Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > DNA 'cages' may aid drug delivery: Researchers find nanostructures made of DNA strands can encapsulate, release small-molecule drugs

A DNA cage (at left), with lipid-like molecules (in blue). The lipids come together in a "handshake" within the cage (center image) to encapsulate small-molecule drugs (purple). The molecules are released (at right) in response to the presence of a specific nucleic acid.

Credit: Thomas Edwardson, McGill University
A DNA cage (at left), with lipid-like molecules (in blue). The lipids come together in a "handshake" within the cage (center image) to encapsulate small-molecule drugs (purple). The molecules are released (at right) in response to the presence of a specific nucleic acid.

Credit: Thomas Edwardson, McGill University

Abstract:
Nanoscale "cages" made from strands of DNA can encapsulate small-molecule drugs and release them in response to a specific stimulus, McGill University researchers report in a new study.

DNA 'cages' may aid drug delivery: Researchers find nanostructures made of DNA strands can encapsulate, release small-molecule drugs

Montreal, Canada | Posted on September 2nd, 2013

The research, published online Sept. 1 in Nature Chemistry, marks a step toward the use of biological nanostructures to deliver drugs to diseased cells in patients. The findings could also open up new possibilities for designing DNA-based nanomaterials.

"This research is important for drug delivery, but also for fundamental structural biology and nanotechnology," says McGill Chemistry professor Hanadi Sleiman, who led the research team.

DNA carries the genetic information of all living organisms from one generation to the next. But strands of the material can also be used to build nanometre-scale structures. (A nanometre is one billionth of a metre - roughly one-100,000th the diameter of a human hair.)

In their experiments, the McGill researchers first created DNA cubes using short DNA strands, and modified them with lipid-like molecules. The lipids can act like sticky patches that come together and engage in a "handshake" inside the DNA cube, creating a core that can hold cargo such as drug molecules.

The McGill researchers also found that when the sticky patches were placed on one of the outside faces of the DNA cubes, two cubes could attach together. This new mode of assembly has similarities to the way that proteins fold into their functional structures, Sleiman notes. "It opens up a range of new possibilities for designing DNA-based nanomaterials."

Sleiman's lab has previously demonstrated that gold nanoparticles can be loaded and released from DNA nanotubes, providing a preliminary proof of concept that drug delivery might be possible. But the new study marks the first time that small molecules -- which are considerably smaller than the gold nanoparticles -- have been manipulated in such a way using a DNA nanostructure, the researchers report.

DNA nanostructures have several potential advantages over the synthetic materials often used to deliver drugs within the body, says Thomas Edwardson, a McGill doctoral student and co-author of the new paper. "DNA structures can be built with great precision, they are biodegradable and their size, shape and properties can be easily tuned".

The DNA cages can be made to release drugs in the presence of a specific nucleic acid sequence. "Many diseased cells, such as cancer cells, overexpress certain genes," Edwardson adds. "In a future application, one can imagine a DNA cube that carries drug cargo to the diseased cell environment, which will trigger the release of the drug." The Sleiman group is now conducting cell and animal studies to assess the viability of this method on chronic lymphocytic leukemia (CLL) and prostate cancer, in collaboration with researchers at the Lady Davis Institute for Medical Research at Montreal's Jewish General Hospital.

Funding for the Sleiman team's research was provided by the Natural Sciences and Engineering Research Council of Canada (NSERC), a CIHR Drug Development Training Program scholarship to Mr. Edwardson, the Canada Foundation for Innovation (CFI), the Centre for Self- Assembled Chemical Structures (CSACS) and the Canadian Institute for Advanced Research (CIFAR).

####

For more information, please click here

Contacts:
Chris Chipello

514-398-4201

Copyright © McGill University

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

The National Space Society Pays Tribute to Dr. Kalam -- One Of Our Leading Lights Has Joined The Stars August 1st, 2015

Nanocellulose Market 2015 - Global Industry Survey, Analysis, Size, Share, Outlook and Forecast to 2020 July 31st, 2015

Heating and cooling with light leads to ultrafast DNA diagnostics July 31st, 2015

Theoretical Physicists at Freie Universitšt Berlin Develop New Insights into Interface between Classical and Quantum Worlds July 31st, 2015

Govt.-Legislation/Regulation/Funding/Policy

Heating and cooling with light leads to ultrafast DNA diagnostics July 31st, 2015

Theoretical Physicists at Freie Universitšt Berlin Develop New Insights into Interface between Classical and Quantum Worlds July 31st, 2015

European Technology Platform for Nanomedicine and ENATRANS European Consortium Launch the 2nd edition of the Nanomedicine Award: The Award to be presented at BIO-Europe conference in Munich, November 2015 July 30th, 2015

Take a trip through the brain July 30th, 2015

Nanomedicine

Heating and cooling with light leads to ultrafast DNA diagnostics July 31st, 2015

European Technology Platform for Nanomedicine and ENATRANS European Consortium Launch the 2nd edition of the Nanomedicine Award: The Award to be presented at BIO-Europe conference in Munich, November 2015 July 30th, 2015

Take a trip through the brain July 30th, 2015

Sol-gel capacitor dielectric offers record-high energy storage July 30th, 2015

Discoveries

Heating and cooling with light leads to ultrafast DNA diagnostics July 31st, 2015

Theoretical Physicists at Freie Universitšt Berlin Develop New Insights into Interface between Classical and Quantum Worlds July 31st, 2015

Sol-gel capacitor dielectric offers record-high energy storage July 30th, 2015

Controlling Dynamic Behavior of Carbon Nanosheets in Structures Made Possible July 30th, 2015

Announcements

The National Space Society Pays Tribute to Dr. Kalam -- One Of Our Leading Lights Has Joined The Stars August 1st, 2015

Nanocellulose Market 2015 - Global Industry Survey, Analysis, Size, Share, Outlook and Forecast to 2020 July 31st, 2015

Heating and cooling with light leads to ultrafast DNA diagnostics July 31st, 2015

Theoretical Physicists at Freie Universitšt Berlin Develop New Insights into Interface between Classical and Quantum Worlds July 31st, 2015

Interviews/Book Reviews/Essays/Reports/Podcasts/Journals/White papers

Self-Healing Nano Anti-rust Coatings Market 2015 - Global Industry Survey, Analysis, Size, Share, Outlook and Forecast to 2020 July 31st, 2015

Nano Spray Instrument Market 2015 - Global Industry Survey, Analysis, Size, Share, Outlook and Forecast to 2020 July 31st, 2015

Nanocellulose Market 2015 - Global Industry Survey, Analysis, Size, Share, Outlook and Forecast to 2020 July 31st, 2015

Heating and cooling with light leads to ultrafast DNA diagnostics July 31st, 2015

Grants/Awards/Scholarships/Gifts/Contests/Honors/Records

Heating and cooling with light leads to ultrafast DNA diagnostics July 31st, 2015

Springer and Tsinghua University Press present the second Nano Research Award: Paul Alivisatos of the University of California Berkeley receives the honor for outstanding contributions in nanoscience July 30th, 2015

European Technology Platform for Nanomedicine and ENATRANS European Consortium Launch the 2nd edition of the Nanomedicine Award: The Award to be presented at BIO-Europe conference in Munich, November 2015 July 30th, 2015

Publication on Atomic Force Microscopy based nanoscale IR Spectroscopy (AFM-IR) persists as a 2015 top downloaded paper July 29th, 2015

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project