Nanotechnology Now

Our NanoNews Digest Sponsors


Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > Tiny ‘Lego’ blocks build Janus nanotubes with potential for new drugs and water purification

Abstract:
Researchers have created tiny protein tubes named after the Roman god Janus which may offer a new way to accurately channel drugs into the body's cells.

Tiny ‘Lego’ blocks build Janus nanotubes with potential for new drugs and water purification

Coventry, UK | Posted on November 14th, 2013

Using a process which they liken to molecular Lego, scientists from the University of Warwick and the University of Sydney have created what they have named ‘Janus nanotubes' - very small tubes with two distinct faces. The study is published in the journal Nature Communications.

They are named after the Roman god Janus who is usually depicted as having two faces, since he looks to the future and the past.

The Janus nanotubes have a tubular structure based on the stacking of cyclic peptides, which provide a tube with a channel of around 1nm (around one millionth of a mm) - the right size to allow small molecules and ions to pass through.

Attached to each of the cyclic peptides are two different types of polymers, which tend to de-mix and form a shell for the tube with two faces - hence the name Janus nanotubes.

The faces provide two remarkable properties - in the solid state, they could be used to make solid state membranes which can act as molecular ‘sieves' to separate liquids and gases one molecule at a time. This property is promising for applications such as water purification, water desalination and gas storage.

In a solution, they assemble in lipids bilayers, the structure that forms the membrane of cells, and they organise themselves to form pores which allow the passage of molecules of precise sizes. In this state they could be used for the development of new drug systems, by controlling the transport of small molecules or ions inside cells.

Sebastien Perrier of the University of Warwick said: "There is an extraordinary amount of activity inside the body to move the right chemicals in the right amounts both into and out of cells.

"Much of this work is done by channel proteins, for example in our nervous system where they modulate electrical signals by gating the flow of ions across the cell membrane.

"As ion channels are a key component of a wide variety of biological process, for example in cardiac, skeletal and muscle contraction, T-cell activation and pancreatic beta-cell insulin release, they are a frequent target in the search for new drugs.

"Our work has created a new type of material - nanotubes - which can be used to replace these channel processes and can be controlled with a much higher level of accuracy than natural channel proteins.

"Through a process of molecular engineering - a bit like molecular Lego - we have assembled the nanotubes from two types of building blocks - cyclic peptides and polymers.

"Janus nanotubes are a versatile platform for the design of exciting materials which have a wide range of application, from membranes - for instance for the purification of water, to therapeutic uses, for the development of new drug systems."

The study, Janus cyclic peptide-polymer nanotubes, was authored by Maarten Danial, Carmen My-Nhi Tran, Philip G. Young, Sebastien Perrier, & Katrina A. Jolliffe

####

For more information, please click here

Contacts:
Anna Blackaby
International Press Officer
Tel: 44 024 7657 5910
Mob: 44 07785 433155

or
Kelly Parkes-Harrison
Senior Press and Communications Manager
Tel: 44 024 7615 0868
Mob: 44 07824 540863


Sebastien Perrier
44 07528422246

Copyright © University of Warwick

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

GLOBALFOUNDRIES to Expand Presence in China with 300mm Fab in Chongqing: Company plans new manufacturing facility and additional design capabilities to serve customers in China May 31st, 2016

Nanobiotix establishes promising preclinical proof-of-concept in Immuno Oncology May 31st, 2016

UK NANOSAFETY GROUP publishes 2nd Edition of guidance to support safe working with nanomaterials May 30th, 2016

Fast, stretchy circuits could yield new wave of wearable electronics May 30th, 2016

Nanotubes/Buckyballs/Fullerenes

Programmable materials find strength in molecular repetition May 23rd, 2016

Nanotubes are beacons in cancer-imaging technique: Rice University researchers use spectral triangulation to pinpoint location of tumors May 21st, 2016

Unveiling the electron's motion in a carbon nanocoil: Development of a precise resistivity measurement system for quasi-one-dimensional nanomaterials using a focused ion beam May 16th, 2016

New research shows how silver could be the key to gold-standard flexible gadgets: Silver nanowires are an ideal material for current and future flexible touch-screen technologies May 13th, 2016

Nanomedicine

Nanobiotix establishes promising preclinical proof-of-concept in Immuno Oncology May 31st, 2016

Automating DNA origami opens door to many new uses: Like 3-D printing did for larger objects, method makes it easy to build nanoparticles out of DNA May 30th, 2016

Simple attraction: Researchers control protein release from nanoparticles without encapsulation: U of T Engineering discovery stands to improve reliability and fabrication process for treatments to conditions such as spinal cord damage and stroke May 28th, 2016

Scientists illuminate a hidden regulator in gene transcription: New super-resolution technique visualizes important role of short-lived enzyme clusters May 27th, 2016

Discoveries

Fast, stretchy circuits could yield new wave of wearable electronics May 30th, 2016

Automating DNA origami opens door to many new uses: Like 3-D printing did for larger objects, method makes it easy to build nanoparticles out of DNA May 30th, 2016

Simple attraction: Researchers control protein release from nanoparticles without encapsulation: U of T Engineering discovery stands to improve reliability and fabrication process for treatments to conditions such as spinal cord damage and stroke May 28th, 2016

Scientists illuminate a hidden regulator in gene transcription: New super-resolution technique visualizes important role of short-lived enzyme clusters May 27th, 2016

Announcements

GLOBALFOUNDRIES to Expand Presence in China with 300mm Fab in Chongqing: Company plans new manufacturing facility and additional design capabilities to serve customers in China May 31st, 2016

Nanobiotix establishes promising preclinical proof-of-concept in Immuno Oncology May 31st, 2016

UK NANOSAFETY GROUP publishes 2nd Edition of guidance to support safe working with nanomaterials May 30th, 2016

Fast, stretchy circuits could yield new wave of wearable electronics May 30th, 2016

Interviews/Book Reviews/Essays/Reports/Podcasts/Journals/White papers

UK NANOSAFETY GROUP publishes 2nd Edition of guidance to support safe working with nanomaterials May 30th, 2016

Fast, stretchy circuits could yield new wave of wearable electronics May 30th, 2016

Automating DNA origami opens door to many new uses: Like 3-D printing did for larger objects, method makes it easy to build nanoparticles out of DNA May 30th, 2016

Simple attraction: Researchers control protein release from nanoparticles without encapsulation: U of T Engineering discovery stands to improve reliability and fabrication process for treatments to conditions such as spinal cord damage and stroke May 28th, 2016

Water

Mille-feuille-filter removes viruses from water May 19th, 2016

First single-enzyme method to produce quantum dots revealed: Biological manufacturing process, pioneered by three Lehigh University engineers, produces equivalent quantum dots to those made chemically--but in a much greener, cheaper way May 9th, 2016

Understanding tiny droplets can make for better weather forecasts: Climate change models also benefit from understanding fundamental thermodynamics of water droplets May 6th, 2016

Engineers create a better way to boil water -- with industrial, electronics applications May 5th, 2016

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







Car Brands
Buy website traffic