Nanotechnology Now

Our NanoNews Digest Sponsors


Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > New “click” reaction: chemistry applicable to living organisms

vignette
vignette

Abstract:
Two CEA-Ibitec-S teams have developed a new "click" chemistry process for specific assembly of two components without modifying their properties or the medium in which the reaction takes place. The process can be carried out under any conditions, whatever the characteristics of the medium. This new click reaction can be used to connect two components (molecules, proteins, nanoparticles, etc.) in biological media as complex as human blood. These results have been published on the Angewandte Chemie website.

New “click” reaction: chemistry applicable to living organisms

Paris, France | Posted on October 16th, 2013

Using an approach based on high-speed screening of thousands of reagent combinations, two Ibitec-S teams have discovered a new reaction meeting all the criteria of what is known as click chemistry:

effective under any reaction conditions;
applicable to biological media;
selective (the reaction must not interfere with satisfactory functioning of the medium).

The reaction developed by the researchers can assemble two components specifically, without altering their properties or their medium. This is accomplished by attaching a particular chemical group to each of the components (two proteins, for example): a dipole called sydnone (heterocyclic chemical group bearing a positive and a negative charge) to one component, an alkyne group (with a triple chemical bond, see figure 1) to the other. These two groups act to "click" the two components together when the click reaction catalyst (copper) is injected into the medium.

Applications

Although chemists have thousands of chemical reactions they can use to build increasingly sophisticated molecular edifices, only a few of these reactions can be used by biologists. Biological media have characteristics (temperature, water, osmotic pressure, etc.) that make it impossible to transpose most chemical reactions to them, even reactions that are fully mastered in vitro. The requirements for a reaction applicable to biological media are particularly restrictive: aqueous medium, ambient temperature, presence of many functional groups (thiols, amines, etc.). Consequently, very few reactions can be used with biological materials.

This reaction can be used to connect two components in biological media as complex as human blood. The potential applications of this new click reaction extend from medicinal chemistry (e.g. attachment of drugs to therapeutic antibodies) to biotechnology (e.g. tracers for medical imaging).


Full bibliographic informationReferences:
Kolodych, S., Rasolofonjatovo, E., Chaumontet, M., Nevers, M.-C., Créminon, C. and Taran, F. (2013), "Discovery of Chemoselective and Biocompatible Reactions Using a High-Throughput Immunoassay Screening". Angew. Chem. Int. Ed.. doi: 10.1002/anie.201305645

Procédé de fabrication de pyrazoles, nouveaux pyrazoles et applications. F. Taran, M. Chaumontet, S. Kolodych, E. Rasolofonjatovo. Fr. Demande N°1351146 (11/02/2013).

####

About Commissariat a l'Energie Atomique (CEA)
The French Atomic Energy Commission (CEA) is a key player in research, development and innovation in the fields of energy, defense, information technologies, communication and health. Ever since it was created in 1945, it has successfully responded to major scientific challenges in many fields, including the French nuclear power generation program, nuclear deterrence, micro- and nanotechnologies, astrophysics, medical imaging, toxicology, biotechnologies, etc.

For more information, please click here

Contacts:
Carolyn Anderson
+33 1-64-50-20-11

Copyright © AlphaGalileo

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

UK NANOSAFETY GROUP publishes 2nd Edition of guidance to support safe working with nanomaterials May 30th, 2016

Fast, stretchy circuits could yield new wave of wearable electronics May 30th, 2016

Automating DNA origami opens door to many new uses: Like 3-D printing did for larger objects, method makes it easy to build nanoparticles out of DNA May 30th, 2016

Simple attraction: Researchers control protein release from nanoparticles without encapsulation: U of T Engineering discovery stands to improve reliability and fabrication process for treatments to conditions such as spinal cord damage and stroke May 28th, 2016

Doubling down on Schrödinger's cat May 27th, 2016

Imaging

Scientists illuminate a hidden regulator in gene transcription: New super-resolution technique visualizes important role of short-lived enzyme clusters May 27th, 2016

Light can 'heal' defects in new solar cell materials: Defects in some new electronic materials can be removed by making ions move under illumination May 24th, 2016

More light on cancer: Scientists created nanoparticles to highlight cancer cells May 21st, 2016

Laboratories

Revealing the nature of magnetic interactions in manganese oxide: New technique for probing local magnetic interactions confirms 'superexchange' model that explains how the material gets its long-range magnetic order May 25th, 2016

ORNL demonstrates large-scale technique to produce quantum dots May 21st, 2016

Govt.-Legislation/Regulation/Funding/Policy

Scientists illuminate a hidden regulator in gene transcription: New super-resolution technique visualizes important role of short-lived enzyme clusters May 27th, 2016

Doubling down on Schrödinger's cat May 27th, 2016

Harnessing solar and wind energy in one device could power the 'Internet of Things' May 26th, 2016

Thermal modification of wood and a complex study of its properties by magnetic resonance May 26th, 2016

Nanomedicine

Automating DNA origami opens door to many new uses: Like 3-D printing did for larger objects, method makes it easy to build nanoparticles out of DNA May 30th, 2016

Simple attraction: Researchers control protein release from nanoparticles without encapsulation: U of T Engineering discovery stands to improve reliability and fabrication process for treatments to conditions such as spinal cord damage and stroke May 28th, 2016

Scientists illuminate a hidden regulator in gene transcription: New super-resolution technique visualizes important role of short-lived enzyme clusters May 27th, 2016

Supercrystals with new architecture can enhance drug synthesis May 24th, 2016

Discoveries

Fast, stretchy circuits could yield new wave of wearable electronics May 30th, 2016

Automating DNA origami opens door to many new uses: Like 3-D printing did for larger objects, method makes it easy to build nanoparticles out of DNA May 30th, 2016

Simple attraction: Researchers control protein release from nanoparticles without encapsulation: U of T Engineering discovery stands to improve reliability and fabrication process for treatments to conditions such as spinal cord damage and stroke May 28th, 2016

Scientists illuminate a hidden regulator in gene transcription: New super-resolution technique visualizes important role of short-lived enzyme clusters May 27th, 2016

Announcements

UK NANOSAFETY GROUP publishes 2nd Edition of guidance to support safe working with nanomaterials May 30th, 2016

Fast, stretchy circuits could yield new wave of wearable electronics May 30th, 2016

Automating DNA origami opens door to many new uses: Like 3-D printing did for larger objects, method makes it easy to build nanoparticles out of DNA May 30th, 2016

Simple attraction: Researchers control protein release from nanoparticles without encapsulation: U of T Engineering discovery stands to improve reliability and fabrication process for treatments to conditions such as spinal cord damage and stroke May 28th, 2016

Interviews/Book Reviews/Essays/Reports/Podcasts/Journals/White papers

UK NANOSAFETY GROUP publishes 2nd Edition of guidance to support safe working with nanomaterials May 30th, 2016

Fast, stretchy circuits could yield new wave of wearable electronics May 30th, 2016

Automating DNA origami opens door to many new uses: Like 3-D printing did for larger objects, method makes it easy to build nanoparticles out of DNA May 30th, 2016

Simple attraction: Researchers control protein release from nanoparticles without encapsulation: U of T Engineering discovery stands to improve reliability and fabrication process for treatments to conditions such as spinal cord damage and stroke May 28th, 2016

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







Car Brands
Buy website traffic