Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > JPK reports on the studies of adhesion forces between cancer cells at the Institute of Physiology II at the University of Münster, Germany

Mike Wälte and Dr Florian T Ludwig (white coat) with the JPK CellHesion® 200 system at the University of Münster
Mike Wälte and Dr Florian T Ludwig (white coat) with the JPK CellHesion® 200 system at the University of Münster

Abstract:
JPK Instruments, a world-leading manufacturer of nanoanalytic instrumentation for research in life sciences and soft matter, reports on the current cancer research project of Dr Florian T Ludwig at the Institute of Physiology II, University Hospital Münster, who uses a CellHesion® 200 to measure the adhesive forces between tumor cells.

JPK reports on the studies of adhesion forces between cancer cells at the Institute of Physiology II at the University of Münster, Germany

Berlin, Germany | Posted on February 18th, 2014

The Institute of Physiology II is part of the Medical Faculty of the Westfälische Wilhelms-Universität Münster. It brings together the areas of physiology, cell migration and ion transporters through the study of properties of cells on the nanoscale.

Dr Florian T Ludwig is a member of the team of Professor Albrecht Schwab and Dr Christian Stock. These researchers are interested in how ion transport across the plasma membrane affects tumor cell motility and, thus, metastasis. Occurring prior to migration and invasion, one early step of the so-called metastatic cascade is the detachment of single tumor cells or cell clusters from the primary neoplasm. This process is accompanied by a controlled loss of cell-cell adhesions caused by the release of bonds between adhesion molecules such as cadherins. Hence, the adhesion force between tumor cells might predict the tumor's malignancy. Tumor cells that exhibit low cell-cell adhesion forces would represent a highly metastatic phenotype since they detach more easily.

With the help of Mike Wälte from the group of the Head of the Institute, Professor Hans Oberleithner and Dr Hermann Schillers, Dr. Ludwig measures cell-cell adhesion forces in tumor cells. This is based on the group's distinguished expertise of nearly two decades' experience in atomic force microscopy, AFM.

For the experiments, a single tumor cell is attached to the cantilever of a JPK CellHesion® 200 system using a bionic cell adhesive. A second, adherent tumor cell is then approached with the cantilever until the two cells come into contact. After a defined contact time, the cantilever is retracted until the two cells are separated. The strength of the cell-cell bonds that formed while the cells were in contact is estimated by recording the force necessary to separate the cells. Here, the key feature of the CellHesion® 200 system is its ability of the cantilever sensor lifting system to travel more than 110 µm giving a clear benefit for the researchers whose aim is to separate two tumor cells both gently, reproducibly and efficiently without damage. With the technique described here, cell-cell adhesion forces can be quantified.

For more details about JPK's CellHesion® 200 system and applications for the bio & nano sciences, please contact JPK on +49 30533112070, visit the web site: www.jpk.com/ or see more on Facebook: www.jpk.com/facebook and on You Tube: www.youtube.com/jpkinstruments.

####

About JPK Instruments
JPK Instruments AG is a world-leading manufacturer of nanoanalytic instruments - particularly atomic force microscope (AFM) systems and optical tweezers - for a broad range of applications reaching from soft matter physics to nano-optics, from surface chemistry to cell and molecular biology. From its earliest days applying atomic force microscope (AFM) technology, JPK has recognized the opportunities provided by nanotechnology for transforming life sciences and soft matter research. This focus has driven JPK's success in uniting the worlds of nanotechnology tools and life science applications by offering cutting-edge technology and unique applications expertise. Headquartered in Berlin and with direct operations in Dresden, Cambridge (UK), Singapore, Tokyo and Paris (France), JPK maintains a global network of distributors and support centers and provides on the spot applications and service support to an ever-growing community of researchers.

For more information, please click here

Contacts:
JPK Instruments AG
Bouchéstrasse 12
Haus 2, Aufgang C
Berlin 12435
Germany
T +49 30533112070
F +49 30 5331 22555
http://www.jpk.com/


Talking Science Limited
39 de Bohun Court
Saffron Walden
Essex CB10 2BA
United Kingdom
T +44(0)1799 521881
M +44(0)7843 012997
http://www.talking-science.com/

Copyright © JPK Instruments

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

The International Space Elevator Consortium (ISEC) is proud to announce the 2014 Space Elevator Conference! This annual event will be held at the Museum of Flight in Seattle, Washington from Friday, August 22nd through Sunday, August 24th August 19th, 2014

KaSAM-2014 International Conference (September 7-10, 2014, Kathmandu, Nepal) August 19th, 2014

Success in Intracellular Imaging of Cesium Distribution in Plants Used for Cesium Absorption August 19th, 2014

Electrical engineers take major step toward photonic circuits: Team invents non-metallic metamaterial that enables them to 'compress' and contain light August 19th, 2014

Graphene rubber bands could stretch limits of current healthcare, new research finds August 19th, 2014

Imaging

Success in Intracellular Imaging of Cesium Distribution in Plants Used for Cesium Absorption August 19th, 2014

Oxford Instruments Asylum Research Receives the 2014 Microscopy Today Innovation Award for blueDrive Photothermal Excitation August 18th, 2014

Nanomedicine

Graphene rubber bands could stretch limits of current healthcare, new research finds August 19th, 2014

Interaction between Drug, DNA for Designing Anticancer Drugs Studied in Iran August 17th, 2014

Scientists fold RNA origami from a single strand: RNA origami is a new method for organizing molecules on the nanoscale. Using just a single strand of RNA, this technique can produce many complicated shapes. August 14th, 2014

Iranian Scientists Stabilize Protein on Highly Stable Electrode Surface August 14th, 2014

Discoveries

Success in Intracellular Imaging of Cesium Distribution in Plants Used for Cesium Absorption August 19th, 2014

Сalculations with Nanoscale Smart Particles August 19th, 2014

Electrical engineers take major step toward photonic circuits: Team invents non-metallic metamaterial that enables them to 'compress' and contain light August 19th, 2014

Graphene rubber bands could stretch limits of current healthcare, new research finds August 19th, 2014

Announcements

Сalculations with Nanoscale Smart Particles August 19th, 2014

Life on Mars? Implications of a newly discovered mineral-rich structure August 19th, 2014

Harris & Harris Group Letter to Shareholders on Website August 19th, 2014

Electrical engineers take major step toward photonic circuits: Team invents non-metallic metamaterial that enables them to 'compress' and contain light August 19th, 2014

Tools

Oxford Instruments Asylum Research Receives the 2014 Microscopy Today Innovation Award for blueDrive Photothermal Excitation August 18th, 2014

Laser makes microscopes way cooler: Cooling a nanowire probe with a laser could lead to substantial improvements in the sensitivity of atomic force probe microscopes August 15th, 2014

JPK reports on the use of AFM and advanced fluorescence microscopy at the University of Freiburg August 13th, 2014

Phasefocus reports on the use of their high-precision Lens Profiler for measuring contact lens thickness at the Brien Holden Vision Institute in Sydney, Australia August 13th, 2014

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE