Nanotechnology Now

Our NanoNews Digest Sponsors



Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > UCLA researchers' smartphone 'microscope' can detect a single virus, nanoparticles

OzcanNanoCamera
OzcanNanoCamera

Abstract:
Your smartphone now can see what the naked eye cannot: A single virus and bits of material less than one-thousandth of the width of a human hair.

UCLA researchers' smartphone 'microscope' can detect a single virus, nanoparticles

Los Angeles, CA | Posted on September 17th, 2013

Aydogan Ozcan, a professor of electrical engineering and bioengineering at the UCLA Henry Samueli School of Engineering and Applied Science, and his team have created a portable smartphone attachment that can be used to perform sophisticated field testing to detect viruses and bacteria without the need for bulky and expensive microscopes and lab equipment. The device weighs less than half a pound.

"This cellphone-based imaging platform could be used for specific and sensitive detection of sub-wavelength objects, including bacteria and viruses and therefore could enable the practice of nanotechnology and biomedical testing in field settings and even in remote and resource-limited environments," Ozcan said. "These results also constitute the first time that single nanoparticles and viruses have been detected using a cellphone-based, field-portable imaging system."

The new research, published on Sept. 9 in the American Chemical Society's journal ACS Nano, comes on the heels of Ozcan's other recent inventions, including a cellphone camera-enabled sensor for allergens in food products and a smart phone attachment that can conduct common kidney tests.

Capturing clear images of objects as tiny as a single virus or a nanoparticle is difficult because the optical signal strength and contrast are very low for objects that are smaller than the wavelength of light.

In the ACS Nano paper, Ozcan details a fluorescent microscope device fabricated by a 3-D printer that contains a color filter, an external lens and a laser diode. The diode illuminates fluid or solid samples at a steep angle of roughly 75 degrees. This oblique illumination avoids detection of scattered light that would otherwise interfere with the intended fluorescent image.

Using this device, which attaches directly to the camera module on a smartphone, Ozcan's team was able to detect single human cytomegalovirus (HCMV) particles. HCMV is a common virus that can cause birth defects such as deafness and brain damage and can hasten the death of adults who have received organ implants, who are infected with the HIV virus or whose immune systems otherwise have been weakened. A single HCMV particle measures about 150-300 nanometers; a human hair is roughly 100,000 nanometers thick.

In a separate experiment, Ozcan's team also detected nanoparticles — specially marked fluorescent beads made of polystyrene — as small as 90-100 nanometers.

To verify these results, researchers in Ozcan's lab used other imaging devices, including a scanning electron microscope and a photon-counting confocal microscope. These experiments confirmed the findings made using the new cellphone-based imaging device.

Ozcan is the principal investigator on the research. The first author of ACS Nano the paper is Qingshan Wei, a postdoctoral researcher in Ozcan's lab and at UCLA's California NanoSystems Institute (CNSI), where Ozcan is associate director. Other co-authors include Hangfei Qi and Ting-Ting Wu of the UCLA Department of Molecular and Medical Pharmacology; Wei Luo, Derek Tseng, Zhe Wan and Zoltan Gorocs of the UCLA Electrical Engineering Department; So Jung Ki of the UCLA Department of Chemistry and Biochemistry; Laurent Bentolila of CNSI and the UCLA Department of Chemistry and Biochemistry; and Ren Sun of the UCLA Department of Molecular and Medical Pharmacology and CNSI.

Funding support for the Ozcan Research Group comes from Nokia University Research Funding, the Army Research Office, the National Science Foundation, the National Institutes of Health, the Office of Naval Research and the Presidential Early Career Award for Scientists and Engineers.

####

About University of California - Los Angeles
The UCLA Henry Samueli School of Engineering and Applied Science, established in 1945, offers 28 academic and professional degree programs and has an enrollment of more than 5,000 students. The school's distinguished faculty are leading research to address many of the critical challenges of the 21st century, including renewable energy, clean water, health care, wireless sensing and networking, and cyber-security. Ranked among the top 10 engineering schools at public universities nationwide, the school is home to eight multimillion-dollar interdisciplinary research centers in wireless sensor systems, wireless health, nanoelectronics, nanomedicine, renewable energy, customized computing, the smart grid, and the Internet, all funded by federal and private agencies and individual donors.

For more news, visit the UCLA Newsroom and follow us on Twitter.

For more information, please click here

Contacts:
Bill Kisliuk

310-206-0540

Copyright © University of California - Los Angeles

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

For more information on the Ozcan Research Group, visit org.ee.ucla.edu/ Ozcan is a founder of the mobile microanalysis startup company Holomic LLC, which seeks to commercialize imaging and sensing technologies licensed from the UCLA Office of Intellectual Property and Industry Sponsored Research.

Related News Press

News and information

3rd Iran-Proposed Nano Standard Approved by International Standard Organization November 22nd, 2014

NMTI announces breakthrough solutions for HAMR nanoantenna for next-generation ultra-high density magnetic storage November 21st, 2014

Sustainable Nanotechnologies Project November 20th, 2014

Quantum mechanical calculations reveal the hidden states of enzyme active sites November 20th, 2014

Imaging

Leica Microsystems Presents Universal Hybrid Detector for Single Molecule Detection and Imaging at SfN and ASCB: Leica HyD SMD - the Optimal Detector for Precise and Reliable SMD data November 20th, 2014

NRL Scientists Discover Novel Metamaterial Properties within Hexagonal Boron Nitride November 20th, 2014

Spectral Surface Mapping with Microscopic Resolution: CRAIC Technologies introduces Spectral Surface Mapping™ (S2M™) software November 18th, 2014

Two sensors in one: Nanoparticles that enable both MRI and fluorescent imaging could monitor cancer, other diseases November 18th, 2014

Govt.-Legislation/Regulation/Funding/Policy

3rd Iran-Proposed Nano Standard Approved by International Standard Organization November 22nd, 2014

NMTI announces breakthrough solutions for HAMR nanoantenna for next-generation ultra-high density magnetic storage November 21st, 2014

Sustainable Nanotechnologies Project November 20th, 2014

Quantum mechanical calculations reveal the hidden states of enzyme active sites November 20th, 2014

Discoveries

NMTI announces breakthrough solutions for HAMR nanoantenna for next-generation ultra-high density magnetic storage November 21st, 2014

UO-industry collaboration points to improved nanomaterials: University of Oregon microscope puts spotlight on the surface structure of quantum dots for designing new solar devices November 20th, 2014

Silver Nanoparticles Produced in Iran from Forest Plants Extract November 20th, 2014

Nano Sorbents Able to Remove Pollutions Caused by Oil Derivatives November 20th, 2014

Announcements

3rd Iran-Proposed Nano Standard Approved by International Standard Organization November 22nd, 2014

NMTI announces breakthrough solutions for HAMR nanoantenna for next-generation ultra-high density magnetic storage November 21st, 2014

Silver Nanoparticles Produced in Iran from Forest Plants Extract November 20th, 2014

Nano Sorbents Able to Remove Pollutions Caused by Oil Derivatives November 20th, 2014

Interviews/Book Reviews/Essays/Reports/Podcasts/Journals/White papers

NMTI announces breakthrough solutions for HAMR nanoantenna for next-generation ultra-high density magnetic storage November 21st, 2014

UO-industry collaboration points to improved nanomaterials: University of Oregon microscope puts spotlight on the surface structure of quantum dots for designing new solar devices November 20th, 2014

Silver Nanoparticles Produced in Iran from Forest Plants Extract November 20th, 2014

Nano Sorbents Able to Remove Pollutions Caused by Oil Derivatives November 20th, 2014

Tools

Leica Microsystems Presents Universal Hybrid Detector for Single Molecule Detection and Imaging at SfN and ASCB: Leica HyD SMD - the Optimal Detector for Precise and Reliable SMD data November 20th, 2014

Nanometrics Announces Upcoming Investor Events November 19th, 2014

Two sensors in one: Nanoparticles that enable both MRI and fluorescent imaging could monitor cancer, other diseases November 18th, 2014

Field-emission plug-and-play solution for microwave electron guns: To simplify the electron emission mechanism involved in microwave electron guns, a team of researchers has created and demonstrated a field-emission plug-and-play solution based on ultrananocrystalline diamond November 18th, 2014

Patents/IP/Tech Transfer/Licensing

Dicerna Announces License Agreement with Tekmira to Advance Dicerna’s PH1 Development Program November 17th, 2014

First genetic-based tool to detect circulating cancer cells in blood: NanoFlares light up individual cells if breast cancer biomarker is present November 17th, 2014

Ki-Bum Lee Patents Technology To Advance Stem Cell Therapeutics November 13th, 2014

'Direct writing' of diamond patterns from graphite a potential technological leap November 5th, 2014

Military

NRL Scientists Discover Novel Metamaterial Properties within Hexagonal Boron Nitride November 20th, 2014

Two sensors in one: Nanoparticles that enable both MRI and fluorescent imaging could monitor cancer, other diseases November 18th, 2014

Researchers create & control spin waves, lifting prospects for enhanced info processing November 17th, 2014

Penn engineers efficiently 'mix' light at the nanoscale November 17th, 2014

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More












ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE