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A set of application notes from Malvern Instruments demonstrates the sample integrity, flexibility and lack of cross contamination during automated, rapid screening of protein samples using the Zetasizer Auto Plate Sampler (APS) dynamic light scattering (DLS) system. Enabling automated measurements of multiple samples, the Zetasizer APS delivers the same high sensitivity, high specification DLS measurements as other systems in Malvern's well-known Zetasizer series, making it ideal for protein applications. Easy data interpretation, using custom-designed results criteria, is supported by a colour-coded data quality display.
Zetasizer APS allows the production of large amounts of high quality DLS data with no user intervention to maximize productivity in busy protein laboratories. The data display capability enables the operator to easily retrieve results of interest, without having to manually scan through all measurements. Additionally, a new plate navigator feature acts as a data mapping tool, allowing for rapid screening of results to retrieve the information of most interest and the subsequent in-depth investigation of any single data set.
Setup and operation of the Zetasizer APS is straightforward and cleaning protocols ensure that no cross contamination occurs. The separate temperature controls of the plate holder and the measurement cell allow the Zetasizer APS to be used to maintain the protein samples in optimal condition until measurement. In addition, thermal trend measurements between 2°C to 90°C with 0.1°C degree precision can be defined. The plate scheduler allows the user to graphically set up size and thermal trend measurements of various samples from the same plate using a variety of different SOPs.
For further information about the Zetasizer APS, please visit: www.malvern.com/zetasizeraps
Malvern, Malvern Instruments and Zetasizer are registered trademarks of Malvern Instruments Ltd
About Malvern Instruments
Malvern provides the materials and biophysical characterization technology and expertise that enables scientists and engineers to understand and control the properties of dispersed systems. These systems range from proteins and polymers in solution, particle and nanoparticle suspensions and emulsions, through to sprays and aerosols, industrial bulk powders and high concentration slurries. Used at all stages of research, development and manufacturing, Malvern’s materials characterization instruments provide critical information that helps accelerate research and product development, enhance and maintain product quality and optimize process efficiency.
Our products reflect Malvern’s drive to exploit the latest technological innovations and our commitment to maximizing the potential of established techniques. They are used by both industry and academia, in sectors ranging from pharmaceuticals and biopharmaceuticals to bulk chemicals, cement, plastics and polymers, energy and the environment.
Malvern systems are used to measure particle size, particle shape, zeta potential, protein charge, molecular weight, mass, size and conformation, rheological properties and for chemical identification, advancing the understanding of dispersed systems across many different industries and applications.
Headquartered in Malvern, UK, Malvern Instruments has subsidiary organizations in all major European markets, North America, China, Japan and Korea, a joint venture in India, a global distributor network and applications laboratories around the world. www.malvern.com
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