Nanotechnology Now

Our NanoNews Digest Sponsors



Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > Toward a urine test for detecting blood clots

Blood clots, which can cause life-threatening conditions such as strokes and heart attacks, are a challenge to detect, but scientists are now reporting progress in the form of a urine test.
Credit: iStock/Thinkstock
Blood clots, which can cause life-threatening conditions such as strokes and heart attacks, are a challenge to detect, but scientists are now reporting progress in the form of a urine test.

Credit: iStock/Thinkstock

Abstract:
Detecting dangerous blood clots, which can cause life-threatening conditions such as strokes and heart attacks, leading causes of death for men and women in the U.S., has been a coveted and elusive goal. But scientists are now reporting progress in the form of a simple urine test. Their study, in which they demonstrated that the test works using laboratory mice, appears in the journal ACS Nano.

Toward a urine test for detecting blood clots

Washington, DC | Posted on October 16th, 2013

Sangeeta N. Bhatia and colleagues, including lead author and Ph.D. candidate Kevin Lin and postdoctoral fellow Gabriel Kwong, point out that blood clots — clumps of platelets and fibrin proteins — can threaten to choke off blood flow and lead to a wide range of serious and sometimes fatal conditions including atherosclerosis and stroke. Usually, blood clots are a good thing. They form a plug that stops the bleeding after an injury. But sometimes, a clot forms when it really isn't needed, such as when a person sits too long on a long-distance flight and develops "deep-vein thrombosis." In that case, a clot forms in the leg, blocking blood flow and causing leg pain. But it also can dislodge and move throughout the body to the heart or even the brain, which is life-threatening. Diagnosing a blood clot, or thrombosis, is tricky, however, and current clinical tests aren't always reliable. Bhatia's team wanted to develop a simple and more reliable way to test for these obstructive blood clots.

They describe development and testing of "synthetic biomarkers" — lab-made materials for detecting what is going on in the body. They added small pieces of proteins called peptides onto nanomaterials that are similar to those already approved and used in the clinic. They injected the tiny nanomaterials into mice, which are stand-ins for humans. The peptides got chopped up if a blood clot was actively forming in the mice, and those peptide fragments were detected in a simple urine test. "Our results demonstrate that synthetic biomarkers can be engineered to sense vascular diseases remotely from the urine and may allow applications in point-of-care diagnostics," the researchers state.

The authors acknowledge funding from the Koch Institute Frontier Research Program and the Kathy and Curt Marble Cancer Research Fund, the Mazumdar-Shaw International Oncology Fellows Program, the MIT Deshpande Center, CCNE, the Ruth L. Kirschstein National Research Service Award, the Burroughs Wellcome Fund and the Howard Hughes Medical Institute.

####

About American Chemical Society
The American Chemical Society is a nonprofit organization chartered by the U.S. Congress. With more than 163,000 members, ACS is the world’s largest scientific society and a global leader in providing access to chemistry-related research through its multiple databases, peer-reviewed journals and scientific conferences. Its main offices are in Washington, D.C., and Columbus, Ohio.

For more information, please click here

Contacts:
Sangeeta N. Bhatia, Ph.D.
Massachusetts Institute of Technology
Broad Institute of Harvard and MIT
Howard Hughes Medical Institute
Cambridge, Mass. 02139
and
Brigham and Women’s Hospital
Boston, Mass. 02115


General Inquiries:
Michael Bernstein

202-872-6042

Science Inquiries:
Katie Cottingham, Ph.D.

301-775-8455

Copyright © American Chemical Society

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

DOWNLOAD FULL-TEXT ARTICLE - "Nanoparticles That Sense Thrombin Activity as Synthetic Urinary Biomarkers of Thrombosis"

Related News Press

News and information

Future flexible electronics based on carbon nanotubes: Study in Applied Physics Letters show how to improve nanotube transistor and circuit performance with fluoropolymers September 23rd, 2014

Nanotubes help healing hearts keep the beat: Rice University, Texas Children’s Hospital patch for defects enhances electrical connections between cells September 23rd, 2014

Immune system is key ally in cyberwar against cancer: Rice University study yields new two-step strategy for weakening cancer September 23rd, 2014

Los Alamos Researchers Uncover New Properties in Nanocomposite Oxide Ceramics for Reactor Fuel, Fast-Ion Conductors: Misfit dislocations are key to transport properties across material interfaces September 23rd, 2014

Nanomedicine

Nanotubes help healing hearts keep the beat: Rice University, Texas Children’s Hospital patch for defects enhances electrical connections between cells September 23rd, 2014

Immune system is key ally in cyberwar against cancer: Rice University study yields new two-step strategy for weakening cancer September 23rd, 2014

Production of Organometallic Frameworks in Least Possible Time September 23rd, 2014

Engineered proteins stick like glue — even in water: New adhesives based on mussel proteins could be useful for naval or medical applications September 22nd, 2014

Discoveries

Future flexible electronics based on carbon nanotubes: Study in Applied Physics Letters show how to improve nanotube transistor and circuit performance with fluoropolymers September 23rd, 2014

Nanotubes help healing hearts keep the beat: Rice University, Texas Children’s Hospital patch for defects enhances electrical connections between cells September 23rd, 2014

Immune system is key ally in cyberwar against cancer: Rice University study yields new two-step strategy for weakening cancer September 23rd, 2014

Los Alamos Researchers Uncover New Properties in Nanocomposite Oxide Ceramics for Reactor Fuel, Fast-Ion Conductors: Misfit dislocations are key to transport properties across material interfaces September 23rd, 2014

Announcements

Future flexible electronics based on carbon nanotubes: Study in Applied Physics Letters show how to improve nanotube transistor and circuit performance with fluoropolymers September 23rd, 2014

Nanotubes help healing hearts keep the beat: Rice University, Texas Children’s Hospital patch for defects enhances electrical connections between cells September 23rd, 2014

Immune system is key ally in cyberwar against cancer: Rice University study yields new two-step strategy for weakening cancer September 23rd, 2014

Los Alamos Researchers Uncover New Properties in Nanocomposite Oxide Ceramics for Reactor Fuel, Fast-Ion Conductors: Misfit dislocations are key to transport properties across material interfaces September 23rd, 2014

Interviews/Book Reviews/Essays/Reports/Podcasts/Journals

Southampton scientists grow a new challenger to graphene September 23rd, 2014

Future flexible electronics based on carbon nanotubes: Study in Applied Physics Letters show how to improve nanotube transistor and circuit performance with fluoropolymers September 23rd, 2014

Immune system is key ally in cyberwar against cancer: Rice University study yields new two-step strategy for weakening cancer September 23rd, 2014

Los Alamos Researchers Uncover New Properties in Nanocomposite Oxide Ceramics for Reactor Fuel, Fast-Ion Conductors: Misfit dislocations are key to transport properties across material interfaces September 23rd, 2014

Grants/Awards/Scholarships/Gifts/Contests/Honors/Records

New chip promising for tumor-targeting research September 22nd, 2014

SouthWest NanoTechnologies (SWeNT) Receives NIST Small Business Innovation Research (SBIR) Phase 1 Award to Produce Greater than 99% Semiconducting Single-Wall Carbon Nanotubes September 19th, 2014

Big Results Require Big Ambitions: Three young UCSB faculty receive CAREER awards from the National Science Foundation September 18th, 2014

Effective Nanotechnology Innovations to Receive Mustafa Prize September 16th, 2014

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE