Nanotechnology Now





Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > Chemists Design ‘Smart’ Nanoparticles to Improve Drug Delivery, DNA Self-Assembly

Associate Professor Mathew M. Maye supervises graduate students Colleen Alexander, left, and Kristen Hamner in his chemistry lab.
Associate Professor Mathew M. Maye supervises graduate students Colleen Alexander, left, and Kristen Hamner in his chemistry lab.

Abstract:
A team of chemists in SU's College of Arts and Scientists has used a temperature-sensitive polymer to regulate DNA interactions in both a DNA-mediated assembly system and a DNA-encoded drug-delivery system.

Chemists Design ‘Smart’ Nanoparticles to Improve Drug Delivery, DNA Self-Assembly

Syracuse, NY | Posted on August 10th, 2013

Their findings, led by Associate Professor Mathew M. Maye and graduate students Kristen Hamner and Colleen Alexander, may improve how nanomaterials self-assemble into functional devices and how anticancer drugs, including doxorubicin, are delivered into the body. More information is available in a July 30 article in ACS Nano, published by the American Chemical Society.

One area of nanoscience that connects a range of fields—including optics, chemical sensing and drug delivery and treatment—is the self-assembly of nanoparticles. During self-assembly, the chemistry attached to the nanoparticle interface drives a reaction. As a result, particles come together to form a solid, a chai or a small molecule-like cluster.

Maye and others have recently figured out how to use DNA linkages to create an array of structures. The reactions are fast and stable, he says, but can also be problematic.

"For example, we want to know how to turn a reaction on and off, without tedious changes to the procedure," says Maye. "We've been addressing this problem by providing a thermal trigger in the form of a smart polymer, which changes its structure at the nano level."

A smart polymer is a large molecule, made up of many atomic units, that changes structure when exposed to external stimuli, such as light, acidity or temperature.

Maye and his colleagues have synthesized a designer polymer that not only reacts to temperature, but also may be assembled to a gold nanoparticle. The novelty of this approach, he says, is that the nanoparticle possesses short segments of single-stranded DNA.

"This multipurpose functionality and added 'smart' component are indicative of where nanoscience is going," says Maye. "We want nanomaterials to perform many tasks at once, and we want to be able to turn their interactions on and off remotely."

Maye's team, therefore, has designed a system in which a high temperature (e.g., 50 degrees Celsius) causes polymer strands to shrink, thereby exposing and making them operational, and a low temperature causes them to extend, blocking their DNA recognition properties.

Maye says that, in one test, self-assembly between complementary DNA nanoparticles occurred at only a high temperature. In a second study, his team found that heat triggered the release of doxorubicin at the DNA shell of the encoded nanocarrier.

Recently invented by Maye and his SU colleagues, the nanocarrier boasts a six-fold increase in toxicity, compared to ones used in previous studies.

"What's novel about this approach is that interparticle linkages are dynamic and reconfigurable," Maye says. "Such reconfiguration may lead to smart solids and metamaterials that react to environmental stimuli, much the same way smart polymers react in bulk."

Maye and his team have also employed a number of advanced techniques to better understand the mechanisms of their system, including dynamic light scattering and small-angle X-ray scattering.

"Being able to control nanoparticle assembly with temperature allows us to fine-tune their reactions and form more predictable structures. It also gives us a more improved system in which to scale assembly," he says.

Maye goes on to explain that for DNA-encoded nanoparticles, such classes of particles are an excellent platform for drug delivery: "When combined with thermosensitive polymers such as the ones in our system, they could become very lucrative."

In addition to Maye, Hamner and Alexander, the article was co-authored by students from two National Science Foundation (NSF) Research Experiences for Undergraduates programs—one in SU's chemistry department and the other in the Syracuse Biomaterials Institute—both of which are sponsored by the NSF.

Maye's work is supported by the Air Force Office of Scientific Research, as part of his Presidential Early Career Award for Scientists and Engineers. Additional support is provided by SBI and by SU's Forensic and National Security Sciences Institute. Maye's work has also made use of X-ray scattering equipment in the Cornell High Energy Synchrotron Source lab at Cornell University.

####

For more information, please click here

Contacts:
Rob Enslin

315-443-3403

Copyright © Syracuse University

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

TCL Unveils First 65” TV Featuring QD Vision’s Color IQ™ Quantum Dot Technology: Emerging industry leader introduces expanded quantum dot TV lineup May 30th, 2015

Nanotech Secures Additional Patents in Advanced Security Features: New patented features gain attention from the banknote industry May 30th, 2015

New 'designer carbon' from Stanford boosts battery performance May 30th, 2015

Two UCSB Professors Receive Early Career Research Awards: The Department of Energy’s award for young scientists acknowledges UC Santa Barbara’s standing as a top tier research institution May 29th, 2015

Govt.-Legislation/Regulation/Funding/Policy

OSU researchers prove magnetism can control heat, sound: Team leverages OSC services to help confirm, interpret experimental findings May 29th, 2015

Physicists precisely measure interaction between atoms and carbon surfaces May 28th, 2015

Linking superconductivity and structure May 28th, 2015

Chemists discover key reaction mechanism behind the highly touted sodium-oxygen battery May 28th, 2015

Self Assembly

Engineering Phase Changes in Nanoparticle Arrays: Scientists alter attractive and repulsive forces between DNA-linked particles to make dynamic, phase-shifting forms of nanomaterials May 25th, 2015

Scientists Use Nanoscale Building Blocks and DNA 'Glue' to Shape 3D Superlattices: New approach to designing ordered composite materials for possible energy applications April 23rd, 2015

Advances in molecular electronics: Lights on -- molecule on: Researchers from Dresden and Konstanz succeed in light-controlled molecule switching April 20th, 2015

Carnegie Mellon chemists create tiny gold nanoparticles that reflect nature's patterns April 9th, 2015

Nanomedicine

New chip makes testing for antibiotic-resistant bacteria faster, easier: Researchers at the University of Toronto design diagnostic chip to reduce testing time from days to one hour, allowing doctors to pick the right antibiotic the first time May 28th, 2015

New electronic stent could provide feedback and therapy — then dissolve May 27th, 2015

Arrowhead to Present at Jefferies 2015 Healthcare Conference May 27th, 2015

Nanotechnology identifies brain tumor types through MRI 'virtual biopsy' in animal studies: If results are confirmed in humans, tumor cells could someday be diagnosed by MRI imaging and treated with tumor-specific IV injections; new NIH grant will fund future study May 27th, 2015

Discoveries

Stanford breakthrough heralds super-efficient light-based computers: Light can transmit more data while consuming far less power than electricity, and an engineering feat brings optical data transport closer to replacing wires May 29th, 2015

Donuts, math, and superdense teleportation of quantum information May 29th, 2015

OSU researchers prove magnetism can control heat, sound: Team leverages OSC services to help confirm, interpret experimental findings May 29th, 2015

New chip makes testing for antibiotic-resistant bacteria faster, easier: Researchers at the University of Toronto design diagnostic chip to reduce testing time from days to one hour, allowing doctors to pick the right antibiotic the first time May 28th, 2015

Announcements

TCL Unveils First 65” TV Featuring QD Vision’s Color IQ™ Quantum Dot Technology: Emerging industry leader introduces expanded quantum dot TV lineup May 30th, 2015

Nanotech Secures Additional Patents in Advanced Security Features: New patented features gain attention from the banknote industry May 30th, 2015

New 'designer carbon' from Stanford boosts battery performance May 30th, 2015

Two UCSB Professors Receive Early Career Research Awards: The Department of Energy’s award for young scientists acknowledges UC Santa Barbara’s standing as a top tier research institution May 29th, 2015

Interviews/Book Reviews/Essays/Reports/Podcasts/Journals/White papers

New 'designer carbon' from Stanford boosts battery performance May 30th, 2015

Stanford breakthrough heralds super-efficient light-based computers: Light can transmit more data while consuming far less power than electricity, and an engineering feat brings optical data transport closer to replacing wires May 29th, 2015

Donuts, math, and superdense teleportation of quantum information May 29th, 2015

OSU researchers prove magnetism can control heat, sound: Team leverages OSC services to help confirm, interpret experimental findings May 29th, 2015

Military

OSU researchers prove magnetism can control heat, sound: Team leverages OSC services to help confirm, interpret experimental findings May 29th, 2015

Linking superconductivity and structure May 28th, 2015

This Slinky lookalike 'hyperlens' helps us see tiny objects: The photonics advancement could improve early cancer detection, nanoelectronics manufacturing and scientists' ability to observe single molecules May 23rd, 2015

New Antibacterial Wound Dressing in Iran Can Display Replacement Time May 22nd, 2015

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More










ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project