Nanotechnology Now

Our NanoNews Digest Sponsors


Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > Toward fixing damaged hearts through tissue engineering

Scientists report building heart tissue that can transmit electrical signals, a key function of cardiac muscle.
Credit: Emir Simsek/iStock/Thinkstock
Scientists report building heart tissue that can transmit electrical signals, a key function of cardiac muscle.

Credit: Emir Simsek/iStock/Thinkstock

Abstract:
In the U.S., someone suffers a heart attack every 34 seconds — their heart is starved of oxygen and suffers irreparable damage. Engineering new heart tissue in the laboratory that could eventually be implanted into patients could help, and scientists are reporting a promising approach tested with rat cells. They published their results on growing cardiac muscle using a scaffold containing carbon nanofibers in the ACS journal Biomacromolecules.

Toward fixing damaged hearts through tissue engineering

Washington, DC | Posted on January 22nd, 2014

Gordana Vunjak-Novakovic, Rui L. Reis, Ana Martins and colleagues point out that when damaged, adult heart tissue can't heal itself very well. The only way to fix an injured heart is with a transplant. But within the past decade, interest in regenerating just the lost tissue has surged. The trick is to find materials that, among other things, are nontoxic, won't get attacked by the body's immune system and allow for muscle cells to pass the electrical signals necessary for the heart to beat. Previous research has found that chitosan, which is obtained from shrimp and other crustacean shells, nearly fits the bill. In lab tests, scientists have used it as a scaffold for growing heart cells. But it doesn't transmit electrical signals well. Vunjak-Novakovic's team decided to build on the chitosan development and coax it to function more like a real heart.

To the chitosan, they added carbon nanofibers, which can conduct electricity, and grew neonatal rat heart cells on the resulting scaffold. After two weeks, cells had filled all the pores and showed far better metabolic and electrical activity than with a chitosan scaffold alone. The cells on the chitosan/carbon scaffold also expressed cardiac genes at higher levels.

###

The authors acknowledge funding from Fundação para a Ciência e Tecnologia, POPH-QREN—Advanced Formation, the European Social Fund, the National Fund and the National Institutes of Health. The work was a collaboration between Columbia University and 3B´s - University of Minho, Portugal.

####

About American Chemical Society
The American Chemical Society is a nonprofit organization chartered by the U.S. Congress. With more than 163,000 members, ACS is the world's largest scientific society and a global leader in providing access to chemistry-related research through its multiple databases, peer-reviewed journals and scientific conferences. Its main offices are in Washington, D.C., and Columbus, Ohio.

For more information, please click here

Contacts:
Gordana Vunjak-Novakovic, Ph.D.
Biomedical Engineering and Medical Sciences
Columbia University
622 West 168th Street, VC12-234
New York, N.Y. 10032


General Inquiries:
Michael Bernstein

202-872-6042

Science Inquiries:
Katie Cottingham, Ph.D.

301-775-8455

Copyright © American Chemical Society

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

DOWNLOAD FULL-TEXT ARTICLE - “Electrically Conductive Chitosan/Carbon Scaffolds for Cardiac Tissue Engineering”

Related News Press

News and information

Animal study shows flexible, dissolvable silicon device promising for brain monitoring: Other applications include post-operative observation for vascular, cardiac, and orthopaedic procedures, finds Penn study May 5th, 2016

Speedy ion conduction in solid electrolytes clears road for advanced energy devices May 5th, 2016

Engineers create a better way to boil water -- with industrial, electronics applications May 5th, 2016

Clues on the path to a new lithium battery technology: Charging produces highly reactive singlet oxygen in lithium air batteries May 5th, 2016

Govt.-Legislation/Regulation/Funding/Policy

Animal study shows flexible, dissolvable silicon device promising for brain monitoring: Other applications include post-operative observation for vascular, cardiac, and orthopaedic procedures, finds Penn study May 5th, 2016

Speedy ion conduction in solid electrolytes clears road for advanced energy devices May 5th, 2016

Engineers create a better way to boil water -- with industrial, electronics applications May 5th, 2016

Clues on the path to a new lithium battery technology: Charging produces highly reactive singlet oxygen in lithium air batteries May 5th, 2016

Discoveries

Animal study shows flexible, dissolvable silicon device promising for brain monitoring: Other applications include post-operative observation for vascular, cardiac, and orthopaedic procedures, finds Penn study May 5th, 2016

Speedy ion conduction in solid electrolytes clears road for advanced energy devices May 5th, 2016

Engineers create a better way to boil water -- with industrial, electronics applications May 5th, 2016

Unique nano-capsules promise the targeted drug delivery: Russian scientists created unique nano-capsules for the targeted drug delivery May 5th, 2016

Announcements

Speedy ion conduction in solid electrolytes clears road for advanced energy devices May 5th, 2016

Engineers create a better way to boil water -- with industrial, electronics applications May 5th, 2016

Clues on the path to a new lithium battery technology: Charging produces highly reactive singlet oxygen in lithium air batteries May 5th, 2016

Unique nano-capsules promise the targeted drug delivery: Russian scientists created unique nano-capsules for the targeted drug delivery May 5th, 2016

Interviews/Book Reviews/Essays/Reports/Podcasts/Journals/White papers

Animal study shows flexible, dissolvable silicon device promising for brain monitoring: Other applications include post-operative observation for vascular, cardiac, and orthopaedic procedures, finds Penn study May 5th, 2016

Speedy ion conduction in solid electrolytes clears road for advanced energy devices May 5th, 2016

Engineers create a better way to boil water -- with industrial, electronics applications May 5th, 2016

Clues on the path to a new lithium battery technology: Charging produces highly reactive singlet oxygen in lithium air batteries May 5th, 2016

Alliances/Trade associations/Partnerships/Distributorships

Electrically Conductive Graphene Ink Enables Printing of Biosensors April 23rd, 2016

Leti Extends Collaboration with Qualcomm on CoolCubeTM 3D Integration Technology for High-Density, High-Performance ICs: Collaboration Goals Include Building an Ecosystem To Take the Chip-stacking Technology from Design to Fabrication April 13th, 2016

FEI Partners with Five Pharmaceutical Companies, the Medical Research Council and the University of Cambridge to form Cryo-EM Research Consortium April 5th, 2016

Strem Chemicals and SONA Nanotech Sign Distribution Agreement for the World’s First Gold Nanorods Synthesized without CTAB February 24th, 2016

Research partnerships

Speedy ion conduction in solid electrolytes clears road for advanced energy devices May 5th, 2016

The intermediates in a chemical reaction photographed 'red-handed' Researchers at the UPV/EHU-University of the Basque Country have for the first time succeeded in imaging all the steps in a complex organic reaction and have resolved the mechanisms that explain it May 4th, 2016

Making invisible physics visible: The Jayich Lab has created a new sensor technology that captures nanoscale images with high spatial resolution and sensitivity May 2nd, 2016

Cooling graphene-based film close to pilot-scale production April 30th, 2016

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







Car Brands
Buy website traffic