Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Nanoparticles Used for Targeted Delivery of Genetic Materials to Liver

Abstract:
Iranian pharmaceutical researchers succeeded in the production of modified nanoparticles that carry genetic materials to liver tissue; the carriers are virus-free and have high performance in gene transfer to liver.

Nanoparticles Used for Targeted Delivery of Genetic Materials to Liver

Tehran, Iran | Posted on September 26th, 2013

At the same time, the carriers are very slightly toxic. In case the carriers are tested successfully on animals and humans, they can be widely used in medical industries.

The aim of the research was to obtain polymeric nano-carriers with the ability to target liver tissue and to effectively transfer genetic material into hepatocytes cells. At the same time, the carriers should prevent the toxicity in liver cells because the polymers used in the production of nanoparticles cause toxicity in cells.

This plan helps the simultaneous target gene delivery to liver cells and it modifies the amount of positive charges on nanoparticles by bonding alkyl carboxylic chains. As a result, the toxicity of the polymers reduced and hydrophobic/hydrophilic balance of the polymer was modified, and the gene delivery capacity improved.

Results of the research showed that nanoparticles modified with 6-carbon chains containing galactose have the best ability to transfer gene to liver cells, to the extent that their ability is significantly higher than that of polyethylenimine 25000 Dalton, which is considered the gold standard in non-virus gene delivery. This effect shows that the amount of protein has increased noticeably in liver cells while no increase is observed in the cells that have not received the carrier. The difference proves the targeted delivery of nanoparticles to liver cells.

A part of the results of the research have been published in July 2012 in Gene Therapy & Molecular Biology, vol. 12, pp. 62-71.

####

For more information, please click here

Copyright © Fars News Agency

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Organic solar cells reach record efficiency, benchmark for commercialization April 23rd, 2018

Remote-control shoots laser at nano-gold to turn on cancer-killing immune cells April 20th, 2018

New qubit now works without breaks: A universal design for superconducting qubits has been created April 19th, 2018

Observing biological nanotransporters: Chemistry April 19th, 2018

Nanomedicine

Remote-control shoots laser at nano-gold to turn on cancer-killing immune cells April 20th, 2018

Observing biological nanotransporters: Chemistry April 19th, 2018

Nanobiotix Shows NBTXR3 Nanoparticles Can Stoke Anti-Tumor Immune Response April 17th, 2018

Tiny nanomachine successfully completes test drive: Researchers at the University of Bonn and the research institute Caesar build a one-wheeled vehicle out of DNA rings April 11th, 2018

Discoveries

Organic solar cells reach record efficiency, benchmark for commercialization April 23rd, 2018

Remote-control shoots laser at nano-gold to turn on cancer-killing immune cells April 20th, 2018

New qubit now works without breaks: A universal design for superconducting qubits has been created April 19th, 2018

Observing biological nanotransporters: Chemistry April 19th, 2018

Announcements

Organic solar cells reach record efficiency, benchmark for commercialization April 23rd, 2018

Remote-control shoots laser at nano-gold to turn on cancer-killing immune cells April 20th, 2018

New qubit now works without breaks: A universal design for superconducting qubits has been created April 19th, 2018

Observing biological nanotransporters: Chemistry April 19th, 2018

Interviews/Book Reviews/Essays/Reports/Podcasts/Journals/White papers

Organic solar cells reach record efficiency, benchmark for commercialization April 23rd, 2018

Remote-control shoots laser at nano-gold to turn on cancer-killing immune cells April 20th, 2018

New qubit now works without breaks: A universal design for superconducting qubits has been created April 19th, 2018

Observing biological nanotransporters: Chemistry April 19th, 2018

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project