Nanotechnology Now







Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > Nanoparticles Help Disrupt Tumor Blood Supply, Destroy Tumors

Abstract:
In recent years, cancer researchers have been developing agents that destroy the blood vessels surrounding tumors with the goal of starving tumors to death. Some of these agents, such as tumor necrosis factor-alpha (TNF-α) have shown promising results, but often their toxicity has proven too great to be clinically useful. Using gold nanoparticles as a delivery vehicle for TNF-α has reduced this toxicity and the resulting construct has already completed a phase I clinical trial in humans.

Nanoparticles Help Disrupt Tumor Blood Supply, Destroy Tumors

Bethesda, MD | Posted on July 15th, 2013

Now, a team at the University of Minnesota headed by John Bischof, has shown that they can use this gold nanoparticle-TNF-α system to enhance the effects of either thermal therapy or cryosurgery. Moreover, the researchers demonstrated that they can use standard magnetic resonance imaging technology to visualize tumor destruction. Dr. Bischof and his colleagues reported their findings in the journal Molecular Pharmaceutics.

Experiments in a mouse model of human prostate cancer showed that the gold nanoparticle-TNF-α system disrupted blood flow into tumors within 90 minutes of injection, an effect that lasted up to six hours. Using a technique known as dynamic contrast-enhanced MRI, Dr. Bischof's team was able to clearly image the changes in blood flow into and around the tumor following nanoparticle treatment. The researchers note that in human patients, a simple five-minute MRI scan would be sufficient to detect a meaningful change in tumor blood vessel function.

Once the tumor blood vessels had been "preconditioned," Dr. Bischof and his collaborators treated the animals with either thermal therapy or cryosurgery, both of which produced marked reductions in tumors. They noted that none of the animals treated with thermal therapy died, an important finding given that an equivalent dose of TNF-α with no gold nanoparticle attached followed by thermal therapy was found to be lethal in a large percentage of animals. The researchers also showed that nanoparticle-delivered TNF-α did not trigger inflammatory reactions associated with activated neutrophils, something that does occur when tumors are treated with native TNF-α.

####

About The National Cancer Institute (NCI)
To help meet the goal of reducing the burden of cancer, the National Cancer Institute (NCI), part of the National Institutes of Health, is engaged in efforts to harness the power of nanotechnology to radically change the way we diagnose, treat and prevent cancer.

The NCI Alliance for Nanotechnology in Cancer is a comprehensive, systematized initiative encompassing the public and private sectors, designed to accelerate the application of the best capabilities of nanotechnology to cancer.

Currently, scientists are limited in their ability to turn promising molecular discoveries into benefits for cancer patients. Nanotechnology can provide the technical power and tools that will enable those developing new diagnostics, therapeutics, and preventives to keep pace with today’s explosion in knowledge.

For more information, please click here

Contacts:
National Cancer Institute
Office of Technology & Industrial Relations
ATTN: NCI Alliance for Nanotechnology in Cancer
Building 31, Room 10A49
31 Center Drive , MSC 2580
Bethesda , MD 20892-2580

Copyright © The National Cancer Institute (NCI)

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

View abstract - "Nanoparticle delivered vascular disrupting agents (VDAs): use of TNF-alpha conjugated gold nanoparticles for multimodal cancer therapy."

Related News Press

News and information

Toyocolor to Launch New Carbon Nanotube Materials at nano tech 2015 January 24th, 2015

NANOPOSTER 2015 - 5th Virtual Nanotechnology Conference - call for abstracts January 24th, 2015

Nanosensor Used for Simultaneous Determination of Effective Tea Components January 24th, 2015

The latest fashion: Graphene edges can be tailor-made: Rice University theory shows it should be possible to tune material's properties January 24th, 2015

Govt.-Legislation/Regulation/Funding/Policy

The latest fashion: Graphene edges can be tailor-made: Rice University theory shows it should be possible to tune material's properties January 24th, 2015

Scientists 'bend' elastic waves with new metamaterials that could have commercial applications: Materials could benefit imaging and military enhancements such as elastic cloaking January 23rd, 2015

Harper Government Supports Research Innovation in Western Canada January 22nd, 2015

EnvisioNano: An image contest hosted by the National Nanotechnology Initiative (NNI) January 22nd, 2015

Nanomedicine

Teijin to Participate in Nano Tech 2015 January 22nd, 2015

2nd International Conference on Infectious Diseases & Nanomedicine (December 15-18, 2015, Kathmandu, NEPAL) January 22nd, 2015

Anti-microbial coatings with a long-term effect for surfaces – presentation at nano tech 2015 in Japan January 21st, 2015

A spoonful of sugar in silver nanoparticles to regulate their toxicity January 21st, 2015

Discoveries

Nanosensor Used for Simultaneous Determination of Effective Tea Components January 24th, 2015

The latest fashion: Graphene edges can be tailor-made: Rice University theory shows it should be possible to tune material's properties January 24th, 2015

Iranian Scientists Produce Graphene-Based Oxygen Sensor January 23rd, 2015

Silver nanowires demonstrate unexpected self-healing mechanism: The material has potential for flexible electronics January 23rd, 2015

Announcements

Toyocolor to Launch New Carbon Nanotube Materials at nano tech 2015 January 24th, 2015

NANOPOSTER 2015 - 5th Virtual Nanotechnology Conference - call for abstracts January 24th, 2015

Nanosensor Used for Simultaneous Determination of Effective Tea Components January 24th, 2015

The latest fashion: Graphene edges can be tailor-made: Rice University theory shows it should be possible to tune material's properties January 24th, 2015

Interviews/Book Reviews/Essays/Reports/Podcasts/Journals/White papers

Nanosensor Used for Simultaneous Determination of Effective Tea Components January 24th, 2015

New technique helps probe performance of organic solar cell materials January 23rd, 2015

Iranian Scientists Produce Graphene-Based Oxygen Sensor January 23rd, 2015

Silver nanowires demonstrate unexpected self-healing mechanism: The material has potential for flexible electronics January 23rd, 2015

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More










ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2015 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE