Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > Nanoparticles Utilized to Improve Cancer Treatment

Abstract:
Iranian researchers at Tarbiat Modarres University used nanoparticles containing anti-cancer medicine to produce a new targeted drug delivery system to deliver drug to the damaged tissue.

Nanoparticles Utilized to Improve Cancer Treatment

Tehran, Iran | Posted on June 29th, 2013

The new system can be used in the delivery of various drugs used in chemotherapy for cancer treatment.

In this research, albumin nanoparticles containing 5-fluouracil anti-cancer drug was produced firstly. Then, an anti-MUC1 monoclonal antibody entitled PR81 was attached covalently to the surface of the nanoparticles in order to effectively deliver the mentioned drug to the cancer cells. The attachment of antibody to the surface of nanoparticles containing drug enables the drug to carry the medicine specifically to cancer cells, and it minimizes the damage of the healthy tissues.

In this research, bovine serum albumin (BSA) nanoparticles containing 5-fluouracil medicine were synthesized through dissolubility method. Then, PR81 anti-MUC1 monoclonal antibody was attached to the albumin nanoparticles containing the medicine by using two-end active pegging attachment taking into consideration the free amine groups in the surface of nanoparticles and free sulfur groups created on the antibody structure.

Attachment of antibody and nanoparticles was confirmed by enzyme linked immunosorbant assay (ELISA) method. In-vitro evaluation of the synthesized target system on MCF7 cells showed the higher performance of the system in removing cells in comparison with the free drug. In addition, the system is able to conserve its physical, chemical, and biological stability for 20 days at room temperature.

Results of the research lead to the production and confirmation of a new drug delivery system based on albumin nanoparticles, which can be used for the delivery of various drugs used in chemotherapy for the treatment of cancer.

Results of the research have been published in detail in Human Antibodies, vol. 21, issue 3-4, 2012. For more information about the details of the research, study the full article on pages 49-56 on the same journal.

####

For more information, please click here

Copyright © Fars News Agency

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Iranian Researchers Present New Model to Strengthen Superconductivity at Higher Temperatures April 19th, 2014

Iranian Researchers Produce New Anti-Cancer Drug from Turmeric April 19th, 2014

'Exotic' material is like a switch when super thin April 18th, 2014

Innovative strategy to facilitate organ repair April 18th, 2014

Nanomedicine

Iranian Researchers Present New Model to Strengthen Superconductivity at Higher Temperatures April 19th, 2014

Iranian Researchers Produce New Anti-Cancer Drug from Turmeric April 19th, 2014

Innovative strategy to facilitate organ repair April 18th, 2014

High-temperature plasmonics eyed for solar, computer innovation April 17th, 2014

Discoveries

Iranian Researchers Present New Model to Strengthen Superconductivity at Higher Temperatures April 19th, 2014

Iranian Researchers Produce New Anti-Cancer Drug from Turmeric April 19th, 2014

'Exotic' material is like a switch when super thin April 18th, 2014

Innovative strategy to facilitate organ repair April 18th, 2014

Announcements

Iranian Researchers Present New Model to Strengthen Superconductivity at Higher Temperatures April 19th, 2014

Iranian Researchers Produce New Anti-Cancer Drug from Turmeric April 19th, 2014

'Exotic' material is like a switch when super thin April 18th, 2014

Innovative strategy to facilitate organ repair April 18th, 2014

Interviews/Book Reviews/Essays/Reports/Podcasts/Journals

Iranian Researchers Present New Model to Strengthen Superconductivity at Higher Temperatures April 19th, 2014

Iranian Researchers Produce New Anti-Cancer Drug from Turmeric April 19th, 2014

'Exotic' material is like a switch when super thin April 18th, 2014

Innovative strategy to facilitate organ repair April 18th, 2014

NanoNews-Digest
The latest news from around the world, FREE







  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE