, 2015

Discoveries

Laboratorial Performance of Nanocomposite Membrane Improved in Water Purification July 28th, 2015

Perfect Optical Properties in Production of Aluminum Oxide Colloid Nanoparticles July 28th, 2015

Short wavelength plasmons observed in nanotubes: Berkeley Lab researchers create Ludinger liquid plasmons in metallic SWNTs July 28th, 2015

'Seeing' molecular interactions could give boost to organic electronics July 28th, 2015

Announcements

Laboratorial Performance of Nanocomposite Membrane Improved in Water Purification July 28th, 2015

Perfect Optical Properties in Production of Aluminum Oxide Colloid Nanoparticles July 28th, 2015

Short wavelength plasmons observed in nanotubes: Berkeley Lab researchers create Ludinger liquid plasmons in metallic SWNTs July 28th, 2015

'Seeing' molecular interactions could give boost to organic electronics July 28th, 2015

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project