Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Chemists Design ‘Smart’ Nanoparticles to Improve Drug Delivery, DNA Self-Assembly

Associate Professor Mathew M. Maye supervises graduate students Colleen Alexander, left, and Kristen Hamner in his chemistry lab.
Associate Professor Mathew M. Maye supervises graduate students Colleen Alexander, left, and Kristen Hamner in his chemistry lab.

Abstract:
A team of chemists in SU's College of Arts and Scientists has used a temperature-sensitive polymer to regulate DNA interactions in both a DNA-mediated assembly system and a DNA-encoded drug-delivery system.

Chemists Design ‘Smart’ Nanoparticles to Improve Drug Delivery, DNA Self-Assembly

Syracuse, NY | Posted on August 10th, 2013

Their findings, led by Associate Professor Mathew M. Maye and graduate students Kristen Hamner and Colleen Alexander, may improve how nanomaterials self-assemble into functional devices and how anticancer drugs, including doxorubicin, are delivered into the body. More information is available in a July 30 article in ACS Nano, published by the American Chemical Society.

One area of nanoscience that connects a range of fields—including optics, chemical sensing and drug delivery and treatment—is the self-assembly of nanoparticles. During self-assembly, the chemistry attached to the nanoparticle interface drives a reaction. As a result, particles come together to form a solid, a chai or a small molecule-like cluster.

Maye and others have recently figured out how to use DNA linkages to create an array of structures. The reactions are fast and stable, he says, but can also be problematic.

"For example, we want to know how to turn a reaction on and off, without tedious changes to the procedure," says Maye. "We've been addressing this problem by providing a thermal trigger in the form of a smart polymer, which changes its structure at the nano level."

A smart polymer is a large molecule, made up of many atomic units, that changes structure when exposed to external stimuli, such as light, acidity or temperature.

Maye and his colleagues have synthesized a designer polymer that not only reacts to temperature, but also may be assembled to a gold nanoparticle. The novelty of this approach, he says, is that the nanoparticle possesses short segments of single-stranded DNA.

"This multipurpose functionality and added 'smart' component are indicative of where nanoscience is going," says Maye. "We want nanomaterials to perform many tasks at once, and we want to be able to turn their interactions on and off remotely."

Maye's team, therefore, has designed a system in which a high temperature (e.g., 50 degrees Celsius) causes polymer strands to shrink, thereby exposing and making them operational, and a low temperature causes them to extend, blocking their DNA recognition properties.

Maye says that, in one test, self-assembly between complementary DNA nanoparticles occurred at only a high temperature. In a second study, his team found that heat triggered the release of doxorubicin at the DNA shell of the encoded nanocarrier.

Recently invented by Maye and his SU colleagues, the nanocarrier boasts a six-fold increase in toxicity, compared to ones used in previous studies.

"What's novel about this approach is that interparticle linkages are dynamic and reconfigurable," Maye says. "Such reconfiguration may lead to smart solids and metamaterials that react to environmental stimuli, much the same way smart polymers react in bulk."

Maye and his team have also employed a number of advanced techniques to better understand the mechanisms of their system, including dynamic light scattering and small-angle X-ray scattering.

"Being able to control nanoparticle assembly with temperature allows us to fine-tune their reactions and form more predictable structures. It also gives us a more improved system in which to scale assembly," he says.

Maye goes on to explain that for DNA-encoded nanoparticles, such classes of particles are an excellent platform for drug delivery: "When combined with thermosensitive polymers such as the ones in our system, they could become very lucrative."

In addition to Maye, Hamner and Alexander, the article was co-authored by students from two National Science Foundation (NSF) Research Experiences for Undergraduates programs—one in SU's chemistry department and the other in the Syracuse Biomaterials Institute—both of which are sponsored by the NSF.

Maye's work is supported by the Air Force Office of Scientific Research, as part of his Presidential Early Career Award for Scientists and Engineers. Additional support is provided by SBI and by SU's Forensic and National Security Sciences Institute. Maye's work has also made use of X-ray scattering equipment in the Cornell High Energy Synchrotron Source lab at Cornell University.

####

For more information, please click here

Contacts:
Rob Enslin

315-443-3403

Copyright © Syracuse University

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Arrowhead Pharmaceuticals to Host R&D Day on Emerging Pipeline of RNAi Therapeutics September 25th, 2018

Arrowhead Pharmaceuticals to Host R&D Day on Emerging Pipeline of RNAi Therapeutics September 25th, 2018

Arrowhead Pharmaceuticals Reports Inducement Grants under NASDAQ Marketplace Rule 5635(c)(4) September 25th, 2018

Viral RNA sensing: Optical detection of picomolar concentrations of RNA using switches in plasmonic chirality September 21st, 2018

Govt.-Legislation/Regulation/Funding/Policy

UT engineers develop first method for controlling nanomotors: Breakthrough for nanotechnology as UT engineers develop first method for switching the mechanical motion of nanomotors September 21st, 2018

Researchers develop microbubble scrubber to destroy dangerous biofilms September 19th, 2018

Researchers managed to prevent the disappearing of quantum information September 14th, 2018

New photonic chip promises more robust quantum computers September 14th, 2018

Self Assembly

DNA drives design principles for lighter, thinner optical displays: Lighter gold nanoparticles could replace thicker, heavier layered polymers used in displays’ back-reflectors June 27th, 2018

Collaboration yields discovery of 12-sided silica cages June 20th, 2018

Self-assembling 3D battery would charge in seconds May 22nd, 2018

Engineered polymer membranes could be new option for water treatment May 6th, 2018

Nanomedicine

Arrowhead Pharmaceuticals to Host R&D Day on Emerging Pipeline of RNAi Therapeutics September 25th, 2018

Arrowhead Pharmaceuticals to Host R&D Day on Emerging Pipeline of RNAi Therapeutics September 25th, 2018

Arrowhead Pharmaceuticals Reports Inducement Grants under NASDAQ Marketplace Rule 5635(c)(4) September 25th, 2018

Viral RNA sensing: Optical detection of picomolar concentrations of RNA using switches in plasmonic chirality September 21st, 2018

Discoveries

Searching for errors in the quantum world September 21st, 2018

Viral RNA sensing: Optical detection of picomolar concentrations of RNA using switches in plasmonic chirality September 21st, 2018

UT engineers develop first method for controlling nanomotors: Breakthrough for nanotechnology as UT engineers develop first method for switching the mechanical motion of nanomotors September 21st, 2018

Silver nanoparticles are toxic for aquatic organisms: A research team at the UPV/EHU-University of the Basque Country has analysed how zebrafish are affected in the long term by exposure to silver particles September 19th, 2018

Announcements

Arrowhead Pharmaceuticals to Host R&D Day on Emerging Pipeline of RNAi Therapeutics September 25th, 2018

Arrowhead Pharmaceuticals to Host R&D Day on Emerging Pipeline of RNAi Therapeutics September 25th, 2018

Arrowhead Pharmaceuticals Reports Inducement Grants under NASDAQ Marketplace Rule 5635(c)(4) September 25th, 2018

Viral RNA sensing: Optical detection of picomolar concentrations of RNA using switches in plasmonic chirality September 21st, 2018

Interviews/Book Reviews/Essays/Reports/Podcasts/Journals/White papers

Searching for errors in the quantum world September 21st, 2018

Viral RNA sensing: Optical detection of picomolar concentrations of RNA using switches in plasmonic chirality September 21st, 2018

UT engineers develop first method for controlling nanomotors: Breakthrough for nanotechnology as UT engineers develop first method for switching the mechanical motion of nanomotors September 21st, 2018

NUS researchers invent new test kit for quick, accurate and low-cost screening of diseases: Test results are denoted by a color change and could be further analyzed by a smartphone app, making it attractive as a point-of-care diagnostic device September 19th, 2018

Military

Ultracold atoms used to verify 1963 prediction about 1D electrons: Rice University, University of Geneva study focuses on theory that's increasingly relevant to chipmakers September 5th, 2018

Neutrophil nanosponges soak up proteins that promote rheumatoid arthritis September 3rd, 2018

Virginia Tech researchers develop novel process to 3D print one of the strongest materials on Earth August 23rd, 2018

Biomimetic micro/nanoscale fiber reinforced composites August 10th, 2018

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project