Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Toward a urine test for detecting blood clots

Blood clots, which can cause life-threatening conditions such as strokes and heart attacks, are a challenge to detect, but scientists are now reporting progress in the form of a urine test.
Credit: iStock/Thinkstock
Blood clots, which can cause life-threatening conditions such as strokes and heart attacks, are a challenge to detect, but scientists are now reporting progress in the form of a urine test.

Credit: iStock/Thinkstock

Abstract:
Detecting dangerous blood clots, which can cause life-threatening conditions such as strokes and heart attacks, leading causes of death for men and women in the U.S., has been a coveted and elusive goal. But scientists are now reporting progress in the form of a simple urine test. Their study, in which they demonstrated that the test works using laboratory mice, appears in the journal ACS Nano.

Toward a urine test for detecting blood clots

Washington, DC | Posted on October 16th, 2013

Sangeeta N. Bhatia and colleagues, including lead author and Ph.D. candidate Kevin Lin and postdoctoral fellow Gabriel Kwong, point out that blood clots — clumps of platelets and fibrin proteins — can threaten to choke off blood flow and lead to a wide range of serious and sometimes fatal conditions including atherosclerosis and stroke. Usually, blood clots are a good thing. They form a plug that stops the bleeding after an injury. But sometimes, a clot forms when it really isn't needed, such as when a person sits too long on a long-distance flight and develops "deep-vein thrombosis." In that case, a clot forms in the leg, blocking blood flow and causing leg pain. But it also can dislodge and move throughout the body to the heart or even the brain, which is life-threatening. Diagnosing a blood clot, or thrombosis, is tricky, however, and current clinical tests aren't always reliable. Bhatia's team wanted to develop a simple and more reliable way to test for these obstructive blood clots.

They describe development and testing of "synthetic biomarkers" — lab-made materials for detecting what is going on in the body. They added small pieces of proteins called peptides onto nanomaterials that are similar to those already approved and used in the clinic. They injected the tiny nanomaterials into mice, which are stand-ins for humans. The peptides got chopped up if a blood clot was actively forming in the mice, and those peptide fragments were detected in a simple urine test. "Our results demonstrate that synthetic biomarkers can be engineered to sense vascular diseases remotely from the urine and may allow applications in point-of-care diagnostics," the researchers state.

The authors acknowledge funding from the Koch Institute Frontier Research Program and the Kathy and Curt Marble Cancer Research Fund, the Mazumdar-Shaw International Oncology Fellows Program, the MIT Deshpande Center, CCNE, the Ruth L. Kirschstein National Research Service Award, the Burroughs Wellcome Fund and the Howard Hughes Medical Institute.

####

About American Chemical Society
The American Chemical Society is a nonprofit organization chartered by the U.S. Congress. With more than 163,000 members, ACS is the world’s largest scientific society and a global leader in providing access to chemistry-related research through its multiple databases, peer-reviewed journals and scientific conferences. Its main offices are in Washington, D.C., and Columbus, Ohio.

For more information, please click here

Contacts:
Sangeeta N. Bhatia, Ph.D.
Massachusetts Institute of Technology
Broad Institute of Harvard and MIT
Howard Hughes Medical Institute
Cambridge, Mass. 02139
and
Brigham and Women’s Hospital
Boston, Mass. 02115


General Inquiries:
Michael Bernstein

202-872-6042

Science Inquiries:
Katie Cottingham, Ph.D.

301-775-8455

Copyright © American Chemical Society

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

DOWNLOAD FULL-TEXT ARTICLE - "Nanoparticles That Sense Thrombin Activity as Synthetic Urinary Biomarkers of Thrombosis"

Related News Press

News and information

GLOBALFOUNDRIES and Chengdu Partner to Expand FD-SOI Ecosystem in China: More than $100M investment to establish a center of excellence for FDXTM FD-SOI design May 23rd, 2017

Zap! Graphene is bad news for bacteria: Rice, Ben-Gurion universities show laser-induced graphene kills bacteria, resists biofouling May 22nd, 2017

Leti Will Demo World’s-first WVGA 10-µm Pitch GaN Microdisplays for Augmented Reality Video at Display Week in Los Angles: Invited Paper also Will Present Leti’s Success with New Augmented Reality Technology That Reduces Pixel Pitch to Less than 5 Microns May 22nd, 2017

Graphene-nanotube hybrid boosts lithium metal batteries: Rice University prototypes store 3 times the energy of lithium-ion batteries May 19th, 2017

Nanomedicine

Zap! Graphene is bad news for bacteria: Rice, Ben-Gurion universities show laser-induced graphene kills bacteria, resists biofouling May 22nd, 2017

Sensors detect disease markers in breath May 19th, 2017

Oddball enzyme provides easy path to synthetic biomaterials May 17th, 2017

The brighter side of twisted polymers: Conjugated polymers designed with a twist produce tiny, brightly fluorescent particles with broad applications May 16th, 2017

Discoveries

Zap! Graphene is bad news for bacteria: Rice, Ben-Gurion universities show laser-induced graphene kills bacteria, resists biofouling May 22nd, 2017

Sensors detect disease markers in breath May 19th, 2017

Graphene-nanotube hybrid boosts lithium metal batteries: Rice University prototypes store 3 times the energy of lithium-ion batteries May 19th, 2017

Plasmon-powered upconversion nanocrystals for enhanced bioimaging and polarized emission: Plasmonic gold nanorods brighten lanthanide-doped upconversion superdots for improved multiphoton bioimaging contrast and enable polarization-selective nonlinear emissions for novel nanoscal May 19th, 2017

Announcements

GLOBALFOUNDRIES and Chengdu Partner to Expand FD-SOI Ecosystem in China: More than $100M investment to establish a center of excellence for FDXTM FD-SOI design May 23rd, 2017

Zap! Graphene is bad news for bacteria: Rice, Ben-Gurion universities show laser-induced graphene kills bacteria, resists biofouling May 22nd, 2017

Leti Will Demo World’s-first WVGA 10-µm Pitch GaN Microdisplays for Augmented Reality Video at Display Week in Los Angles: Invited Paper also Will Present Leti’s Success with New Augmented Reality Technology That Reduces Pixel Pitch to Less than 5 Microns May 22nd, 2017

Graphene-nanotube hybrid boosts lithium metal batteries: Rice University prototypes store 3 times the energy of lithium-ion batteries May 19th, 2017

Interviews/Book Reviews/Essays/Reports/Podcasts/Journals/White papers

Zap! Graphene is bad news for bacteria: Rice, Ben-Gurion universities show laser-induced graphene kills bacteria, resists biofouling May 22nd, 2017

Sensors detect disease markers in breath May 19th, 2017

Graphene-nanotube hybrid boosts lithium metal batteries: Rice University prototypes store 3 times the energy of lithium-ion batteries May 19th, 2017

Plasmon-powered upconversion nanocrystals for enhanced bioimaging and polarized emission: Plasmonic gold nanorods brighten lanthanide-doped upconversion superdots for improved multiphoton bioimaging contrast and enable polarization-selective nonlinear emissions for novel nanoscal May 19th, 2017

Grants/Sponsored Research/Awards/Scholarships/Gifts/Contests/Honors/Records

Zap! Graphene is bad news for bacteria: Rice, Ben-Gurion universities show laser-induced graphene kills bacteria, resists biofouling May 22nd, 2017

Gas gives laser-induced graphene super properties: Rice University study shows inexpensive material can be superhydrophilic or superhydrophobic May 15th, 2017

Fed grant backs nanofiber development: Rice University joins Department of Energy 'Next Generation Machines' initiative May 10th, 2017

'Hot' electrons don't mind the gap: Rice University scientists find nanogaps in plasmonic gold wires enhance voltage when excited May 8th, 2017

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project