Nanotechnology Now

Our NanoNews Digest Sponsors



Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > Tiny ‘Lego’ blocks build Janus nanotubes with potential for new drugs and water purification

Abstract:
Researchers have created tiny protein tubes named after the Roman god Janus which may offer a new way to accurately channel drugs into the body's cells.

Tiny ‘Lego’ blocks build Janus nanotubes with potential for new drugs and water purification

Coventry, UK | Posted on November 14th, 2013

Using a process which they liken to molecular Lego, scientists from the University of Warwick and the University of Sydney have created what they have named ‘Janus nanotubes' - very small tubes with two distinct faces. The study is published in the journal Nature Communications.

They are named after the Roman god Janus who is usually depicted as having two faces, since he looks to the future and the past.

The Janus nanotubes have a tubular structure based on the stacking of cyclic peptides, which provide a tube with a channel of around 1nm (around one millionth of a mm) - the right size to allow small molecules and ions to pass through.

Attached to each of the cyclic peptides are two different types of polymers, which tend to de-mix and form a shell for the tube with two faces - hence the name Janus nanotubes.

The faces provide two remarkable properties - in the solid state, they could be used to make solid state membranes which can act as molecular ‘sieves' to separate liquids and gases one molecule at a time. This property is promising for applications such as water purification, water desalination and gas storage.

In a solution, they assemble in lipids bilayers, the structure that forms the membrane of cells, and they organise themselves to form pores which allow the passage of molecules of precise sizes. In this state they could be used for the development of new drug systems, by controlling the transport of small molecules or ions inside cells.

Sebastien Perrier of the University of Warwick said: "There is an extraordinary amount of activity inside the body to move the right chemicals in the right amounts both into and out of cells.

"Much of this work is done by channel proteins, for example in our nervous system where they modulate electrical signals by gating the flow of ions across the cell membrane.

"As ion channels are a key component of a wide variety of biological process, for example in cardiac, skeletal and muscle contraction, T-cell activation and pancreatic beta-cell insulin release, they are a frequent target in the search for new drugs.

"Our work has created a new type of material - nanotubes - which can be used to replace these channel processes and can be controlled with a much higher level of accuracy than natural channel proteins.

"Through a process of molecular engineering - a bit like molecular Lego - we have assembled the nanotubes from two types of building blocks - cyclic peptides and polymers.

"Janus nanotubes are a versatile platform for the design of exciting materials which have a wide range of application, from membranes - for instance for the purification of water, to therapeutic uses, for the development of new drug systems."

The study, Janus cyclic peptide-polymer nanotubes, was authored by Maarten Danial, Carmen My-Nhi Tran, Philip G. Young, Sebastien Perrier, & Katrina A. Jolliffe

####

For more information, please click here

Contacts:
Anna Blackaby
International Press Officer
Tel: 44 024 7657 5910
Mob: 44 07785 433155

or
Kelly Parkes-Harrison
Senior Press and Communications Manager
Tel: 44 024 7615 0868
Mob: 44 07824 540863


Sebastien Perrier
44 07528422246

Copyright © University of Warwick

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Creation of 'Rocker' protein opens way for new smart molecules in medicine, other fields December 18th, 2014

How does enzymatic pretreatment affect the nanostructure and reaction space of lignocellulosic biomass? December 18th, 2014

Silicon Valley-Based Foresight Valuation Launches STR-IP™, a New Initiative for Startups to Discover the Value of Their Intellectual Property December 18th, 2014

Iranian Scientists Use Nanotechnology to Increase Power, Energy of Supercapacitors December 18th, 2014

Nanotubes/Buckyballs

A sponge-like molecular cage for purification of fullerenes December 15th, 2014

'Trojan horse' proteins used to target hard-to-reach cancers: Scientists at Brunel University London have found a way of targeting hard-to-reach cancers and degenerative diseases using nanoparticles, but without causing the damaging side effects the treatment normally brings December 11th, 2014

Detecting gases wirelessly and cheaply: New sensor can transmit information on hazardous chemicals or food spoilage to a smartphone December 8th, 2014

Green meets nano: Scientists at TU Darmstadt create multifunctional nanotubes using nontoxic materials December 3rd, 2014

Nanomedicine

Creation of 'Rocker' protein opens way for new smart molecules in medicine, other fields December 18th, 2014

Iranian Researchers Produce Electrical Pieces Usable in Human Body December 18th, 2014

Unraveling the light of fireflies December 17th, 2014

First Home-Made Edible Herbal Nanodrug Presented to Pharmacies across Iran December 17th, 2014

Discoveries

Creation of 'Rocker' protein opens way for new smart molecules in medicine, other fields December 18th, 2014

How does enzymatic pretreatment affect the nanostructure and reaction space of lignocellulosic biomass? December 18th, 2014

Iranian Scientists Use Nanotechnology to Increase Power, Energy of Supercapacitors December 18th, 2014

Iranian Researchers Produce Electrical Pieces Usable in Human Body December 18th, 2014

Announcements

Creation of 'Rocker' protein opens way for new smart molecules in medicine, other fields December 18th, 2014

How does enzymatic pretreatment affect the nanostructure and reaction space of lignocellulosic biomass? December 18th, 2014

Silicon Valley-Based Foresight Valuation Launches STR-IP™, a New Initiative for Startups to Discover the Value of Their Intellectual Property December 18th, 2014

Iranian Scientists Use Nanotechnology to Increase Power, Energy of Supercapacitors December 18th, 2014

Interviews/Book Reviews/Essays/Reports/Podcasts/Journals/White papers

Creation of 'Rocker' protein opens way for new smart molecules in medicine, other fields December 18th, 2014

How does enzymatic pretreatment affect the nanostructure and reaction space of lignocellulosic biomass? December 18th, 2014

Iranian Scientists Use Nanotechnology to Increase Power, Energy of Supercapacitors December 18th, 2014

Iranian Researchers Produce Electrical Pieces Usable in Human Body December 18th, 2014

Water

Unraveling the light of fireflies December 17th, 2014

Biomimetic dew harvesters: Understanding how a desert beetle harvests water from dew could improve drinking water collection in dew condensers December 8th, 2014

Iranian Scientists Refine Wastewater of Nuclear Power Plants Using Nanoparticles December 1st, 2014

Iranian Experts Clean Uranium-Contaminated Water by Nano-Particles November 23rd, 2014

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More










ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE