Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Nanoparticles Used for Targeted Delivery of Genetic Materials to Liver

Abstract:
Iranian pharmaceutical researchers succeeded in the production of modified nanoparticles that carry genetic materials to liver tissue; the carriers are virus-free and have high performance in gene transfer to liver.

Nanoparticles Used for Targeted Delivery of Genetic Materials to Liver

Tehran, Iran | Posted on September 26th, 2013

At the same time, the carriers are very slightly toxic. In case the carriers are tested successfully on animals and humans, they can be widely used in medical industries.

The aim of the research was to obtain polymeric nano-carriers with the ability to target liver tissue and to effectively transfer genetic material into hepatocytes cells. At the same time, the carriers should prevent the toxicity in liver cells because the polymers used in the production of nanoparticles cause toxicity in cells.

This plan helps the simultaneous target gene delivery to liver cells and it modifies the amount of positive charges on nanoparticles by bonding alkyl carboxylic chains. As a result, the toxicity of the polymers reduced and hydrophobic/hydrophilic balance of the polymer was modified, and the gene delivery capacity improved.

Results of the research showed that nanoparticles modified with 6-carbon chains containing galactose have the best ability to transfer gene to liver cells, to the extent that their ability is significantly higher than that of polyethylenimine 25000 Dalton, which is considered the gold standard in non-virus gene delivery. This effect shows that the amount of protein has increased noticeably in liver cells while no increase is observed in the cells that have not received the carrier. The difference proves the targeted delivery of nanoparticles to liver cells.

A part of the results of the research have been published in July 2012 in Gene Therapy & Molecular Biology, vol. 12, pp. 62-71.

####

For more information, please click here

Copyright © Fars News Agency

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

DNA triggers shape-shifting in hydrogels, opening a new way to make 'soft robots' September 21st, 2017

Physicists develop new recipes for design of fast single-photon gun Physicists develop high-speed single-photon sources for quantum computers of the future September 21st, 2017

GLOBALFOUNDRIES Announces Availability of mmWave and RF/Analog on Leading FDX™ FD-SOI Technology Platform: Technology solution delivers ‘connected intelligence’ to next generation high-volume wireless and IoT applications with lower power and significantly reduced cost September 20th, 2017

GLOBALFOUNDRIES Announces Availability of Embedded MRAM on Leading 22FDX® FD-SOI Platform: Advanced embedded non-volatile memory solution delivers ‘connected intelligence’ by expanding SoC capabilities on the 22nm process node September 20th, 2017

Nanomedicine

Do titanium dioxide particles from orthopedic implants disrupt bone repair? September 16th, 2017

Arrowhead Hosts Investor & Analyst R&D Day to Introduce TRiM(TM) Platform and Lead RNAi-based Drug Candidates September 14th, 2017

Graphene based terahertz absorbers: Printable graphene inks enable ultrafast lasers in the terahertz range September 13th, 2017

Applications for the nanomedTAB are open until September 18th, 2017 September 13th, 2017

Discoveries

DNA triggers shape-shifting in hydrogels, opening a new way to make 'soft robots' September 21st, 2017

Physicists develop new recipes for design of fast single-photon gun Physicists develop high-speed single-photon sources for quantum computers of the future September 21st, 2017

Copper catalyst yields high efficiency CO2-to-fuels conversion: Berkeley Lab scientists discover critical role of nanoparticle transformation September 20th, 2017

Solar-to-fuel system recycles CO2 to make ethanol and ethylene: Berkeley Lab advance is first demonstration of efficient, light-powered production of fuel via artificial photosynthesis September 19th, 2017

Announcements

DNA triggers shape-shifting in hydrogels, opening a new way to make 'soft robots' September 21st, 2017

Physicists develop new recipes for design of fast single-photon gun Physicists develop high-speed single-photon sources for quantum computers of the future September 21st, 2017

GLOBALFOUNDRIES Introduces New 12nm FinFET Technology for High-Performance Applications September 20th, 2017

Copper catalyst yields high efficiency CO2-to-fuels conversion: Berkeley Lab scientists discover critical role of nanoparticle transformation September 20th, 2017

Interviews/Book Reviews/Essays/Reports/Podcasts/Journals/White papers

DNA triggers shape-shifting in hydrogels, opening a new way to make 'soft robots' September 21st, 2017

Physicists develop new recipes for design of fast single-photon gun Physicists develop high-speed single-photon sources for quantum computers of the future September 21st, 2017

Copper catalyst yields high efficiency CO2-to-fuels conversion: Berkeley Lab scientists discover critical role of nanoparticle transformation September 20th, 2017

Solar-to-fuel system recycles CO2 to make ethanol and ethylene: Berkeley Lab advance is first demonstration of efficient, light-powered production of fuel via artificial photosynthesis September 19th, 2017

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project