Nanotechnology Now







Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > 'Molecular Velcro' may lead to cost-effective alternatives to natural antibodies: Berkeley Lab researchers take cues from nature in designing a programmable nanomaterial for biosensing

Long organic molecules called peptoids self-assemble into a molecular film on the surface of a water solution. As this film gets folded into a nanosheet, segments of the peptoid get pushed out into loops, which eventually decorate the surface of the nanosheet.

Credit: Berkeley Lab
Long organic molecules called peptoids self-assemble into a molecular film on the surface of a water solution. As this film gets folded into a nanosheet, segments of the peptoid get pushed out into loops, which eventually decorate the surface of the nanosheet.

Credit: Berkeley Lab

Abstract:
Taking inspiration from the human immune system, researchers at the U.S. Department of Energy's Lawrence Berkeley National Laboratory (Berkeley Lab) have created a new material that can be programmed to identify an endless variety of molecules. The new material resembles tiny sheets of Velcro, each just one-hundred nanometers across. But instead of securing your sneakers, this molecular Velcro mimics the way natural antibodies recognize viruses and toxins, and could lead to a new class of biosensors.

'Molecular Velcro' may lead to cost-effective alternatives to natural antibodies: Berkeley Lab researchers take cues from nature in designing a programmable nanomaterial for biosensing

Berkeley, CA | Posted on October 30th, 2013

"Antibodies have a really effective architectural design: a structural scaffold that pretty much stays the same, whether it's for snake venom or the common cold, and endlessly variable functional loops that bind foreign invaders," says Ron Zuckermann, a senior scientist at Berkeley Lab's Molecular Foundry. "We've mimicked that here, with a two-dimensional nanosheet scaffold covered with little functional loops like Velcro."

Zuckermann, Director of the Molecular Foundry's Biological Nanostructures Facility, is corresponding author on a paper reporting these results in ACS Nano, titled "Antibody-Mimetic Peptoid Nanosheets for Molecular Recognition." Coauthoring the paper are Gloria K. Olivier, Andrew Cho, Babak Sanii, Michael D. Connolly, and Helen Tran.

Zuckermann's nanosheet scaffolds are self-assembled from peptoids - synthetic, bio-inspired polymers capable of folding into protein-like architectures. Like beads on a string, each peptoid molecule is a long chain of small molecular units arranged in a specific pattern. In earlier work, Zuckermann showed how certain simple peptoids can fold themselves into nanosheets just a few nanometers thick but up to one-hundred micrometers across - dimensions equivalent to a one-millimeter-thick plastic sheet the size of a football field.

"The reason that nanosheets form is because there's a code for it programmed directly into the peptoids," says Zuckermann. "In this case it's admittedly a pretty rudimentary program, but it shows how if you bring in just a little bit of sequence information: Boom! You can make a nanosheet."

To create functional loops on the nanosheets, the researchers insert short molecular segments into nanosheet-forming peptoid polymers. As the peptoids knit themselves together into sheets, the inserted segments are excluded from the fold, pushed out instead into loops upon the nanosheet surface. The functional loops can be programmed to selectively bind certain enzymes or inorganic materials, which makes the new material promising for chemical sensing and catalysis.

"The advantage here is that we're able to make these materials in very high yield," says Gloria Olivier, a postdoctoral researcher and lead author on the paper. "We're borrowing this idea of stringing together a particular sequence of monomers, which Nature uses to build 3D protein structures, and applying it to the world of non-natural materials, to create a really useful material that can assemble itself."

The researchers demonstrated the flexibility of their method by creating nanosheets with loops of varying composition, length, and density; they made nanosheets that can pick specific enzymes out of a solution, causing chemical changes that can be detected with standard techniques, and others that bind selectively to gold metal, seeding the growth of gold nanoparticles and films.

"Peptoids can withstand much harsher conditions than peptides, their counterpart in nature," says Olivier. "So if you wanted to build a diagnostic device that can be taken outside of a laboratory, or a device that can screen for biomarkers in the presence of a mixture of proteins like proteases, peptoids are an excellent choice."

Looking beyond the exciting applications, Zuckermann points out that this work represents an important step toward extending the rules of protein folding to the world of synthetic materials.

Says Zuckermann, "That's kind of what my whole research program here is about: learning from the richness of chemical sequence information found in biology to create new types of advanced synthetic materials. We're really just starting to scratch the surface."

###

This research was funded by the DOE Office of Science and the Defense Threat Reduction Agency. The work was conducted at the Molecular Foundry with support from the Advanced Light Source, and at the Advanced Photon Source at Argonne National Laboratory.

####

About DOE/Lawrence Berkeley National Laboratory
Lawrence Berkeley National Laboratory addresses the world's most urgent scientific challenges by advancing sustainable energy, protecting human health, creating new materials, and revealing the origin and fate of the universe. Founded in 1931, Berkeley Lab's scientific expertise has been recognized with 13 Nobel prizes. The University of California manages Berkeley Lab for the U.S. Department of Energy's Office of Science. For more, visit www.lbl.gov.

The Molecular Foundry is one of five DOE Nanoscale Science Research Centers (NSRCs), national user facilities for interdisciplinary research at the nanoscale, supported by the DOE Office of Science. Together the NSRCs comprise a suite of complementary facilities that provide researchers with state-of-the-art capabilities to fabricate, process, characterize and model nanoscale materials, and constitute the largest infrastructure investment of the National Nanotechnology Initiative. The NSRCs are located at DOE's Argonne, Brookhaven, Lawrence Berkeley, Oak Ridge and Sandia and Los Alamos National Laboratories. For more information about the DOE NSRCs, please visit science.energy.gov

The DOE Office of Science is the single largest supporter of basic research in the physical sciences in the United States and is working to address some of the most pressing challenges of our time. For more information, please visit science.energy.gov.

For more information, please click here

Contacts:
Alison Hatt

510-486-7154

Copyright © DOE/Lawrence Berkeley National Laboratory

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

Download article - "Antibody-Mimetic Peptoid Nanosheets for Molecular Recognition." Gloria K. Olivier, Andrew Cho, Babak Sanii, Michael D. Connolly, Helen Tran, and Ronald N. Zuckermann. ACS Nano, 7, 9276-9386, (2013):

For more about this research, listen to Episode 75 of the ACS Nano podcast:

For more about Ron Zuckermann's research and the Molecular Foundry, visit:

Related News Press

News and information

A first glimpse inside a macroscopic quantum state March 28th, 2015

DFG to Establish One Clinical Research Unit and Five Research Units: New Projects to Investigate Complications in Pregnancy, Particle Physics, Nanoparticles, Implants and Transport Planning / Approximately 13 Million Euros in Funding for an Initial Three-Year Period March 28th, 2015

Chemists make new silicon-based nanomaterials March 27th, 2015

UT Dallas engineers twist nanofibers to create structures tougher than bulletproof vests March 27th, 2015

State-of-the-art online system unveiled to pinpoint metrology software accuracy March 27th, 2015

Laboratories

Using magnetic fields to understand high-temperature superconductivity: Los Alamos explores experimental path to potential 'next theory of superconductivity' March 27th, 2015

ORNL-led team demonstrates desalination with nanoporous graphene membrane March 25th, 2015

Los Alamos Offers New Insights Into Radiation Damage Evolution: TUnderstanding defects in materials aids in performance predictions March 18th, 2015

Synthetic Biology

Democratizing synthetic biology: New method makes research cheaper, faster, and more accessible March 3rd, 2015

New tool could help reshape the limits of synthetic biology: The 'telomerator' reshapes synthetic yeast chromosome into more flexible, realistic form, redefining what geneticists can build November 3rd, 2014

Tiny carbon nanotube pores make big impact October 29th, 2014

Smallest world record has 'endless possibilities' for bio-nanotechnology October 8th, 2014

Govt.-Legislation/Regulation/Funding/Policy

UT Dallas engineers twist nanofibers to create structures tougher than bulletproof vests March 27th, 2015

Novel nanoparticle therapy promotes wound healing March 27th, 2015

Designer's toolkit for dynamic DNA nanomachines: Arm-waving nanorobot signals new flexibility in DNA origami March 27th, 2015

Using magnetic fields to understand high-temperature superconductivity: Los Alamos explores experimental path to potential 'next theory of superconductivity' March 27th, 2015

Sensors

UW scientists build a nanolaser using a single atomic sheet March 24th, 2015

Iranian Researchers Present Model to Determine Dynamic Behavior of Nanostructures March 24th, 2015

Nanodevice Invented in Iran to Detect Hydrogen Sulfide in Oil, Gas Industry March 20th, 2015

LamdaGen Corporation Launches Taiwan Diagnostic Subsidiary March 19th, 2015

Discoveries

A first glimpse inside a macroscopic quantum state March 28th, 2015

UT Dallas engineers twist nanofibers to create structures tougher than bulletproof vests March 27th, 2015

Novel nanoparticle therapy promotes wound healing March 27th, 2015

Designer's toolkit for dynamic DNA nanomachines: Arm-waving nanorobot signals new flexibility in DNA origami March 27th, 2015

Materials/Metamaterials

DFG to Establish One Clinical Research Unit and Five Research Units: New Projects to Investigate Complications in Pregnancy, Particle Physics, Nanoparticles, Implants and Transport Planning / Approximately 13 Million Euros in Funding for an Initial Three-Year Period March 28th, 2015

Chemists make new silicon-based nanomaterials March 27th, 2015

UT Dallas engineers twist nanofibers to create structures tougher than bulletproof vests March 27th, 2015

Using magnetic fields to understand high-temperature superconductivity: Los Alamos explores experimental path to potential 'next theory of superconductivity' March 27th, 2015

Announcements

A first glimpse inside a macroscopic quantum state March 28th, 2015

DFG to Establish One Clinical Research Unit and Five Research Units: New Projects to Investigate Complications in Pregnancy, Particle Physics, Nanoparticles, Implants and Transport Planning / Approximately 13 Million Euros in Funding for an Initial Three-Year Period March 28th, 2015

Designer's toolkit for dynamic DNA nanomachines: Arm-waving nanorobot signals new flexibility in DNA origami March 27th, 2015

Using magnetic fields to understand high-temperature superconductivity: Los Alamos explores experimental path to potential 'next theory of superconductivity' March 27th, 2015

Interviews/Book Reviews/Essays/Reports/Podcasts/Journals/White papers

A first glimpse inside a macroscopic quantum state March 28th, 2015

Chemists make new silicon-based nanomaterials March 27th, 2015

UT Dallas engineers twist nanofibers to create structures tougher than bulletproof vests March 27th, 2015

Novel nanoparticle therapy promotes wound healing March 27th, 2015

Military

UT Dallas engineers twist nanofibers to create structures tougher than bulletproof vests March 27th, 2015

Novel nanoparticle therapy promotes wound healing March 27th, 2015

Thousands of atoms entangled with a single photon: Result could make atomic clocks more accurate March 26th, 2015

Carbon nanotube fibers make superior links to brain: Rice University invention provides two-way communication with neurons March 25th, 2015

Nanobiotechnology

Designer's toolkit for dynamic DNA nanomachines: Arm-waving nanorobot signals new flexibility in DNA origami March 27th, 2015

Dolomite’s microfluidics technology ideal for B cell encapsulation March 24th, 2015

Tiny bio-robot is a germ suited-up with graphene quantum dots March 24th, 2015

TGAC's take on the first portable DNA sequencing 'laboratory': First remote laboratory allows researchers to conduct real-time anaylsis March 19th, 2015

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More










ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2015 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE