Nanotechnology Now





Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > UW engineers invent programming language to build synthetic DNA

Yan Liang, L2XY2.com

An example of a chemical program. Here, A, B and C are different chemical species.
Yan Liang, L2XY2.com

An example of a chemical program. Here, A, B and C are different chemical species.

Abstract:
Similar to using Python or Java to write code for a computer, chemists soon could be able to use a structured set of instructions to "program" how DNA molecules interact in a test tube or cell.

UW engineers invent programming language to build synthetic DNA

Seattle, WA | Posted on September 30th, 2013

A team led by the University of Washington has developed a programming language for chemistry that it hopes will streamline efforts to design a network that can guide the behavior of chemical-reaction mixtures in the same way that embedded electronic controllers guide cars, robots and other devices. In medicine, such networks could serve as "smart" drug deliverers or disease detectors at the cellular level.

The findings were published online this week (Sept. 29) in Nature Nanotechnology.

Chemists and educators teach and use chemical reaction networks, a century-old language of equations that describes how mixtures of chemicals behave. The UW engineers take this language a step further and use it to write programs that direct the movement of tailor-made molecules.

"We start from an abstract, mathematical description of a chemical system, and then use DNA to build the molecules that realize the desired dynamics," said corresponding author Georg Seelig, a UW assistant professor of electrical engineering and of computer science and engineering. "The vision is that eventually, you can use this technology to build general-purpose tools."

Currently, when a biologist or chemist makes a certain type of molecular network, the engineering process is complex, cumbersome and hard to repurpose for building other systems. The UW engineers wanted to create a framework that gives scientists more flexibility. Seelig likens this new approach to programming languages that tell a computer what to do.

"I think this is appealing because it allows you to solve more than one problem," Seelig said. "If you want a computer to do something else, you just reprogram it. This project is very similar in that we can tell chemistry what to do."

Humans and other organisms already have complex networks of nano-sized molecules that help to regulate cells and keep the body in check. Scientists now are finding ways to design synthetic systems that behave like biological ones with the hope that synthetic molecules could support the body's natural functions. To that end, a system is needed to create synthetic DNA molecules that vary according to their specific functions.

The new approach isn't ready to be applied in the medical field, but future uses could include using this framework to make molecules that self-assemble within cells and serve as "smart" sensors. These could be embedded in a cell, then programmed to detect abnormalities and respond as needed, perhaps by delivering drugs directly to those cells.

Seelig and colleague Eric Klavins, a UW associate professor of electrical engineering, recently received $2 million from the National Science Foundation as part of a national initiative to boost research in molecular programming. The new language will be used to support that larger initiative, Seelig said.

Co-authors of the paper are Yuan-Jyue Chen, a UW doctoral student in electrical engineering; David Soloveichik of the University of California, San Francisco; Niranjan Srinivas at the California Institute of Technology; and Neil Dalchau, Andrew Phillips and Luca Cardelli of Microsoft Research.

The research was funded by the National Science Foundation, the Burroughs Wellcome Fund and the National Centers for Systems Biology.

####

For more information, please click here

Contacts:
Michelle Ma

206-543-2580

Georg Seelig

Copyright © University of Washington

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

Download abstract:

Related News Press

News and information

Surfing a wake of light: Researchers observe and control light wakes for the first time July 6th, 2015

Tel Aviv/Tsinghua University project uses crowd computing to improve water filtration: The research, a product of the new TAU-Tsinghua XIN Center, was conducted by 150,000 volunteers at IBM's World Community Grid July 6th, 2015

Transition from 3 to 2 dimensions increases conduction, MIPT scientists discover July 6th, 2015

A Stretchy Mesh Heater for Sore Muscles July 6th, 2015

Govt.-Legislation/Regulation/Funding/Policy

Surfing a wake of light: Researchers observe and control light wakes for the first time July 6th, 2015

New technology using silver may hold key to electronics advances July 2nd, 2015

NIST Group Maps Distribution of Carbon Nanotubes in Composite Materials July 2nd, 2015

Ultra-stable JILA microscopy technique tracks tiny objects for hours July 1st, 2015

Chip Technology

Fundamental observation of spin-controlled electrical conduction in metals: Ultrafast terahertz spectroscopy yields direct insight into the building block of modern magnetic memories July 6th, 2015

Transition from 3 to 2 dimensions increases conduction, MIPT scientists discover July 6th, 2015

Nanometrics to Announce Second Quarter Financial Results on July 23, 2015 July 2nd, 2015

The quantum middle man July 2nd, 2015

Self Assembly

Groundbreaking research to help control liquids at micro and nano scales July 3rd, 2015

New conductive ink for electronic apparel June 25th, 2015

Giving atoms their marching orders: Highly homogeneous nanotube enforces single-file flow of atoms in gas diffusion. Direct comparison of single-file and Fickian diffusion possible with new system described by researchers at the University of South Carolina and University of Flor June 24th, 2015

n-tech Research Issues Report on Smart Coatings Market, Free Download Available on Firm’s Website June 24th, 2015

Nanomedicine

A Stretchy Mesh Heater for Sore Muscles July 6th, 2015

New Biosensor Produced in Iran to Detect Effective Drugs in Cancer Treatment July 4th, 2015

Groundbreaking research to help control liquids at micro and nano scales July 3rd, 2015

Iranian Scientists Find Simple, Economic Method to Synthesize Antibacterial Nanoparticles July 2nd, 2015

Sensors

New Biosensor Produced in Iran to Detect Effective Drugs in Cancer Treatment July 4th, 2015

Groundbreaking research to help control liquids at micro and nano scales July 3rd, 2015

New micro-supercapacitor structure inspired by the intricate design of leaves: A team of scientists in Korea has devised a new method for making a graphene film for supercapacitors July 2nd, 2015

Carnegie Mellon chemists characterize 3-D macroporous hydrogels: Methods will allow researchers to develop new 'smart' materials June 30th, 2015

Discoveries

Fundamental observation of spin-controlled electrical conduction in metals: Ultrafast terahertz spectroscopy yields direct insight into the building block of modern magnetic memories July 6th, 2015

Surfing a wake of light: Researchers observe and control light wakes for the first time July 6th, 2015

Transition from 3 to 2 dimensions increases conduction, MIPT scientists discover July 6th, 2015

A Stretchy Mesh Heater for Sore Muscles July 6th, 2015

Announcements

Surfing a wake of light: Researchers observe and control light wakes for the first time July 6th, 2015

Tel Aviv/Tsinghua University project uses crowd computing to improve water filtration: The research, a product of the new TAU-Tsinghua XIN Center, was conducted by 150,000 volunteers at IBM's World Community Grid July 6th, 2015

Transition from 3 to 2 dimensions increases conduction, MIPT scientists discover July 6th, 2015

A Stretchy Mesh Heater for Sore Muscles July 6th, 2015

Interviews/Book Reviews/Essays/Reports/Podcasts/Journals/White papers

Fundamental observation of spin-controlled electrical conduction in metals: Ultrafast terahertz spectroscopy yields direct insight into the building block of modern magnetic memories July 6th, 2015

Surfing a wake of light: Researchers observe and control light wakes for the first time July 6th, 2015

Tel Aviv/Tsinghua University project uses crowd computing to improve water filtration: The research, a product of the new TAU-Tsinghua XIN Center, was conducted by 150,000 volunteers at IBM's World Community Grid July 6th, 2015

Transition from 3 to 2 dimensions increases conduction, MIPT scientists discover July 6th, 2015

Grants/Awards/Scholarships/Gifts/Contests/Honors/Records

Pioneering Southampton scientist awarded prestigious physics medal July 3rd, 2015

Discovery of nanotubes offers new clues about cell-to-cell communication July 2nd, 2015

World’s 1st Full-Color, Flexible, Skin-Like Display Developed at UCF June 24th, 2015

Physicists fine-tune control of agile exotic materials: Tunable hybrid polaritons realized with graphene layer on hexagonal boron nitride June 24th, 2015

Nanobiotechnology

Groundbreaking research to help control liquids at micro and nano scales July 3rd, 2015

Engineering the world’s smallest nanocrystal July 2nd, 2015

Nanometric sensor designed to detect herbicides can help diagnose multiple sclerosis June 23rd, 2015

Newly-Developed Biosensor in Iran Detects Cocaine Addiction June 23rd, 2015

Research partnerships

Fundamental observation of spin-controlled electrical conduction in metals: Ultrafast terahertz spectroscopy yields direct insight into the building block of modern magnetic memories July 6th, 2015

Surfing a wake of light: Researchers observe and control light wakes for the first time July 6th, 2015

Tel Aviv/Tsinghua University project uses crowd computing to improve water filtration: The research, a product of the new TAU-Tsinghua XIN Center, was conducted by 150,000 volunteers at IBM's World Community Grid July 6th, 2015

Groundbreaking research to help control liquids at micro and nano scales July 3rd, 2015

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More










ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project