Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Iranian Researchers Use Modified Nanogels for Drug Delivery to Brain

Abstract:
Pharmaceutical researchers from Tehran and Zanjan Universities of Medical Sciences optimized the drug therapy of brain tumors by improving the process of diffusion and penetration of methotrexate into the central neural system by using nanogel carriers.

Iranian Researchers Use Modified Nanogels for Drug Delivery to Brain

Tehran, Iran | Posted on March 26th, 2013

By using these nanogels, they delivered drugs into the brain in low doze with more effectiveness and less side effects.

According to the researchers of the plan, the outside-body evaluation tests, including particle size, particle size distribution, surface charges, morphology, chemical assessment, and studying drug release on the produced nanogels have already been carried out. The tests generally confirmed that the nanogels were desirable to carry medicine into the central nerves. Moreover, the nanogels showed an appropriate behavior in outside-body drug release.

Hydrogel nanoparticles possess a specific position among other drug delivery systems due to their ability to show the properties of both hydrogels and nanoparticles at the same time. Although the mechanism of the transportation of nanoparticles loaded with medicine through blood-brain block is not discovered yet, it seems that nanogels are bind with brain capillary endothelial cells after being injected into the blood stream and sticking to apolipoproteins. Then, they enter endothelial cells through endocytosis (with the help of the receivers). This is the most probable mechanism.

The present research focuses on outside-body and laboratorial studies, being carried out in Biopharmacy and Pharmacokinetics Laboratories of Pharmaceutics Faculty of Tehran University of Medical Sciences. The inside-body studies (animal studies) are currently being carried out too.

Results of the research have been published on 1 September 2012 in Carbohydrate Polymers, vol. 90, issue 1. Visit the full paper on pages 462-471 of the same journals.

####

For more information, please click here

Copyright © Fars News Agency

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Particles from outer space are wreaking low-grade havoc on personal electronics February 19th, 2017

Liquid metal nano printing set to revolutionize electronics: Creating integrated circuits just atoms thick February 18th, 2017

Engineers shrink microscope to dime-sized device February 17th, 2017

Francis Alexander Named Deputy Director of Brookhaven Lab's Computational Science Initiative February 16th, 2017

Nanomedicine

Good vibrations help reveal molecular details: Rice University scientists combine disciplines to pinpoint small structures in unlabeled molecules February 15th, 2017

In-cell molecular sieve from protein crystal February 14th, 2017

Cedars-Sinai, UCLA Scientists Use New ‘Blood Biopsies’ With Experimental Device to Speed Cancer Diagnosis and Predict Disease Spread: Leading-Edge Research Is Part of National Cancer Moonshot Initiative February 13th, 2017

Meta-lenses bring benchtop performance to small, hand-held spectrometer: Game-changing nanostructure-based lenses allow smaller devices, increased functionality February 9th, 2017

Discoveries

Particles from outer space are wreaking low-grade havoc on personal electronics February 19th, 2017

Liquid metal nano printing set to revolutionize electronics: Creating integrated circuits just atoms thick February 18th, 2017

Engineers shrink microscope to dime-sized device February 17th, 2017

Research opens door to smaller, cheaper, more agile communications tech February 16th, 2017

Announcements

Particles from outer space are wreaking low-grade havoc on personal electronics February 19th, 2017

Liquid metal nano printing set to revolutionize electronics: Creating integrated circuits just atoms thick February 18th, 2017

Engineers shrink microscope to dime-sized device February 17th, 2017

Francis Alexander Named Deputy Director of Brookhaven Lab's Computational Science Initiative February 16th, 2017

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project