Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > Nanoparticles Used for Targeted Delivery of Genetic Materials to Liver

Abstract:
Iranian pharmaceutical researchers succeeded in the production of modified nanoparticles that carry genetic materials to liver tissue; the carriers are virus-free and have high performance in gene transfer to liver.

Nanoparticles Used for Targeted Delivery of Genetic Materials to Liver

Tehran, Iran | Posted on September 26th, 2013

At the same time, the carriers are very slightly toxic. In case the carriers are tested successfully on animals and humans, they can be widely used in medical industries.

The aim of the research was to obtain polymeric nano-carriers with the ability to target liver tissue and to effectively transfer genetic material into hepatocytes cells. At the same time, the carriers should prevent the toxicity in liver cells because the polymers used in the production of nanoparticles cause toxicity in cells.

This plan helps the simultaneous target gene delivery to liver cells and it modifies the amount of positive charges on nanoparticles by bonding alkyl carboxylic chains. As a result, the toxicity of the polymers reduced and hydrophobic/hydrophilic balance of the polymer was modified, and the gene delivery capacity improved.

Results of the research showed that nanoparticles modified with 6-carbon chains containing galactose have the best ability to transfer gene to liver cells, to the extent that their ability is significantly higher than that of polyethylenimine 25000 Dalton, which is considered the gold standard in non-virus gene delivery. This effect shows that the amount of protein has increased noticeably in liver cells while no increase is observed in the cells that have not received the carrier. The difference proves the targeted delivery of nanoparticles to liver cells.

A part of the results of the research have been published in July 2012 in Gene Therapy & Molecular Biology, vol. 12, pp. 62-71.

####

For more information, please click here

Copyright © Fars News Agency

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Novel Rocket Design Flight Tested: New Rocket Propellant and Motor Design Offers High Performance and Safety October 23rd, 2014

MEMS & Sensors Technology Showcase: Finalists Announced for MEMS Executive Congress US 2014 October 23rd, 2014

Nanoparticle technology triples the production of biogas October 23rd, 2014

SUNY Polytechnic Institute Invites the Public to Attend its Popular Statewide 'NANOvember' Series of Outreach and Educational Events October 23rd, 2014

Nanomedicine

NYU Researchers Break Nano Barrier to Engineer the First Protein Microfiber October 23rd, 2014

Iranian Scientists Apply Nanotechnology to Produce Surgery Suture October 23rd, 2014

RF Heating of Magnetic Nanoparticles Improves the Thawing of Cryopreserved Biomaterials October 23rd, 2014

Bipolar Disorder Discovery at the Nano Level: Tiny structures found in brain synapses help scientists better understand disorder October 22nd, 2014

Discoveries

Iranian Scientists Apply Nanotechnology to Produce Surgery Suture October 23rd, 2014

Iranian, Malaysian Scientists Study Nanophotocatalysts for Water Purification October 23rd, 2014

Nanoparticle technology triples the production of biogas October 23rd, 2014

Strengthening thin-film bonds with ultrafast data collection October 23rd, 2014

Announcements

Nanoparticle technology triples the production of biogas October 23rd, 2014

SUNY Polytechnic Institute Invites the Public to Attend its Popular Statewide 'NANOvember' Series of Outreach and Educational Events October 23rd, 2014

Advancing thin film research with nanostructured AZO: Innovnano’s unique and cost-effective AZO sputtering targets for the production of transparent conducting oxides October 23rd, 2014

Strengthening thin-film bonds with ultrafast data collection October 23rd, 2014

Interviews/Book Reviews/Essays/Reports/Podcasts/Journals

NYU Researchers Break Nano Barrier to Engineer the First Protein Microfiber October 23rd, 2014

Iranian Scientists Apply Nanotechnology to Produce Surgery Suture October 23rd, 2014

Iranian, Malaysian Scientists Study Nanophotocatalysts for Water Purification October 23rd, 2014

Strengthening thin-film bonds with ultrafast data collection October 23rd, 2014

NanoNews-Digest
The latest news from around the world, FREE





  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE