- About Us
- Career Center
- Nano-Social Network
- Nano Consulting
- My Account
Iranian pharmaceutical researchers succeeded in the production of modified nanoparticles that carry genetic materials to liver tissue; the carriers are virus-free and have high performance in gene transfer to liver.
At the same time, the carriers are very slightly toxic. In case the carriers are tested successfully on animals and humans, they can be widely used in medical industries.
The aim of the research was to obtain polymeric nano-carriers with the ability to target liver tissue and to effectively transfer genetic material into hepatocytes cells. At the same time, the carriers should prevent the toxicity in liver cells because the polymers used in the production of nanoparticles cause toxicity in cells.
This plan helps the simultaneous target gene delivery to liver cells and it modifies the amount of positive charges on nanoparticles by bonding alkyl carboxylic chains. As a result, the toxicity of the polymers reduced and hydrophobic/hydrophilic balance of the polymer was modified, and the gene delivery capacity improved.
Results of the research showed that nanoparticles modified with 6-carbon chains containing galactose have the best ability to transfer gene to liver cells, to the extent that their ability is significantly higher than that of polyethylenimine 25000 Dalton, which is considered the gold standard in non-virus gene delivery. This effect shows that the amount of protein has increased noticeably in liver cells while no increase is observed in the cells that have not received the carrier. The difference proves the targeted delivery of nanoparticles to liver cells.
A part of the results of the research have been published in July 2012 in Gene Therapy & Molecular Biology, vol. 12, pp. 62-71.
For more information, please click here
Copyright © Fars News AgencyIf you have a comment, please Contact us.
Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.
|Related News Press|
News and information
New chip makes testing for antibiotic-resistant bacteria faster, easier: Researchers at the University of Toronto design diagnostic chip to reduce testing time from days to one hour, allowing doctors to pick the right antibiotic the first time May 28th, 2015
Arrowhead to Present at Jefferies 2015 Healthcare Conference May 27th, 2015
Nanotechnology identifies brain tumor types through MRI 'virtual biopsy' in animal studies: If results are confirmed in humans, tumor cells could someday be diagnosed by MRI imaging and treated with tumor-specific IV injections; new NIH grant will fund future study May 27th, 2015
New technique speeds nanoMRI imaging: Multiplexing technique for nanoscale magnetic resonance imaging developed by researchers in Switzerland cuts normal scan time from two weeks to two days May 28th, 2015
Interviews/Book Reviews/Essays/Reports/Podcasts/Journals/White papers