Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > Zetasizer Nano used in studies on particulate vaccines for respiratory administration

The Zetasizer Nano particle characterization system
The Zetasizer Nano particle characterization system

Abstract:
Researchers in the Department of Pharmaceutics and Biopharmaceutics at Kiel University in Germany, are using a Zetasizer Nano system from Malvern Instruments in their work on particulate vaccines formulations for administration via the respiratory tract. Dr. Regina Scherließ leads the research group whose many recent publications include ‘PLGA nanoparticles for vaccine delivery to the respiratory tract [1] and ‘Overcoming the challenges of nasal vaccines through intelligent particle engineering' [2].

Zetasizer Nano used in studies on particulate vaccines for respiratory administration

Malvern, UK | Posted on October 14th, 2013

"We formulate nanoparticles as antigen carriers and incorporate them into larger particles, known as nano-in-microparticles, or NiM, of a size feasible for deposition in the nose or lung," explains Dr Scherließ. "We normally work with dry powder formulations, so the NiM will be dried, usually spray dried, at some point in the formulation process. As the particulate antigen carrier has to be taken up as a particle by the relevant immune cells, we mostly target dendritic cells and macrophages. Nanoparticle size is an important criterion for our formulations and we routinely measure this with the Zetasizer Nano."

Particle size has to be measured directly after preparation and also upon redispersion of the NiM formulation. Redispersion often has to take place in physiological or cell culture media, and at this point the Zetasizer Nano is used to check for aggregates and particle size stability.

"We've also used the Zetasizer Nano for another project where we looked at stabilization of haemaglutinin during spray drying," continued Dr Scherließ, "and as well in a project characterizing chitosan as an adjuvant. Here, we used the Zetasizer to determine the molecular weight of chitosans of different qualities."

The Malvern Zetasizer range provides both exceptionally high performance and entry level systems that incorporate combinations of a particle size analyzer, zeta potential analyzer, molecular weight analyzer, protein mobility and microrheology measurements. Particles and molecules from less than a nanometer in size to several microns can be analyzed by a range of variants to suit specific applications and budget.

Details of Malvern's Zetasizer range are available at www.malvern.com/zetasizer
For information about the research of Dr Scherließ visit www.uni-kiel.de/pharmazie/technologie/eng/publications.htm

Malvern, Malvern Instruments and Zetasizer are registered trademarks of Malvern Instruments Ltd

####

About Malvern Instruments
Malvern provides the materials and biophysical characterization technology and expertise that enables scientists and engineers to understand and control the properties of dispersed systems. These systems range from proteins and polymers in solution, particle and nanoparticle suspensions and emulsions, through to sprays and aerosols, industrial bulk powders and high concentration slurries. Used at all stages of research, development and manufacturing, Malvern’s materials characterization instruments provide critical information that helps accelerate research and product development, enhance and maintain product quality and optimize process efficiency.

Our products reflect Malvern’s drive to exploit the latest technological innovations and our commitment to maximizing the potential of established techniques. They are used by both industry and academia, in sectors ranging from pharmaceuticals and biopharmaceuticals to bulk chemicals, cement, plastics and polymers, energy and the environment.

Malvern systems are used to measure particle size, particle shape, zeta potential, protein charge, molecular weight, mass, size and conformation, rheological properties and for chemical identification, advancing the understanding of dispersed systems across many different industries and applications.

Headquartered in Malvern, UK, Malvern Instruments has subsidiary organizations in all major European markets, North America, China, Japan and Korea, a joint venture in India, a global distributor network and applications laboratories around the world.

Facebook: MalvernInstruments
Blog: www.materials-talks.com
Youtube: malverninstruments
Linked-In: malvern-instruments
Twitter: malvern_news
Google +: https://plus.google.com/105749461389316404960/posts#105749461389316404960/posts

For more information, please click here

Contacts:
For press information, please contact:

Trish Appleton
Kapler Communications
Phoenix House, Phoenix Park
Eaton Socon, Cambridgeshire, PE19 8EP, UK
Tel: +44 (0)1480 471059
Fax: +44 (0)1480 471069


USA contact:

Marisa Fraser
Malvern Instruments Inc.
117 Flanders Road
Westborough, MA 01581-1042 USA
Tel: +1 508 768 6400
Fax: +1 508 768 6403


Please send sales enquiries to:

Alison Vines
Malvern Instruments Ltd
Enigma Business Park, Grovewood Road
Malvern, Worcestershire WR14 1XZ UK
Tel: +44 (0) 1684 892456
Fax: +44 (0) 1684 892789

Copyright © Malvern Instruments

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Scientists Capture Ultrafast Snapshots of Light-Driven Superconductivity: X-rays reveal how rapidly vanishing 'charge stripes' may be behind laser-induced high-temperature superconductivity April 16th, 2014

'Life Redesigned: The Emergence of Synthetic Biology' Lecture at Brookhaven Lab on Wednesday, April 30: Biomedical Engineer James Collins to Speak for BSA Distinguished Lecture Series April 16th, 2014

ECHA Planning Workshop on Regulatory Challenges in the Risk Assessment of Nanomaterials April 16th, 2014

Lumerical files a provisional patent that extends the standard eigenmode expansion propagation technique to better address waveguide component design. Lumerical’s EME propagation tool will address a wide set of waveguide applications in silicon photonics and integrated optics April 16th, 2014

Announcements

UT Arlington physicist creates new nanoparticle for cancer therapy April 16th, 2014

Relieving electric vehicle range anxiety with improved batteries: Lithium-sulfur batteries last longer with nanomaterial-packed cathode April 16th, 2014

Aerotech X-Y ball-screw stage for economical high performance Planar positioning April 16th, 2014

Energy Research Facility Construction Project at Brookhaven Lab Wins U.S. Energy Secretary's Achievement Award April 16th, 2014

Tools

Scientists Capture Ultrafast Snapshots of Light-Driven Superconductivity: X-rays reveal how rapidly vanishing 'charge stripes' may be behind laser-induced high-temperature superconductivity April 16th, 2014

Aerotech X-Y ball-screw stage for economical high performance Planar positioning April 16th, 2014

Malvern reports on the publication of the 1000th peer-reviewed paper to cite NanoSight’s Nanoparticle Tracking Analysis, NTA April 16th, 2014

JPK announces expansion of its global sales and service activities in China and USA April 15th, 2014

NanoNews-Digest
The latest news from around the world, FREE







  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE