Home > Press > Toward a urine test for detecting blood clots
Blood clots, which can cause life-threatening conditions such as strokes and heart attacks, are a challenge to detect, but scientists are now reporting progress in the form of a urine test. Credit: iStock/Thinkstock |
Abstract:
Detecting dangerous blood clots, which can cause life-threatening conditions such as strokes and heart attacks, leading causes of death for men and women in the U.S., has been a coveted and elusive goal. But scientists are now reporting progress in the form of a simple urine test. Their study, in which they demonstrated that the test works using laboratory mice, appears in the journal ACS Nano.
Sangeeta N. Bhatia and colleagues, including lead author and Ph.D. candidate Kevin Lin and postdoctoral fellow Gabriel Kwong, point out that blood clots — clumps of platelets and fibrin proteins — can threaten to choke off blood flow and lead to a wide range of serious and sometimes fatal conditions including atherosclerosis and stroke. Usually, blood clots are a good thing. They form a plug that stops the bleeding after an injury. But sometimes, a clot forms when it really isn't needed, such as when a person sits too long on a long-distance flight and develops "deep-vein thrombosis." In that case, a clot forms in the leg, blocking blood flow and causing leg pain. But it also can dislodge and move throughout the body to the heart or even the brain, which is life-threatening. Diagnosing a blood clot, or thrombosis, is tricky, however, and current clinical tests aren't always reliable. Bhatia's team wanted to develop a simple and more reliable way to test for these obstructive blood clots.
They describe development and testing of "synthetic biomarkers" — lab-made materials for detecting what is going on in the body. They added small pieces of proteins called peptides onto nanomaterials that are similar to those already approved and used in the clinic. They injected the tiny nanomaterials into mice, which are stand-ins for humans. The peptides got chopped up if a blood clot was actively forming in the mice, and those peptide fragments were detected in a simple urine test. "Our results demonstrate that synthetic biomarkers can be engineered to sense vascular diseases remotely from the urine and may allow applications in point-of-care diagnostics," the researchers state.
The authors acknowledge funding from the Koch Institute Frontier Research Program and the Kathy and Curt Marble Cancer Research Fund, the Mazumdar-Shaw International Oncology Fellows Program, the MIT Deshpande Center, CCNE, the Ruth L. Kirschstein National Research Service Award, the Burroughs Wellcome Fund and the Howard Hughes Medical Institute.
####
About American Chemical Society
The American Chemical Society is a nonprofit organization chartered by the U.S. Congress. With more than 163,000 members, ACS is the world’s largest scientific society and a global leader in providing access to chemistry-related research through its multiple databases, peer-reviewed journals and scientific conferences. Its main offices are in Washington, D.C., and Columbus, Ohio.
For more information, please click here
Contacts:
Sangeeta N. Bhatia, Ph.D.
Massachusetts Institute of Technology
Broad Institute of Harvard and MIT
Howard Hughes Medical Institute
Cambridge, Mass. 02139
and
Brigham and Women’s Hospital
Boston, Mass. 02115
General Inquiries:
Michael Bernstein
202-872-6042
Science Inquiries:
Katie Cottingham, Ph.D.
301-775-8455
Copyright © American Chemical Society
If you have a comment, please Contact us.Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.
Related Links |
Related News Press |
News and information
Researchers develop artificial building blocks of life March 8th, 2024
Nanomedicine
High-tech 'paint' could spare patients repeated surgeries March 8th, 2024
Researchers develop artificial building blocks of life March 8th, 2024
Discoveries
What heat can tell us about battery chemistry: using the Peltier effect to study lithium-ion cells March 8th, 2024
Researchers’ approach may protect quantum computers from attacks March 8th, 2024
High-tech 'paint' could spare patients repeated surgeries March 8th, 2024
Nanoscale CL thermometry with lanthanide-doped heavy-metal oxide in TEM March 8th, 2024
Announcements
What heat can tell us about battery chemistry: using the Peltier effect to study lithium-ion cells March 8th, 2024
Nanoscale CL thermometry with lanthanide-doped heavy-metal oxide in TEM March 8th, 2024
Interviews/Book Reviews/Essays/Reports/Podcasts/Journals/White papers/Posters
Researchers develop artificial building blocks of life March 8th, 2024
Nanoscale CL thermometry with lanthanide-doped heavy-metal oxide in TEM March 8th, 2024
Grants/Sponsored Research/Awards/Scholarships/Gifts/Contests/Honors/Records
'Sudden death' of quantum fluctuations defies current theories of superconductivity: Study challenges the conventional wisdom of superconducting quantum transitions January 12th, 2024
The latest news from around the world, FREE | ||
Premium Products | ||
Only the news you want to read!
Learn More |
||
Full-service, expert consulting
Learn More |
||