Nanotechnology Now

Our NanoNews Digest Sponsors



Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > New “click” reaction: chemistry applicable to living organisms

vignette
vignette

Abstract:
Two CEA-Ibitec-S teams have developed a new "click" chemistry process for specific assembly of two components without modifying their properties or the medium in which the reaction takes place. The process can be carried out under any conditions, whatever the characteristics of the medium. This new click reaction can be used to connect two components (molecules, proteins, nanoparticles, etc.) in biological media as complex as human blood. These results have been published on the Angewandte Chemie website.

New “click” reaction: chemistry applicable to living organisms

Paris, France | Posted on October 16th, 2013

Using an approach based on high-speed screening of thousands of reagent combinations, two Ibitec-S teams have discovered a new reaction meeting all the criteria of what is known as click chemistry:

effective under any reaction conditions;
applicable to biological media;
selective (the reaction must not interfere with satisfactory functioning of the medium).

The reaction developed by the researchers can assemble two components specifically, without altering their properties or their medium. This is accomplished by attaching a particular chemical group to each of the components (two proteins, for example): a dipole called sydnone (heterocyclic chemical group bearing a positive and a negative charge) to one component, an alkyne group (with a triple chemical bond, see figure 1) to the other. These two groups act to "click" the two components together when the click reaction catalyst (copper) is injected into the medium.

Applications

Although chemists have thousands of chemical reactions they can use to build increasingly sophisticated molecular edifices, only a few of these reactions can be used by biologists. Biological media have characteristics (temperature, water, osmotic pressure, etc.) that make it impossible to transpose most chemical reactions to them, even reactions that are fully mastered in vitro. The requirements for a reaction applicable to biological media are particularly restrictive: aqueous medium, ambient temperature, presence of many functional groups (thiols, amines, etc.). Consequently, very few reactions can be used with biological materials.

This reaction can be used to connect two components in biological media as complex as human blood. The potential applications of this new click reaction extend from medicinal chemistry (e.g. attachment of drugs to therapeutic antibodies) to biotechnology (e.g. tracers for medical imaging).


Full bibliographic informationReferences:
Kolodych, S., Rasolofonjatovo, E., Chaumontet, M., Nevers, M.-C., Créminon, C. and Taran, F. (2013), "Discovery of Chemoselective and Biocompatible Reactions Using a High-Throughput Immunoassay Screening". Angew. Chem. Int. Ed.. doi: 10.1002/anie.201305645

Procédé de fabrication de pyrazoles, nouveaux pyrazoles et applications. F. Taran, M. Chaumontet, S. Kolodych, E. Rasolofonjatovo. Fr. Demande N°1351146 (11/02/2013).

####

About Commissariat a l'Energie Atomique (CEA)
The French Atomic Energy Commission (CEA) is a key player in research, development and innovation in the fields of energy, defense, information technologies, communication and health. Ever since it was created in 1945, it has successfully responded to major scientific challenges in many fields, including the French nuclear power generation program, nuclear deterrence, micro- and nanotechnologies, astrophysics, medical imaging, toxicology, biotechnologies, etc.

For more information, please click here

Contacts:
Carolyn Anderson
+33 1-64-50-20-11

Copyright © AlphaGalileo

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Oregon researchers glimpse pathway of sunlight to electricity: Collaboration with Lund University uses modified UO spectroscopy equipment to study 'maze' of connections in photoactive quantum dots December 19th, 2014

Instant-start computers possible with new breakthrough December 19th, 2014

Aculon Hires New Business Development Director December 19th, 2014

Iranian Scientists Use Nanotechnology to Increase Power, Energy of Supercapacitors December 18th, 2014

Laboratories

Switching to spintronics: Berkeley Lab reports on electric field switching of ferromagnetism at room temp December 17th, 2014

ORNL microscopy pencils patterns in polymers at the nanoscale December 17th, 2014

Imaging

Switching to spintronics: Berkeley Lab reports on electric field switching of ferromagnetism at room temp December 17th, 2014

ORNL microscopy pencils patterns in polymers at the nanoscale December 17th, 2014

Unraveling the light of fireflies December 17th, 2014

Govt.-Legislation/Regulation/Funding/Policy

Oregon researchers glimpse pathway of sunlight to electricity: Collaboration with Lund University uses modified UO spectroscopy equipment to study 'maze' of connections in photoactive quantum dots December 19th, 2014

Zenosense, Inc. - Hospital Collaboration - 400 Person Lung Cancer Detection Trial December 17th, 2014

SUNY Poly NanoCollege Faculty Member Selected as American Physical Society Fellow: SUNY Poly Associate Professor of Nanoscience Dr. Vincent LaBella Recognized for Significant Technological Innovations that Enable Interactive Learning December 17th, 2014

Switching to spintronics: Berkeley Lab reports on electric field switching of ferromagnetism at room temp December 17th, 2014

Nanomedicine

Creation of 'Rocker' protein opens way for new smart molecules in medicine, other fields December 18th, 2014

Iranian Researchers Produce Electrical Pieces Usable in Human Body December 18th, 2014

Zenosense, Inc. - Hospital Collaboration - 400 Person Lung Cancer Detection Trial December 17th, 2014

Unraveling the light of fireflies December 17th, 2014

Discoveries

Oregon researchers glimpse pathway of sunlight to electricity: Collaboration with Lund University uses modified UO spectroscopy equipment to study 'maze' of connections in photoactive quantum dots December 19th, 2014

Instant-start computers possible with new breakthrough December 19th, 2014

Creation of 'Rocker' protein opens way for new smart molecules in medicine, other fields December 18th, 2014

Iranian Scientists Use Nanotechnology to Increase Power, Energy of Supercapacitors December 18th, 2014

Announcements

Oregon researchers glimpse pathway of sunlight to electricity: Collaboration with Lund University uses modified UO spectroscopy equipment to study 'maze' of connections in photoactive quantum dots December 19th, 2014

Instant-start computers possible with new breakthrough December 19th, 2014

Aculon Hires New Business Development Director December 19th, 2014

Iranian Scientists Use Nanotechnology to Increase Power, Energy of Supercapacitors December 18th, 2014

Interviews/Book Reviews/Essays/Reports/Podcasts/Journals/White papers

Oregon researchers glimpse pathway of sunlight to electricity: Collaboration with Lund University uses modified UO spectroscopy equipment to study 'maze' of connections in photoactive quantum dots December 19th, 2014

Instant-start computers possible with new breakthrough December 19th, 2014

How does enzymatic pretreatment affect the nanostructure and reaction space of lignocellulosic biomass? December 18th, 2014

Iranian Scientists Use Nanotechnology to Increase Power, Energy of Supercapacitors December 18th, 2014

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More










ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE