Nanotechnology Now





Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > Nanoparticles Utilized to Improve Cancer Treatment

Abstract:
Iranian researchers at Tarbiat Modarres University used nanoparticles containing anti-cancer medicine to produce a new targeted drug delivery system to deliver drug to the damaged tissue.

Nanoparticles Utilized to Improve Cancer Treatment

Tehran, Iran | Posted on June 29th, 2013

The new system can be used in the delivery of various drugs used in chemotherapy for cancer treatment.

In this research, albumin nanoparticles containing 5-fluouracil anti-cancer drug was produced firstly. Then, an anti-MUC1 monoclonal antibody entitled PR81 was attached covalently to the surface of the nanoparticles in order to effectively deliver the mentioned drug to the cancer cells. The attachment of antibody to the surface of nanoparticles containing drug enables the drug to carry the medicine specifically to cancer cells, and it minimizes the damage of the healthy tissues.

In this research, bovine serum albumin (BSA) nanoparticles containing 5-fluouracil medicine were synthesized through dissolubility method. Then, PR81 anti-MUC1 monoclonal antibody was attached to the albumin nanoparticles containing the medicine by using two-end active pegging attachment taking into consideration the free amine groups in the surface of nanoparticles and free sulfur groups created on the antibody structure.

Attachment of antibody and nanoparticles was confirmed by enzyme linked immunosorbant assay (ELISA) method. In-vitro evaluation of the synthesized target system on MCF7 cells showed the higher performance of the system in removing cells in comparison with the free drug. In addition, the system is able to conserve its physical, chemical, and biological stability for 20 days at room temperature.

Results of the research lead to the production and confirmation of a new drug delivery system based on albumin nanoparticles, which can be used for the delivery of various drugs used in chemotherapy for the treatment of cancer.

Results of the research have been published in detail in Human Antibodies, vol. 21, issue 3-4, 2012. For more information about the details of the research, study the full article on pages 49-56 on the same journal.

####

For more information, please click here

Copyright © Fars News Agency

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Clues to inner atomic life from subtle light-emission shifts: Hyperfine structure of light absorption by short-lived cadmium atom isotopes reveals characteristics of the nucleus that matter for high precision detection methods July 3rd, 2015

Pioneering Southampton scientist awarded prestigious physics medal July 3rd, 2015

Groundbreaking research to help control liquids at micro and nano scales July 3rd, 2015

Discovery of nanotubes offers new clues about cell-to-cell communication July 2nd, 2015

Nanomedicine

Groundbreaking research to help control liquids at micro and nano scales July 3rd, 2015

Iranian Scientists Find Simple, Economic Method to Synthesize Antibacterial Nanoparticles July 2nd, 2015

Leti Announces Launch of First European Nanomedicine Characterisation Laboratory: Project Combines Expertise of 9 Partners in 8 Countries to Foster Nanomedicine Innovation and Facilitate Regulatory Approval July 1st, 2015

Chitosan coated, chemotherapy packed nanoparticles may target cancer stem cells June 30th, 2015

Discoveries

Clues to inner atomic life from subtle light-emission shifts: Hyperfine structure of light absorption by short-lived cadmium atom isotopes reveals characteristics of the nucleus that matter for high precision detection methods July 3rd, 2015

Groundbreaking research to help control liquids at micro and nano scales July 3rd, 2015

Producing spin-entangled electrons July 2nd, 2015

NIST Group Maps Distribution of Carbon Nanotubes in Composite Materials July 2nd, 2015

Announcements

Clues to inner atomic life from subtle light-emission shifts: Hyperfine structure of light absorption by short-lived cadmium atom isotopes reveals characteristics of the nucleus that matter for high precision detection methods July 3rd, 2015

Pioneering Southampton scientist awarded prestigious physics medal July 3rd, 2015

Groundbreaking research to help control liquids at micro and nano scales July 3rd, 2015

NIST Group Maps Distribution of Carbon Nanotubes in Composite Materials July 2nd, 2015

Interviews/Book Reviews/Essays/Reports/Podcasts/Journals/White papers

Clues to inner atomic life from subtle light-emission shifts: Hyperfine structure of light absorption by short-lived cadmium atom isotopes reveals characteristics of the nucleus that matter for high precision detection methods July 3rd, 2015

Pioneering Southampton scientist awarded prestigious physics medal July 3rd, 2015

Groundbreaking research to help control liquids at micro and nano scales July 3rd, 2015

NIST Group Maps Distribution of Carbon Nanotubes in Composite Materials July 2nd, 2015

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More










ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project