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Iranian researchers from the Institute for Advances Studies in Basic Sciences in Zanjan studied the axial potential of optical tweezers and succeeded in using this device for dynamometric purposes in experiments such as DNA tension and studying the mechanical properties of biocells.
The use of optical tweezers in order to measure the force in objects at nanometirc scale can be an interesting idea for the researchers in all fields, including biosciences. The use of the optical tweezers requires a comprehensive and exact understanding of its potential.
The main objective of this project is to study and identify the axial potential of optical tweezers and to use it in dynamometric experiments such as DNA tension and evaluation of chemical properties of biocells.
Among the applications of this device, mention can be made of dynamometry in experiments with fluid environment at micro or nanometric scales and studying the mechanical properties of biocells.
Dynamometric experiments such as DNA tension, RNA, and other biopolymers are much easier in axial direction. In this experiment, there is no need for the use of micropipette and its challenges or the use of two-edged trap. The polymer can be stuck from one end to the sample vessel and it can be pulled from the other end towards axial direction. This arrangement is much easier and more optimized, and it is the only solution in some cases.
Results of the research have been published in Optics Letters, vol. 38, issue 5, 2013. For more information about the details of the research, study the full paper on pages 685-687 on the same journal.
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