Nanotechnology Now

Our NanoNews Digest Sponsors


Heifer International

Wikipedia Affiliate Button

Home > Press > A mimic of ‘good cholesterol’ could someday treat cardiovascular and other diseases

Artery-clogging “bad cholesterol” could one day be fought with a new type of “good cholesterol” made in the lab.
Credit: iStock/Thinkstock
Artery-clogging “bad cholesterol” could one day be fought with a new type of “good cholesterol” made in the lab.

Credit: iStock/Thinkstock

Abstract:
A new type of "good cholesterol," made in the lab, could one day deliver drugs to where they are needed in the body to treat disease or be used in medical imaging, according to scientists. Their report on the high-density lipoprotein (HDL) mimic, which is easy to make in large amounts, appears in the journal ACS Nano.

A mimic of ‘good cholesterol’ could someday treat cardiovascular and other diseases

Washington, DC | Posted on October 30th, 2013

Zahi A. Fayad, Robert Langer, YongTae (Tony) Kim, Francois Fay, Willem Mulder and colleagues explain that HDL is a natural nanoparticle that carries cholesterol throughout the body. Because it acts like a scavenger, collecting cholesterol and taking it to the liver for breakdown, HDL has emerged from being simply a marker for cardiovascular disease — the number one killer of men and women in America — to being a therapeutic agent. Clinical trials are testing its potential to combat atherosclerosis, the build-up of plaques in blood vessels that can lead to heart attacks or strokes. Scientists are also exploring new ways to use it for drug delivery. But HDL is complex and comes in many varieties. It takes several labor-intensive steps to get a uniform collection of these particles with current methods, which aren't easily scaled up for clinical applications. That's why Fayad and Langer's groups devised a new and improved method for making HDL-like particles.

The scientists showed that microfluidics — the same technology that enabled the invention of inkjet printers — allowed them to make material called µHDL that looks and acts like HDL in a single, rapid step. Not only does this material offer a possible, easy new way to treat cardiovascular disease, but the researchers also attached drug compounds, as well as dyes and nanocrystals used in medical imaging (such as those used for MRIs and CT scans), to the particles.

The authors acknowledge funding from National Heart, Lung, and Blood Institute, the National Institutes of Health, the National Cancer Institute, the Prostate Cancer Foundation and the American Heart Association.

####

About American Chemical Society
The American Chemical Society is a nonprofit organization chartered by the U.S. Congress. With more than 163,000 members, ACS is the world’s largest scientific society and a global leader in providing access to chemistry-related research through its multiple databases, peer-reviewed journals and scientific conferences. Its main offices are in Washington, D.C., and Columbus, Ohio.

For more information, please click here

Contacts:
Zahi A. Fayad, Ph.D.
Translational and Molecular Imaging Institute
Icahn School of Medicine at Mount Sinai
New York City, N.Y. 10029

or
Robert Langer, Sc.D.
David H. Koch Institute for Integrative Cancer Research
Massachusetts Institute of Technology
Cambridge, Mass. 02139


General Inquiries: Michael Bernstein

202-872-6042

Science Inquiries: Katie Cottingham, Ph.D.

301-775-8455

Copyright © American Chemical Society

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

DOWNLOAD FULL-TEXT ARTICLE - “Single Step Reconstitution of Multifunctional High-Density Lipoprotein-Derived Nanomaterials Using Microfluidics”

Related News Press

Imaging

New approach to determining how atoms are arranged in materials August 25th, 2016

News and information

Unraveling the crystal structure of a -70° Celsius superconductor, a world first: Significant advancement in the realization of room-temperature superconductors August 25th, 2016

Stretchy supercapacitors power wearable electronics August 25th, 2016

AIM Photonics Announces Release of Process Design Kit (PDK) for Integrated Silicon Photonics Design August 25th, 2016

Semblant to Present at China Mobile Manufacturing Forum 2016 August 25th, 2016

Microfluidics/Nanofluidics

W.M. Keck Foundation awards Cal State LA a $375,000 research and education grant August 4th, 2016

Researchers invent 'smart' thread that collects diagnostic data when sutured into tissue: Advances could pave way for new generation of implantable and wearable diagnostics July 18th, 2016

Droplets finally all the same size -- in a nanodroplet library June 20th, 2016

NanoLabNL boosts quality of research facilities as Dutch Toekomstfonds invests firmly June 10th, 2016

Govt.-Legislation/Regulation/Funding/Policy

Analog DNA circuit does math in a test tube: DNA computers could one day be programmed to diagnose and treat disease August 25th, 2016

New approach to determining how atoms are arranged in materials August 25th, 2016

Johns Hopkins scientists track metabolic pathways to find drug combination for pancreatic cancer August 25th, 2016

New electrical energy storage material shows its power: Nanomaterial combines attributes of both batteries and supercapacitors August 25th, 2016

Nanomedicine

Nanofiber scaffolds demonstrate new features in the behavior of stem and cancer cells August 25th, 2016

Johns Hopkins scientists track metabolic pathways to find drug combination for pancreatic cancer August 25th, 2016

50 years after the release of the film 'Fantastic Voyage,' science upstages fiction: Science upstages fiction with nanorobotic agents designed to travel in the human body to treat cancer August 25th, 2016

Tunneling nanotubes between neurons enable the spread of Parkinson's disease via lysosomes August 24th, 2016

Discoveries

Unraveling the crystal structure of a -70° Celsius superconductor, a world first: Significant advancement in the realization of room-temperature superconductors August 25th, 2016

Stretchy supercapacitors power wearable electronics August 25th, 2016

Johns Hopkins scientists track metabolic pathways to find drug combination for pancreatic cancer August 25th, 2016

New electrical energy storage material shows its power: Nanomaterial combines attributes of both batteries and supercapacitors August 25th, 2016

Announcements

Analog DNA circuit does math in a test tube: DNA computers could one day be programmed to diagnose and treat disease August 25th, 2016

Silicon nanoparticles trained to juggle light: Research findings prove the capabilities of silicon nanoparticles for flexible data processing in optical communication systems August 25th, 2016

Johns Hopkins scientists track metabolic pathways to find drug combination for pancreatic cancer August 25th, 2016

New electrical energy storage material shows its power: Nanomaterial combines attributes of both batteries and supercapacitors August 25th, 2016

Interviews/Book Reviews/Essays/Reports/Podcasts/Journals/White papers

Analog DNA circuit does math in a test tube: DNA computers could one day be programmed to diagnose and treat disease August 25th, 2016

Silicon nanoparticles trained to juggle light: Research findings prove the capabilities of silicon nanoparticles for flexible data processing in optical communication systems August 25th, 2016

New approach to determining how atoms are arranged in materials August 25th, 2016

New electrical energy storage material shows its power: Nanomaterial combines attributes of both batteries and supercapacitors August 25th, 2016

Grants/Awards/Scholarships/Gifts/Contests/Honors/Records

New electrical energy storage material shows its power: Nanomaterial combines attributes of both batteries and supercapacitors August 25th, 2016

Light and matter merge in quantum coupling: Rice University physicists probe photon-electron interactions in vacuum cavity experiments August 24th, 2016

New flexible material can make any window 'smart' August 23rd, 2016

Researchers watch catalysts at work August 19th, 2016

Alliances/Trade associations/Partnerships/Distributorships

Thomas Swan and NGI announce unique partnership July 28th, 2016

Starpharma initiates new DEP™ drug delivery program with AstraZeneca July 27th, 2016

XEI Scientific Partners with Electron Microscopy Sciences to Promote and Sell its Products in North and South America July 25th, 2016

Leti and Korea Institute of Science and Technology to Explore Collaboration on Advanced Technologies for Digital Era July 14th, 2016

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







Car Brands
Buy website traffic