Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Great potential for faster diagnoses with new method

Left: Electron microscope image of nanowire forest. Middle: Diagram of a single nanowire with proteins (red molecules) which captures a different type proteins (green molecules) from a solution. Right: Typical fluorescence microscope image of proteins captures on nanowires (seen from above).
Left: Electron microscope image of nanowire forest. Middle: Diagram of a single nanowire with proteins (red molecules) which captures a different type proteins (green molecules) from a solution. Right: Typical fluorescence microscope image of proteins captures on nanowires (seen from above).

Abstract:
The more accurately we can diagnose a disease, the greater the chance that the patient will survive. That is why many researchers are working to improve the quality of the diagnostic process. Researchers at the Nano-Science Center, University of Copenhagen have discovered a method that will make the process faster, cheaper and more accurate. This is possible, because they are combining advanced tools used in physics for research in biology at nanoscale, two scientific disciplines usually very distant from each other.

Great potential for faster diagnoses with new method

Copenhagen, Denmark | Posted on October 3rd, 2013

Many diseases can be diagnosed using so-called biomarkers. There are substances, for example, that can be measured in a blood sample, which shows that the patient is suffering from the disease in question. These biomarkers are often proteins that are found in very small quantities in the blood, making it difficult to detect them. By measuring them, the diagnosing is more precise and many diseases can be detected very early, before the patient develops severe symptoms.

We have developed a method in which we optimise the analysis of the proteins. A central point of this method is the use of nanowires to hold the proteins while we analyse them. It is unique, explains Katrine R. Rostgaard, a PhD student at the Nano-Science Center, Department of Chemistry, University of Copenhagen.

Researchers normally use small plates to hold the proteins when they need to be analysed, but by using nanowires, which are cylindrical structures having a diameter of about 1/1000th of a human hair, they add a third dimension to the sample. The nanowires stand up like a little forest, creating a much greater surface area to hold the proteins because they can sit on all sides of the nanowire.

- With greater area, we can hold more proteins at once. This makes it possible to measure for multiple biomarkers simultaneously and it increases the signal, thereby providing a better quality of diagnosis, says Katrine R. Rostgaard about the method, which has just been published in the journal Nanoscale.

Profitable method for diagnosing
The research is done at the nanoscale on small size samples. The forests of nanowires are used to capture the proteins they want to study directly. When examining the proteins, you can reuse the nanowires by performing a multiple tests on the same protein. This simplifies the workflow in the laboratory tremendously in comparison to the conventional method, where researchers have to start over with a new plate to hold the proteins every time they perform a new analysis. In this way, the method helps to make the diagnostic process more environmentally friendly and economically viable for use in, for example, industry.

- We know that several major biotech companies will be interested in our new method and find potential applications, though it requires improvements before it is ready for use in the industry, explains Karen Martinez, research group leader of the Nanobio group at the Nano-Science Center, Department of Chemistry, University of Copenhagen.

The work is part of two larger projects, ANaCell and UNIK Center for Synthetic Biology, which is financed by The Danish Council for Strategic Research and the Ministry of Science, Technology and Innovation.

####

For more information, please click here

Contacts:
Karen Martinez

(45) 30-30-04-75

Copyright © University of Copenhagen

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

University of Akron researchers find thin layers of water can become ice-like at room temperature: Results could lead to an assortment of anti-friction solutions August 30th, 2016

Nanocatalysis for organic chemistry: This research article by Dr. Qien Xu et al. is published in Current Organic Chemistry, Volume 20, Issue 19, 2016 August 30th, 2016

Continuous roll-process technology for transferring and packaging flexible LSI August 29th, 2016

Meteorite impact on a nano scale August 29th, 2016

Designing ultrasound tools with Lego-like proteins August 29th, 2016

Imaging

Meteorite impact on a nano scale August 29th, 2016

Designing ultrasound tools with Lego-like proteins August 29th, 2016

Forces of nature: Interview with microscopy innovators Gerd Binnig and Christoph Gerber August 26th, 2016

Discoveries

University of Akron researchers find thin layers of water can become ice-like at room temperature: Results could lead to an assortment of anti-friction solutions August 30th, 2016

Nanocatalysis for organic chemistry: This research article by Dr. Qien Xu et al. is published in Current Organic Chemistry, Volume 20, Issue 19, 2016 August 30th, 2016

Continuous roll-process technology for transferring and packaging flexible LSI August 29th, 2016

Meteorite impact on a nano scale August 29th, 2016

Announcements

University of Akron researchers find thin layers of water can become ice-like at room temperature: Results could lead to an assortment of anti-friction solutions August 30th, 2016

Nanocatalysis for organic chemistry: This research article by Dr. Qien Xu et al. is published in Current Organic Chemistry, Volume 20, Issue 19, 2016 August 30th, 2016

Continuous roll-process technology for transferring and packaging flexible LSI August 29th, 2016

Meteorite impact on a nano scale August 29th, 2016

Tools

Designing ultrasound tools with Lego-like proteins August 29th, 2016

Nanofiber scaffolds demonstrate new features in the behavior of stem and cancer cells August 25th, 2016

50 years after the release of the film 'Fantastic Voyage,' science upstages fiction: Science upstages fiction with nanorobotic agents designed to travel in the human body to treat cancer August 25th, 2016

University of Puerto Rico and NASA back in the news XEI reports August 23rd, 2016

Nanobiotechnology

Designing ultrasound tools with Lego-like proteins August 29th, 2016

Analog DNA circuit does math in a test tube: DNA computers could one day be programmed to diagnose and treat disease August 25th, 2016

Nanofiber scaffolds demonstrate new features in the behavior of stem and cancer cells August 25th, 2016

Johns Hopkins scientists track metabolic pathways to find drug combination for pancreatic cancer August 25th, 2016

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







Car Brands
Buy website traffic