Nanotechnology Now

Our NanoNews Digest Sponsors



Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > Iranian Researchers Use Modified Nanogels for Drug Delivery to Brain

Abstract:
Pharmaceutical researchers from Tehran and Zanjan Universities of Medical Sciences optimized the drug therapy of brain tumors by improving the process of diffusion and penetration of methotrexate into the central neural system by using nanogel carriers.

Iranian Researchers Use Modified Nanogels for Drug Delivery to Brain

Tehran, Iran | Posted on March 26th, 2013

By using these nanogels, they delivered drugs into the brain in low doze with more effectiveness and less side effects.

According to the researchers of the plan, the outside-body evaluation tests, including particle size, particle size distribution, surface charges, morphology, chemical assessment, and studying drug release on the produced nanogels have already been carried out. The tests generally confirmed that the nanogels were desirable to carry medicine into the central nerves. Moreover, the nanogels showed an appropriate behavior in outside-body drug release.

Hydrogel nanoparticles possess a specific position among other drug delivery systems due to their ability to show the properties of both hydrogels and nanoparticles at the same time. Although the mechanism of the transportation of nanoparticles loaded with medicine through blood-brain block is not discovered yet, it seems that nanogels are bind with brain capillary endothelial cells after being injected into the blood stream and sticking to apolipoproteins. Then, they enter endothelial cells through endocytosis (with the help of the receivers). This is the most probable mechanism.

The present research focuses on outside-body and laboratorial studies, being carried out in Biopharmacy and Pharmacokinetics Laboratories of Pharmaceutics Faculty of Tehran University of Medical Sciences. The inside-body studies (animal studies) are currently being carried out too.

Results of the research have been published on 1 September 2012 in Carbohydrate Polymers, vol. 90, issue 1. Visit the full paper on pages 462-471 of the same journals.

####

For more information, please click here

Copyright © Fars News Agency

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

NMTI announces breakthrough solutions for HAMR nanoantenna for next-generation ultra-high density magnetic storage November 21st, 2014

Leica Microsystems Presents Universal Hybrid Detector for Single Molecule Detection and Imaging at SfN and ASCB: Leica HyD SMD - the Optimal Detector for Precise and Reliable SMD data November 20th, 2014

Silver Nanoparticles Produced in Iran from Forest Plants Extract November 20th, 2014

Nano Sorbents Able to Remove Pollutions Caused by Oil Derivatives November 20th, 2014

Nanomedicine

Quantum mechanical calculations reveal the hidden states of enzyme active sites November 20th, 2014

Silver Nanoparticles Produced in Iran from Forest Plants Extract November 20th, 2014

Tokyo Institute of Technology research: Protein-engineered cages aid studies of cell functions November 19th, 2014

A novel method for identifying the body’s ‘noisiest’ networks November 19th, 2014

Discoveries

NMTI announces breakthrough solutions for HAMR nanoantenna for next-generation ultra-high density magnetic storage November 21st, 2014

UO-industry collaboration points to improved nanomaterials: University of Oregon microscope puts spotlight on the surface structure of quantum dots for designing new solar devices November 20th, 2014

Silver Nanoparticles Produced in Iran from Forest Plants Extract November 20th, 2014

Nano Sorbents Able to Remove Pollutions Caused by Oil Derivatives November 20th, 2014

Announcements

NMTI announces breakthrough solutions for HAMR nanoantenna for next-generation ultra-high density magnetic storage November 21st, 2014

Leica Microsystems Presents Universal Hybrid Detector for Single Molecule Detection and Imaging at SfN and ASCB: Leica HyD SMD - the Optimal Detector for Precise and Reliable SMD data November 20th, 2014

Silver Nanoparticles Produced in Iran from Forest Plants Extract November 20th, 2014

Nano Sorbents Able to Remove Pollutions Caused by Oil Derivatives November 20th, 2014

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More












ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE