Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > JPK reports on the use of the NanoTracker optical tweezers system at the Mechanobiology Institute at the National University of Singapore

Dr Hu Chen of the National University of Singapore with his JPK NanoTracker optical tweezers system
Dr Hu Chen of the National University of Singapore with his JPK NanoTracker optical tweezers system

Abstract:
JPK Instruments, a world-leading manufacturer of nanoanalytic instrumentation for research in life sciences and soft matter, reports on the Yan Jie single molecule biophysics research group at the Mechanobiology Institute of NUS and their use of optical tweezers.

JPK reports on the use of the NanoTracker optical tweezers system at the Mechanobiology Institute at the National University of Singapore

Berlin, Germany | Posted on June 4th, 2013

The Mechanobiology Institute (MBI) of the National University of Singapore (NUS) was created through joint funding by the National Research Foundation and the Ministry of Education with the goal of creating a new research center in mechanobiology to benefit both the discipline and Singapore. Its' primary focus is to identify, measure and describe how the forces for motility and morphogenesis are expressed at the molecular, cellular and tissue level.

Dr Jie Yan is an associate professor in the Department of Physics of NUS and is a Principal Investigator of the MBI. His research is based on highly sensitive single-molecule manipulation and imaging techniques. It also requires understanding mechanics of biopolymers. One of his team, Dr Hu Chen, is a post-doctoral research fellow and he describes his topics of research. "We are doing single molecular biophysics studies. The projects cover DNA mechanics, protein-DNA interaction, chromatin dynamics, and cytoskeleton dynamics and force-sensing mechanism. We chose to use the JPK Instruments commercial NanoTracker® system to study the polymerization process of cytoskeletal fibers such as actin and microtubules by combining fluorescence and manipulation methods."

He continued: "Before purchasing the NanoTracker, our main tools were magnetic tweezers and AFM. Now with optical tweezers, we have a complimentary powerful system that combines manipulation of molecules, measurement of their force responses, as well as seeing them by fluorescence tagging. Such capability makes some difficult projects doable, and we already have some progress to see the polymerization process of actin fibers."

For single molecule manipulation, the group is using magnetic tweezers. For fluorescence imaging, they use TIRF microscope. AFM is also used to image DNA or protein/DNA complexes deposited on flat mica surfaces. As Dr Chen says, "Now with the JPK NanoTracker, we have a convenient means to combine both molecular manipulation with fluorescent imaging."

For more details about JPK's specialist products and applications for the bio and nano sciences, please contact JPK on +49 30533112070, visit the web site: www.jpk.com or see more on Facebook: www.jpk.com/facebook and on You Tube: www.youtube.com/jpkinstruments.

####

About JPK Instruments (JPK)
JPK Instruments AG is a world-leading manufacturer of nanoanalytic instruments – particularly atomic force microscope (AFM) systems and optical tweezers - for a broad range of applications reaching from soft matter physics to nano-optics, from surface chemistry to cell and molecular biology. From its earliest days applying atomic force microscope (AFM) technology, JPK has recognized the opportunities provided by nanotechnology for transforming life sciences and soft matter research. This focus has driven JPK's success in uniting the worlds of nanotechnology tools and life science applications by offering cutting-edge technology and unique applications expertise. Headquartered in Berlin and with direct operations in Dresden, Cambridge (UK), Singapore, Tokyo and Paris (France), JPK maintains a global network of distributors and support centers and provides on the spot applications and service support to an ever-growing community of researchers.

For more information, please click here

Contacts:
JPK Instruments AG
Bouchéstrasse 12
Haus 2, Aufgang C
Berlin 12435
Germany
T +49 30533112070
F +49 30 5331 22555
www.jpk.com



Bouchéstrasse 12
Haus 2, Aufgang C
Berlin 12435
Germany
T +49 30533112070
F +49 30 5331 22555
www.jpk.com
Talking Science Limited
39 de Bohun Court
Saffron Walden
Essex CB10 2BA
United Kingdom
T +44(0)1799 521881
M +44(0)7843 012997
www.talking-science.com

Copyright © JPK Instruments (JPK)

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Organometallics welcomes new editor-in-chief: Paul Chirik, Ph.D. July 22nd, 2014

The Hiden EQP Plasma Diagnostic with on-board MCA July 22nd, 2014

Iran to Hold 3rd Int'l Forum on Nanotechnology Economy July 22nd, 2014

Nanometrics Announces Upcoming Investor Events July 22nd, 2014

Nanomedicine

Researchers create vaccine for dust-mite allergies Main Page Content: Vaccine reduced lung inflammation to allergens in lab and animal tests July 22nd, 2014

NIST shows ultrasonically propelled nanorods spin dizzyingly fast July 22nd, 2014

SentiMag® Now Available in Australia and New Zealand July 21st, 2014

More than glitter: Scientists explain how gold nanoparticles easily penetrate cells, making them useful for delivering drugs July 21st, 2014

Announcements

Nanometrics Announces Upcoming Investor Events July 22nd, 2014

Bruker Awarded Fourth PeakForce Tapping Patent: AFM Mode Uniquely Combines Highest Resolution Imaging and Material Property Mapping July 22nd, 2014

NIST shows ultrasonically propelled nanorods spin dizzyingly fast July 22nd, 2014

Penn Study: Understanding Graphene’s Electrical Properties on an Atomic Level July 22nd, 2014

Tools

EPFL Research on the use of AFM based nanoscale IR spectroscopy for the study of single amyloid molecules wins poster competition at Swiss Physics Society meeting July 22nd, 2014

The Hiden EQP Plasma Diagnostic with on-board MCA July 22nd, 2014

Nanometrics Announces Upcoming Investor Events July 22nd, 2014

Bruker Awarded Fourth PeakForce Tapping Patent: AFM Mode Uniquely Combines Highest Resolution Imaging and Material Property Mapping July 22nd, 2014

Nanobiotechnology

Production of Non-Virus Nanocarriers with Highest Amount of Gene Delivery July 17th, 2014

Physicists Use Computer Models to Reveal Quantum Effects in Biological Oxygen Transport: The team solved a long-standing question by explaining why oxygen – and not deadly carbon monoxide – preferably binds to the proteins that transport it around the body. July 17th, 2014

Tiny DNA pyramids enter bacteria easily -- and deliver a deadly payload July 9th, 2014

Artificial cilia: Scientists from Kiel University develop nano-structured transportation system July 4th, 2014

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE