Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > Columbia Engineers Manipulate a Buckyball by Inserting a Single Water Molecule: Nanoscale Technology Used to Drive a “Big" C60 through a "Small" H2O May Help Drug Delivery

Abstract:
Columbia Engineering researchers have developed a technique to isolate a single water molecule inside a buckyball, or C60, and to drive motion of the so-called "big" nonpolar ball through the encapsulated "small" polar H2O molecule, a controlling transport mechanism in a nanochannel under an external electric field. They expect this method will lead to an array of new applications, including effective ways to control drug delivery and to assemble C60-based functional 3D structures at the nanoscale level, as well as expanding our understanding of single molecule properties. The study was published as a "Physics Focus" in the April 12 issue of Physical Review Letters.

Columbia Engineers Manipulate a Buckyball by Inserting a Single Water Molecule: Nanoscale Technology Used to Drive a “Big" C60 through a "Small" H2O May Help Drug Delivery

New York, NY | Posted on May 6th, 2013

"Buckyballs, more formally known as Buckminsterfullerenes, or fullerenes, are spherical, hollow molecular structures made of 60 carbon atoms, with the size of ~1 nm—6,000-8,000 times smaller than a regular red blood cell— and, because of their highly symmetrical structure, very hydrophobic core, covalent nonpolar bonds, and more importantly, relatively non-toxicity to the human body, they are a perfect container for drug molecules," explains Xi Chen, associate professor of earth and environmental engineering, who led the research. He and his team believe their work is the first attempt to manipulate a nonpolar molecule (C60) or structure by an inserted polar molecule (H2O).

Chen says his findings may open a new way of controlling and delivering a nonpolar "big" molecule like C60 through the encapsulated "small" polar molecule like H2O. This could lead to important applications in nanotech and biotech areas, including drug delivery where researchers can "imprison" the polar drug molecules inside a hollow structure and then guide them to their targets.

And, from a fundamental point of view, he hopes that the isolated, encapsulated single molecule, like the H2O one in his study, will provide an important platform for revealing and probing inherent characteristics of a single molecule, free from its outside environment.

"The important role of hydrogen bonds in the properties of water, like surface tension and viscosity, and the precise interactions between a single water molecule and hydrogen bonds, are still unclear," Chen notes, "so our new technique to isolate a single water molecule free from any hydrogen bonds provides an opportunity for answering these questions."

Since the discovery of C60 in the 1980s, scientists have been trying to solve the challenge of controlling a single C60. Several mechanical strategies involving AFM (atomic force microscopy) have been developed, but these are costly and time-intensive. The ability to drive a single C60 through a simple external force field, such as an electrical or magnetic field, would be a major step forward.

In the Columbia Engineering study, the researchers found that, when they encapsulated a polar molecule within a nonpolar fullerene, they could use an external electrical field to transport the structures to desired positions and adjust the transport velocity so that both delivery direction and time were controllable. Chen's team came up with the idea a year ago, and confirmed their surprising results through extensive atomistic simulations.

Chen plans to explore more properties of the molecule and other similar structures, and to continue probing the interaction and communication of the encapsulated single water molecule with its surroundings.

"Studying the communication of an imprisoned single water molecule with its outside environment such as adjacent molecules," he adds, "is like learning how a person sitting inside a room makes connections with friends outside, selectively on demand (i.e. with control) or randomly (without control) through, say, over the phone."

This research was funded by the National Science Foundation and DARPA (Defense Advanced Research Projects Agency.

####

About Columbia Engineering
Columbia University's Fu Foundation School of Engineering and Applied Science, founded in 1864, offers programs in nine departments to both undergraduate and graduate students. With facilities specifically designed and equipped to meet the laboratory and research needs of faculty and students, Columbia Engineering is home to NSF-NIH funded centers in genomic science, molecular nanostructures, materials science, and energy, as well as one of the world’s leading programs in financial engineering. These interdisciplinary centers are leading the way in their respective fields while individual groups of engineers and scientists collaborate to solve some of modern society’s more difficult challenges.

For more information, please click here

Contacts:
Holly Evarts
Director
Strategic Communications and Media Relations
212-854-3206 (o)
347-453-7408 (c)

Copyright © Columbia Engineering

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Haydale Secures Exclusive Development and Supply Agreement with Tantec A/S: New reactors to be built and commissioned by Tantec A/S represent another step forward towards the commercialisation of graphene October 24th, 2014

QuantumWise guides the semiconductor industry towards the atomic scale October 24th, 2014

MEMS & Sensors Technology Showcase: Finalists Announced for MEMS Executive Congress US 2014 October 23rd, 2014

Nanoparticle technology triples the production of biogas October 23rd, 2014

Govt.-Legislation/Regulation/Funding/Policy

Novel Rocket Design Flight Tested: New Rocket Propellant and Motor Design Offers High Performance and Safety October 23rd, 2014

Strengthening thin-film bonds with ultrafast data collection October 23rd, 2014

Brookhaven Lab Launches Computational Science Initiative:Leveraging computational science expertise and investments across the Laboratory to tackle "big data" challenges October 22nd, 2014

Bipolar Disorder Discovery at the Nano Level: Tiny structures found in brain synapses help scientists better understand disorder October 22nd, 2014

Nanotubes/Buckyballs

Materials for the next generation of electronics and photovoltaics: MacArthur Fellow develops new uses for carbon nanotubes October 21st, 2014

Special UO microscope captures defects in nanotubes: University of Oregon chemists provide a detailed view of traps that disrupt energy flow, possibly pointing toward improved charge-carrying devices October 21st, 2014

Imaging electric charge propagating along microbial nanowires October 20th, 2014

Beyond LEDs: Brighter, new energy-saving flat panel lights based on carbon nanotubes - Planar light source using a phosphor screen with highly crystalline single-walled carbon nanotubes (SWCNTs) as field emitters demonstrates its potential for energy-efficient lighting device October 14th, 2014

Nanomedicine

NYU Researchers Break Nano Barrier to Engineer the First Protein Microfiber October 23rd, 2014

Iranian Scientists Apply Nanotechnology to Produce Surgery Suture October 23rd, 2014

RF Heating of Magnetic Nanoparticles Improves the Thawing of Cryopreserved Biomaterials October 23rd, 2014

Sopping up proteins with thermosponges: Researchers develop novel nanoparticle platform that proves effective in delivering protein-based drugs October 22nd, 2014

Discoveries

QuantumWise guides the semiconductor industry towards the atomic scale October 24th, 2014

Iranian, Malaysian Scientists Study Nanophotocatalysts for Water Purification October 23rd, 2014

Nanoparticle technology triples the production of biogas October 23rd, 2014

Strengthening thin-film bonds with ultrafast data collection October 23rd, 2014

Announcements

Haydale Secures Exclusive Development and Supply Agreement with Tantec A/S: New reactors to be built and commissioned by Tantec A/S represent another step forward towards the commercialisation of graphene October 24th, 2014

QuantumWise guides the semiconductor industry towards the atomic scale October 24th, 2014

Advancing thin film research with nanostructured AZO: Innovnano’s unique and cost-effective AZO sputtering targets for the production of transparent conducting oxides October 23rd, 2014

Strengthening thin-film bonds with ultrafast data collection October 23rd, 2014

Military

NanoTechnology for Defense (NT4D) October 22nd, 2014

Crystallizing the DNA nanotechnology dream: Scientists have designed the first large DNA crystals with precisely prescribed depths and complex 3D features, which could create revolutionary nanodevices October 20th, 2014

Imaging electric charge propagating along microbial nanowires October 20th, 2014

1980s aircraft helps quantum technology take flight October 20th, 2014

Water

Iranian, Malaysian Scientists Study Nanophotocatalysts for Water Purification October 23rd, 2014

New Nanocomposites Help Elimination of Toxic Dyes October 15th, 2014

Fast, cheap nanomanufacturing: Arrays of tiny conical tips that eject ionized materials could fabricate nanoscale devices cheaply October 4th, 2014

Production of Filters for Separation of Water from Petroleum Products in Iran October 1st, 2014

NanoNews-Digest
The latest news from around the world, FREE





  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE