Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > Iranian Researchers Use Modified Nanogels for Drug Delivery to Brain

Abstract:
Pharmaceutical researchers from Tehran and Zanjan Universities of Medical Sciences optimized the drug therapy of brain tumors by improving the process of diffusion and penetration of methotrexate into the central neural system by using nanogel carriers.

Iranian Researchers Use Modified Nanogels for Drug Delivery to Brain

Tehran, Iran | Posted on March 26th, 2013

By using these nanogels, they delivered drugs into the brain in low doze with more effectiveness and less side effects.

According to the researchers of the plan, the outside-body evaluation tests, including particle size, particle size distribution, surface charges, morphology, chemical assessment, and studying drug release on the produced nanogels have already been carried out. The tests generally confirmed that the nanogels were desirable to carry medicine into the central nerves. Moreover, the nanogels showed an appropriate behavior in outside-body drug release.

Hydrogel nanoparticles possess a specific position among other drug delivery systems due to their ability to show the properties of both hydrogels and nanoparticles at the same time. Although the mechanism of the transportation of nanoparticles loaded with medicine through blood-brain block is not discovered yet, it seems that nanogels are bind with brain capillary endothelial cells after being injected into the blood stream and sticking to apolipoproteins. Then, they enter endothelial cells through endocytosis (with the help of the receivers). This is the most probable mechanism.

The present research focuses on outside-body and laboratorial studies, being carried out in Biopharmacy and Pharmacokinetics Laboratories of Pharmaceutics Faculty of Tehran University of Medical Sciences. The inside-body studies (animal studies) are currently being carried out too.

Results of the research have been published on 1 September 2012 in Carbohydrate Polymers, vol. 90, issue 1. Visit the full paper on pages 462-471 of the same journals.

####

For more information, please click here

Copyright © Fars News Agency

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Iran to Hold 3rd Int'l Engineering Materials, Metallurgy Conference October 25th, 2014

Haydale Secures Exclusive Development and Supply Agreement with Tantec A/S: New reactors to be built and commissioned by Tantec A/S represent another step forward towards the commercialisation of graphene October 24th, 2014

QuantumWise guides the semiconductor industry towards the atomic scale October 24th, 2014

SUNY Polytechnic Institute Invites the Public to Attend its Popular Statewide 'NANOvember' Series of Outreach and Educational Events October 23rd, 2014

Nanomedicine

NYU Researchers Break Nano Barrier to Engineer the First Protein Microfiber October 23rd, 2014

Iranian Scientists Apply Nanotechnology to Produce Surgery Suture October 23rd, 2014

RF Heating of Magnetic Nanoparticles Improves the Thawing of Cryopreserved Biomaterials October 23rd, 2014

Sopping up proteins with thermosponges: Researchers develop novel nanoparticle platform that proves effective in delivering protein-based drugs October 22nd, 2014

Discoveries

QuantumWise guides the semiconductor industry towards the atomic scale October 24th, 2014

Iranian, Malaysian Scientists Study Nanophotocatalysts for Water Purification October 23rd, 2014

Nanoparticle technology triples the production of biogas October 23rd, 2014

Strengthening thin-film bonds with ultrafast data collection October 23rd, 2014

Announcements

Iran to Hold 3rd Int'l Engineering Materials, Metallurgy Conference October 25th, 2014

Haydale Secures Exclusive Development and Supply Agreement with Tantec A/S: New reactors to be built and commissioned by Tantec A/S represent another step forward towards the commercialisation of graphene October 24th, 2014

QuantumWise guides the semiconductor industry towards the atomic scale October 24th, 2014

Strengthening thin-film bonds with ultrafast data collection October 23rd, 2014

NanoNews-Digest
The latest news from around the world, FREE





  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE