Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Method developed at UT Arlington allows quantitative nanoscopic imaging through silicon

Mohanty
Mohanty

Abstract:
A team of scientists from The University of Texas at Arlington and MIT has figured out how to quantitatively observe cellular processes taking place on so-called "lab on a chip" devices in a silicon environment.

Method developed at UT Arlington allows quantitative nanoscopic imaging through silicon

Arlington, TX | Posted on October 2nd, 2013

The new technology will be useful in drug development as well as disease diagnosis, researchers say.

In a paper published in Nature's online journal Scientific Reports, the team said it overcame past limitations on quantitative microscopy through an opaque media by working with a new combination of near infrared light and a technique called quantitative phase imaging. Quantitative phase imaging is about a decade old. It uses shifts in phases of light, not staining techniques, to aid specimen imaging - earning the term "label-free."

"To the best of our knowledge, this is the first demonstration of quantitative phase imaging of cellular structure and function in silicon environment," said Assistant Professor of Physics Samarendra Mohanty, head of the Biophysics and Physiology Laboratory at UT Arlington and corresponding author on the paper.

The UT Arlington/MIT team was able to prove success in analyzing specimens through a silicon wafer in two instances. In one, they accomplished full-field imaging of the features of red blood cells to nanometer thickness accuracy. In another, they observed dynamic variation of human embryonic kidney cells in response to change in salt concentration. Mohanty believes that his group's current work on near infrared quantitative phase imaging can lead to non-invasive, label-free monitoring of neuronal activities.

Additional co-authors include: Bipin Joshi and Nelson Cardenas, of UT Arlington; and Ishan Barman, Narahara Chari Dingari, Jaqueline S. Soares and Ramachandra R. Dasari, all of MIT.

"Silicon-based micro devices known as labs-on-a-chip are revolutionizing high throughput analysis of cells and molecules for disease diagnosis and screening of drug effects. However, very little progress has been made in the optical characterization of samples in these systems," said Joshi, a recent graduate and lead author on the paper. "The technology we've developed is well-suited to meet this need."

Barman, now an assistant professor at Johns Hopkins University, said the new paper is a prime example of the type of research he hopes to do - projects pulled by needs of the biomedical community and continually pushing the edge of biophotonic solutions.

"We envision that this significantly expands the visualization possible in silicon based microelectronic and micromechanical devices," he said.

Mohanty's group has recently combined the near infrared quantitative phase imaging with near-infrared optical tweezers for tomographic imaging of cells [N. Cardenas, and S. K. Mohanty, "Optical tweezers assisted quantitative phase imaging led to thickness mapping of red blood cells", Appl. Phys. Lett., 103, 013703 (2013)].

The joint UT Arlington/ MIT research was supported by Nanoscope Technologies and funded in part by a National Institute of Biomedical Imaging and Bioengineering grant.

####

About University of Texas at Arlington
The University of Texas at Arlington is a comprehensive institution of about 33,000 students and more than 2,200 faculty members in the heart of North Texas. It is the second largest school in The University of Texas System. Visit www.uta.edu to learn more.

For more information, please click here

Contacts:
Traci Peterson

Office:817-272-9208
Cell:817-521-5494

Copyright © University of Texas at Arlington

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

Related News Press

News and information

Research Study: MetaSOLTM Shatters Solar Panel Efficiency Forecasts with Innovative New Coating: Coating Provides 1.2 Percent Absolute Enhancement to Triple Junction Solar Cells December 2nd, 2016

Deep insights from surface reactions: Researchers use Stampede supercomputer to study new chemical sensing methods, desalination and bacterial energy production December 2nd, 2016

Quantum obstacle course changes material from superconductor to insulator December 1st, 2016

Throwing new light on printed organic solar cells December 1st, 2016

Imaging

Deep insights from surface reactions: Researchers use Stampede supercomputer to study new chemical sensing methods, desalination and bacterial energy production December 2nd, 2016

Controlled electron pulses November 30th, 2016

Lab-on-a-chip

Researchers use acoustic waves to move fluids at the nanoscale November 15th, 2016

IBM Lab-on-a-Chip Breakthrough Aims to Help Physicians Detect Cancer and Diseases at the Nanoscale: IBM scientists will collaborate with the Icahn School of Medicine at Mt. Sinai to test on prostate cancer August 1st, 2016

POSTECH researchers develop a control algorithm for more accurate lab-on-a-chip devices April 6th, 2016

Artificial molecules April 3rd, 2016

Nanomedicine

Nanobiotix Provides Update on Global Development of Lead Product NBTXR3: Seven clinical trials across the world: More than 2/3 of STS patients recruited in the “act.in.sarc” Phase II/III trial: Phase I/II prostate cancer trial now recruiting in the U.S. November 28th, 2016

From champagne bubbles, dance parties and disease to new nanomaterials: Understanding nucleation of protein filaments might help with Alzheimer's Disease and type 2 Diabetes November 24th, 2016

Nanopolymer-modified protein array can pinpoint hard-to-find cancer biomarker November 17th, 2016

Nanotechnology Treatment Found to Inhibit Mesothelioma Tumor Growth November 16th, 2016

Discoveries

Research Study: MetaSOLTM Shatters Solar Panel Efficiency Forecasts with Innovative New Coating: Coating Provides 1.2 Percent Absolute Enhancement to Triple Junction Solar Cells December 2nd, 2016

Deep insights from surface reactions: Researchers use Stampede supercomputer to study new chemical sensing methods, desalination and bacterial energy production December 2nd, 2016

Quantum obstacle course changes material from superconductor to insulator December 1st, 2016

Throwing new light on printed organic solar cells December 1st, 2016

Announcements

Research Study: MetaSOLTM Shatters Solar Panel Efficiency Forecasts with Innovative New Coating: Coating Provides 1.2 Percent Absolute Enhancement to Triple Junction Solar Cells December 2nd, 2016

Deep insights from surface reactions: Researchers use Stampede supercomputer to study new chemical sensing methods, desalination and bacterial energy production December 2nd, 2016

Quantum obstacle course changes material from superconductor to insulator December 1st, 2016

Throwing new light on printed organic solar cells December 1st, 2016

Interviews/Book Reviews/Essays/Reports/Podcasts/Journals/White papers

Deep insights from surface reactions: Researchers use Stampede supercomputer to study new chemical sensing methods, desalination and bacterial energy production December 2nd, 2016

Quantum obstacle course changes material from superconductor to insulator December 1st, 2016

Throwing new light on printed organic solar cells December 1st, 2016

New method for analyzing crystal structure: Exotic materials called photonic crystals reveal their internal characteristics with new method November 30th, 2016

Tools

Deep insights from surface reactions: Researchers use Stampede supercomputer to study new chemical sensing methods, desalination and bacterial energy production December 2nd, 2016

Controlled electron pulses November 30th, 2016

Scientists shrink electron gun to matchbox size: Terahertz technology has the potential to enable new applications November 25th, 2016

News from Quorum: The Agricultural Research Service of the USDA uses a Quorum Cryo-SEM preparation system for the study of mites, ticks and other soft bodied organisms November 22nd, 2016

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project