Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > Nanoparticle Harnesses Powerful Radiation Therapy for Cancer

Abstract:
Researchers at the University of Missouri have demonstrated the ability to create a multi-layered harness nanoparticle that can safely encapsulate powerful alpha-emitting radioisotopes and target tumors. The resulting nanoparticles not only offer the possibility of delivering tumor-killing alpha emitters to tumors, but also sparing healthy tissue from radiation damage. J. David Robinson and his colleagues published their findings in the journal PLoS One.

Nanoparticle Harnesses Powerful Radiation Therapy for Cancer

Bethesda, MD | Posted on May 20th, 2013

Typically, when radiation treatment is recommended for cancer patients, doctors are able to deliver radiation from a source outside the body or they might inject one of several radiopharmaceuticals that emit low-energy radiation known as beta particles. For years, scientists have been studying how to use "alpha emitters," which are radioactive elements that release high-energy alpha particles that would more effectively damage cancer cells and trigger cell death. The challenge to using alpha emitters is that the decay elements, the so-called daughters, are themselves highly toxic and difficult to contain in the vicinity of the tumor, thus causing significant damage to healthy tissues.

"If you think of beta particles as slingshots or arrows, alpha particles would be similar to cannon balls," said Dr. Robertson. He explains that recent work has shown that alpha particles can be effective in treating cancer in specific instances. "For example, a current study using radium-223 chloride, which emits alpha particles, has been fast-tracked by the U.S. Food and Drug Administration because it has been shown to be effective in treating bone cancer. However, it only works for bone cancer because the element, radium, is attracted to the bone and stays there. We believe we have found a solution that will allow us to target alpha particles to other cancer sites in the body in an effective manner."

In their studies, Dr. Robertson and colleagues from Oak Ridge National Laboratory and the School of Medicine at the University of Tennessee in Knoxville used the isotope actinium-225, an element that when it decays produces a high-energy alpha particle and radioactive daughter elements, which are also capable of emitting alpha particles. Efforts to contain the daughter elements using traditional molecular constraints proved fruitless because the emitted alpha particles broke the chemical bonds necessary to hold the daughter elements in place.

The Missouri team solved this problem by sequestering actinium-225 in the core of a gold-coated magnetic nanoparticle. The magnetic layer, comprised of gadolinium phosphate, serves to increase retention of the daughter elements while simplifying particle purification and the gold coating provides a surface to which tumor-targeting molecules can be attached. In the experiments described in their current publication, the researchers used an antibody that targets a receptor found on the surface of lung tumors.

"Holding these alpha emitters in place is a technical challenge that researchers have been trying to overcome for 15 years," Dr. Robertson said. "With our nanoparticle design, we are able to keep more than 80 percent of the element inside the nanoparticle 24 hours after it is created." While alpha particles are extremely powerful, they do not travel very far, so when the nanoparticles get close to the targeted cancer cells, the alpha particles are more selective at damaging cancer cells but not surrounding cells.

####

About The National Cancer Institute (NCI)
To help meet the goal of reducing the burden of cancer, the National Cancer Institute (NCI), part of the National Institutes of Health, is engaged in efforts to harness the power of nanotechnology to radically change the way we diagnose, treat and prevent cancer.

The NCI Alliance for Nanotechnology in Cancer is a comprehensive, systematized initiative encompassing the public and private sectors, designed to accelerate the application of the best capabilities of nanotechnology to cancer.

Currently, scientists are limited in their ability to turn promising molecular discoveries into benefits for cancer patients. Nanotechnology can provide the technical power and tools that will enable those developing new diagnostics, therapeutics, and preventives to keep pace with today’s explosion in knowledge.

For more information, please click here

Contacts:
National Cancer Institute
Office of Technology & Industrial Relations
ATTN: NCI Alliance for Nanotechnology in Cancer
Building 31, Room 10A49
31 Center Drive , MSC 2580
Bethesda , MD 20892-2580

Copyright © The National Cancer Institute (NCI)

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

View paper - "Gold coated lanthanide phosphate nanoparticles for targeted alpha generator radiotherapy."

Related News Press

News and information

Tough foam from tiny sheets: Rice University lab uses atom-thick materials to make ultralight foam July 29th, 2014

Zenosense, Inc. July 29th, 2014

Optimum inertial design for self-propulsion: A new study investigates the effects of small but finite inertia on the propulsion of micro and nano-scale swimming machines July 29th, 2014

A new way to make microstructured surfaces: Method can produce strong, lightweight materials with specific surface properties July 29th, 2014

Govt.-Legislation/Regulation/Funding/Policy

Tough foam from tiny sheets: Rice University lab uses atom-thick materials to make ultralight foam July 29th, 2014

A new way to make microstructured surfaces: Method can produce strong, lightweight materials with specific surface properties July 29th, 2014

Seeing is bead-lieving: Rice University scientists create model 'bead-spring' chains with tunable properties July 28th, 2014

Stanford team achieves 'holy grail' of battery design: A stable lithium anode - Engineers use carbon nanospheres to protect lithium from the reactive and expansive problems that have restricted its use as an anode July 27th, 2014

Nanomedicine

Zenosense, Inc. July 29th, 2014

Optimum inertial design for self-propulsion: A new study investigates the effects of small but finite inertia on the propulsion of micro and nano-scale swimming machines July 29th, 2014

FEI adds Phase Plate Technology and Titan Halo TEM to its Structural Biology Product Portfolio: New solutions provide the high-quality imaging and contrast necessary to analyze the 3D structure of molecules and molecular complexes July 28th, 2014

New imaging agent provides better picture of the gut July 25th, 2014

Discoveries

Tough foam from tiny sheets: Rice University lab uses atom-thick materials to make ultralight foam July 29th, 2014

Zenosense, Inc. July 29th, 2014

Optimum inertial design for self-propulsion: A new study investigates the effects of small but finite inertia on the propulsion of micro and nano-scale swimming machines July 29th, 2014

A new way to make microstructured surfaces: Method can produce strong, lightweight materials with specific surface properties July 29th, 2014

Announcements

Tough foam from tiny sheets: Rice University lab uses atom-thick materials to make ultralight foam July 29th, 2014

Zenosense, Inc. July 29th, 2014

Optimum inertial design for self-propulsion: A new study investigates the effects of small but finite inertia on the propulsion of micro and nano-scale swimming machines July 29th, 2014

A new way to make microstructured surfaces: Method can produce strong, lightweight materials with specific surface properties July 29th, 2014

Interviews/Book Reviews/Essays/Reports/Podcasts/Journals

ACS Biomaterials Science & Engineering™: Brand-new journal names editor July 29th, 2014

Tough foam from tiny sheets: Rice University lab uses atom-thick materials to make ultralight foam July 29th, 2014

Optimum inertial design for self-propulsion: A new study investigates the effects of small but finite inertia on the propulsion of micro and nano-scale swimming machines July 29th, 2014

A new way to make microstructured surfaces: Method can produce strong, lightweight materials with specific surface properties July 29th, 2014

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE