Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Method developed at UT Arlington allows quantitative nanoscopic imaging through silicon

Mohanty
Mohanty

Abstract:
A team of scientists from The University of Texas at Arlington and MIT has figured out how to quantitatively observe cellular processes taking place on so-called "lab on a chip" devices in a silicon environment.

Method developed at UT Arlington allows quantitative nanoscopic imaging through silicon

Arlington, TX | Posted on October 2nd, 2013

The new technology will be useful in drug development as well as disease diagnosis, researchers say.

In a paper published in Nature's online journal Scientific Reports, the team said it overcame past limitations on quantitative microscopy through an opaque media by working with a new combination of near infrared light and a technique called quantitative phase imaging. Quantitative phase imaging is about a decade old. It uses shifts in phases of light, not staining techniques, to aid specimen imaging - earning the term "label-free."

"To the best of our knowledge, this is the first demonstration of quantitative phase imaging of cellular structure and function in silicon environment," said Assistant Professor of Physics Samarendra Mohanty, head of the Biophysics and Physiology Laboratory at UT Arlington and corresponding author on the paper.

The UT Arlington/MIT team was able to prove success in analyzing specimens through a silicon wafer in two instances. In one, they accomplished full-field imaging of the features of red blood cells to nanometer thickness accuracy. In another, they observed dynamic variation of human embryonic kidney cells in response to change in salt concentration. Mohanty believes that his group's current work on near infrared quantitative phase imaging can lead to non-invasive, label-free monitoring of neuronal activities.

Additional co-authors include: Bipin Joshi and Nelson Cardenas, of UT Arlington; and Ishan Barman, Narahara Chari Dingari, Jaqueline S. Soares and Ramachandra R. Dasari, all of MIT.

"Silicon-based micro devices known as labs-on-a-chip are revolutionizing high throughput analysis of cells and molecules for disease diagnosis and screening of drug effects. However, very little progress has been made in the optical characterization of samples in these systems," said Joshi, a recent graduate and lead author on the paper. "The technology we've developed is well-suited to meet this need."

Barman, now an assistant professor at Johns Hopkins University, said the new paper is a prime example of the type of research he hopes to do - projects pulled by needs of the biomedical community and continually pushing the edge of biophotonic solutions.

"We envision that this significantly expands the visualization possible in silicon based microelectronic and micromechanical devices," he said.

Mohanty's group has recently combined the near infrared quantitative phase imaging with near-infrared optical tweezers for tomographic imaging of cells [N. Cardenas, and S. K. Mohanty, "Optical tweezers assisted quantitative phase imaging led to thickness mapping of red blood cells", Appl. Phys. Lett., 103, 013703 (2013)].

The joint UT Arlington/ MIT research was supported by Nanoscope Technologies and funded in part by a National Institute of Biomedical Imaging and Bioengineering grant.

####

About University of Texas at Arlington
The University of Texas at Arlington is a comprehensive institution of about 33,000 students and more than 2,200 faculty members in the heart of North Texas. It is the second largest school in The University of Texas System. Visit www.uta.edu to learn more.

For more information, please click here

Contacts:
Traci Peterson

Office:817-272-9208
Cell:817-521-5494

Copyright © University of Texas at Arlington

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

Related News Press

News and information

Picosun patents ALD nanolaminate to prevent electronics from overheating September 28th, 2016

Leti and Taiwanese Tech Organizations Sponsoring Workshop in Taipei on MEMS, IoT, Smart Lighting Applications, System Reliability & Security September 28th, 2016

Fighting cancer with sticky nanoparticles September 27th, 2016

Gold nanoparticles conjugated quercetin inhibits epithelial-mesenchymal transition, angiogenesis and invasiveness via EGFR/VEGFR-2 mediated pathway in breast cancer September 27th, 2016

Imaging

Leti and Taiwanese Tech Organizations Sponsoring Workshop in Taipei on MEMS, IoT, Smart Lighting Applications, System Reliability & Security September 28th, 2016

Lab-on-a-chip

IBM Lab-on-a-Chip Breakthrough Aims to Help Physicians Detect Cancer and Diseases at the Nanoscale: IBM scientists will collaborate with the Icahn School of Medicine at Mt. Sinai to test on prostate cancer August 1st, 2016

POSTECH researchers develop a control algorithm for more accurate lab-on-a-chip devices April 6th, 2016

Artificial molecules April 3rd, 2016

New microwave imaging approach opens a nanoscale view on processes in liquids: Technique can explore technologically and medically important processes that occur at boundaries between liquids and solids, such as in batteries or along cell membranes March 16th, 2016

Nanomedicine

Fighting cancer with sticky nanoparticles September 27th, 2016

Gold nanoparticles conjugated quercetin inhibits epithelial-mesenchymal transition, angiogenesis and invasiveness via EGFR/VEGFR-2 mediated pathway in breast cancer September 27th, 2016

Tattoo therapy could ease chronic disease: Rice-made nanoparticles tested at Baylor College of Medicine may help control autoimmune diseases September 23rd, 2016

BBI Solutions launches innovative conjugate blocking technology that enhances signal intensity for lateral flow immunoassays September 20th, 2016

Discoveries

Fighting cancer with sticky nanoparticles September 27th, 2016

Gold nanoparticles conjugated quercetin inhibits epithelial-mesenchymal transition, angiogenesis and invasiveness via EGFR/VEGFR-2 mediated pathway in breast cancer September 27th, 2016

UNAM develops successful nano edible coating which increases life food September 27th, 2016

Crystalline Fault Lines Provide Pathway for Solar Cell Current: New tomographic AFM imaging technique reveals that microstructural defects, generally thought to be detrimental, actually improve conductivity in cadmium telluride solar cells September 26th, 2016

Announcements

Picosun patents ALD nanolaminate to prevent electronics from overheating September 28th, 2016

Leti and Taiwanese Tech Organizations Sponsoring Workshop in Taipei on MEMS, IoT, Smart Lighting Applications, System Reliability & Security September 28th, 2016

Fighting cancer with sticky nanoparticles September 27th, 2016

Gold nanoparticles conjugated quercetin inhibits epithelial-mesenchymal transition, angiogenesis and invasiveness via EGFR/VEGFR-2 mediated pathway in breast cancer September 27th, 2016

Interviews/Book Reviews/Essays/Reports/Podcasts/Journals/White papers

Fighting cancer with sticky nanoparticles September 27th, 2016

Gold nanoparticles conjugated quercetin inhibits epithelial-mesenchymal transition, angiogenesis and invasiveness via EGFR/VEGFR-2 mediated pathway in breast cancer September 27th, 2016

Crystalline Fault Lines Provide Pathway for Solar Cell Current: New tomographic AFM imaging technique reveals that microstructural defects, generally thought to be detrimental, actually improve conductivity in cadmium telluride solar cells September 26th, 2016

Researchers at the Catalan Institute of Nanoscience and Nanotechnology show that bending semiconductors generates electricity September 26th, 2016

Tools

Oxford Instruments systems now facilitate water purification technology September 27th, 2016

Dr Barbara Armbruster promoted to Worldwide Sales and Marketing Director for XEI Scientific September 27th, 2016

Oxford Instruments is ‘Bringing the Nanoworld Together’ in India once again - 22 - 23 November 2016 | IISc Bangalore September 21st, 2016

Bruker Introduces Complete Commercial AFM-Based SECM Solution: PeakForce SECM Mode Enables Previously Unobtainable Electrochemical Information September 20th, 2016

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







Car Brands
Buy website traffic