Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Reversible assembly leads to tiny encrypted messages

Photo by
L. Brian Stauffer

U. of I. chemistry professor Yi Lu and his research group developed a method for reversible and dymanic nano-assembly and used it to encrypt Morse code messages on a DNA origami tile.
Photo by L. Brian Stauffer

U. of I. chemistry professor Yi Lu and his research group developed a method for reversible and dymanic nano-assembly and used it to encrypt Morse code messages on a DNA origami tile.

Abstract:
Hidden in a tiny tile of interwoven DNA is a message. The message is simple, but decoding it unlocks the secret of dynamic nanoscale assembly.

Researchers at the University of Illinois at Urbana-Champaign have devised a dynamic and reversible way to assemble nanoscale structures and used it to encrypt a Morse code message. Led by Yi Lu, the Schenck Professor of Chemistry, the team published its development in the Journal of the American Chemical Society.

Reversible assembly leads to tiny encrypted messages

Champaign, IL | Posted on March 11th, 2013

Scientists and engineers who work with nanoscale materials use an important technique called programmable assembly to strategically combine simple building blocks into larger functional components or structures. Such assembly is important for applications in electronics, photonics, medicine and much more.

Most standard nano-assembly techniques yield a particular, static product. But looking at biology, Lu saw a lot of dynamic assemblies: reversible building processes, or substitutions that could be made after assembly to add or change function. Such versatility could enable many more applications for nanoscale materials, so Lu's group set out to explore nanoscale systems that could reliably and reversibly assemble.

"I think a critical challenge facing nanoscale science and engineering is reversible assembly," Lu said. "Researchers are now pretty good at putting components in places they desire, but not very good at putting something on and taking it off again. Many applications need dynamic assembly. You don't just want to assemble it once, you want to do it repeatedly, and not only using the same component, but also new components."

The group took advantage of a chemical system common in biology. The protein streptavidin binds very strongly to the small organic molecule biotin - it grabs on and doesn't let go. A small chemical tweak to biotin yields a molecule that also binds to streptavidin, but holds it loosely.

The researchers started with a template of DNA origami - multiple strands of DNA woven into a tile. They "wrote" their message in the DNA template by attaching biotin-bound DNA strands to specific locations on the tiles that would light up as dots or dashes. Meanwhile, DNA bound to the biotin derivative filled the other positions on the DNA template.

Then they bathed the tiles in a streptavidin solution. The streptavidin bonded to both the biotin and its derivative, making all the spots "light up" under an atomic force microscope and camouflaging the message. To reveal the hidden message, the researchers then put the tiles in a solution of free biotin. Since it binds to streptavidin so much more strongly, the biotin effectively removed the protein from the biotin derivative, so that only the DNA strands attached to the unaltered biotin kept hold of their streptavidin. The Morse code message, "NANO," was clearly readable under the microscope.

The researchers also demonstrated non-Morse characters, creating tiles that could switch back and forth between a capital "I" and a lowercase "i" as streptavidin and biotin were alternately added. (See an animation of the process.)

"This is an important step forward for nanoscale assembly," Lu said. "Now we can encode messages in much smaller scale, which is interesting. There's more information per square inch. But the more important advance is that now that we can carry out reversible assembly, we can explore much more versatile, much more dynamic applications."

Next, the researchers plan to use their technique to create other functional systems. Lu envisions assembling systems to perform a task in chemistry, biology, sensing, photonics or other area, then replacing a component to give the system an additional function. Since the key to reversibility is in the different binding strengths, the technique is not limited to the biotin-streptavidin system and could work for a variety of molecules and materials.

"As long as the molecules used in the assembly have two different affinities, we can apply this particular concept into other templates or processes," Lu said.

The National Science Foundation supported this work. Graduate students Ngo Yin Wong, Hang Xing and Li Huey Tan were co-authors of the paper. Lu also is affiliated with the department of bioengineering, the Beckman Institute for Advanced Science and Technology, and the Frederick Seitz Materials Research Laboratory at the U. of I.

####

For more information, please click here

Contacts:
Liz Ahlberg
Physical Sciences Editor
217-244-1079


Yi Lu
217-333-2619

Copyright © University of Illinois at Urbana-Champaign

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

The paper, “Nano-Encrypted Morse Code: A Versatile Approach to Programmable and Reversible Nanoscale Assembly and Disassembly,” is available online:

VIDEO: A DNA origami template seeded with biotin (blue) and a biotin derivative (green) to make a capital “I.” The protein streptavidin (red) binds to both molecules. When additional biotin is added, it removes the protein from the biotin derivative, revealing a lower case “i". Later, when more protein is added, the capital “I” is re-assembled.

Related News Press

News and information

A new product to help combat mouldy walls, thanks to technology developed at the ICN2 December 14th, 2017

Sandia researchers make solid ground toward better lithium-ion battery interfaces: Reducing the traffic jam in batteries December 13th, 2017

Perking up and crimping the 'bristles' of polyelectrolyte brushes December 13th, 2017

Columbia engineers create artificial graphene in a nanofabricated semiconductor structure: Researchers are the first to observe the electronic structure of graphene in an engineered semiconductor; finding could lead to progress in advanced optoelectronics and data processing December 13th, 2017

Leti to Demo Wristband with Embedded Sensors to Diagnose Sleep Apnea: APNEAband, Which Will Be Demonstrated at CES 2018, Also Monitors Mountain Sickness, Dehydration, Dialysis Treatment Response and Epileptic Seizures December 12th, 2017

Imaging

Perking up and crimping the 'bristles' of polyelectrolyte brushes December 13th, 2017

Videos/Movies

Math gets real in strong, lightweight structures: Rice University researchers use 3-D printers to turn century-old theory into complex schwarzites November 16th, 2017

A new way to mix oil and water: Condensation-based method developed at MIT could create stable nanoscale emulsions November 8th, 2017

Luleå University of Technology is using the Deben CT5000TEC stage to perform x-ray microtomography experiments with the ZEISS Xradia 510 Versa to understand deformation and strain inside inhomogeneous materials November 7th, 2017

Graphene enables high-speed electronics on flexible materials: A flexible terahertz detector has been developed by Chalmers using graphene transistors on plastic substrates. It is the first of its kind, and may open for applications requiring flexible electronics such as wireless October 31st, 2017

Govt.-Legislation/Regulation/Funding/Policy

Sandia researchers make solid ground toward better lithium-ion battery interfaces: Reducing the traffic jam in batteries December 13th, 2017

Perking up and crimping the 'bristles' of polyelectrolyte brushes December 13th, 2017

Columbia engineers create artificial graphene in a nanofabricated semiconductor structure: Researchers are the first to observe the electronic structure of graphene in an engineered semiconductor; finding could lead to progress in advanced optoelectronics and data processing December 13th, 2017

Wheat gets boost from purified nanotubes: Rice University toxicity study shows plant growth enhanced by -- but only by -- purified nanotubes December 6th, 2017

Molecular Machines

Going swimmingly: Biotemplates breakthrough paves way for cheaper nanobots: By using bacterial flagella as a template for silica, researchers have demonstrated an easier way to make propulsion systems for nanoscale swimming robots November 30th, 2017

How to draw electricity from the bloodstream: A one-dimensional fluidic nanogenerator with a high power-conversion efficiency September 11th, 2017

First 3-D observation of nanomachines working inside cells: Researchers headed by IRB Barcelona combine genetic engineering, super-resolution microscopy and biocomputation to allow them to see in 3-D the protein machinery inside living cells January 27th, 2017

Micro-bubbles make big impact: Research team develops new ultrasound-powered actuator to develop micro robot November 25th, 2016

Molecular Nanotechnology

Going swimmingly: Biotemplates breakthrough paves way for cheaper nanobots: By using bacterial flagella as a template for silica, researchers have demonstrated an easier way to make propulsion systems for nanoscale swimming robots November 30th, 2017

Spinning strands hint at folding dynamics: Rice University lab uses magnetic beads to model microscopic proteins, polymers October 17th, 2017

Assembly of nanoparticles proceeds like a zipper: Viruses and nanoparticles can be assembled into processable superlattice wires according to scientists from Aalto University Finland September 25th, 2017

First 3-D observation of nanomachines working inside cells: Researchers headed by IRB Barcelona combine genetic engineering, super-resolution microscopy and biocomputation to allow them to see in 3-D the protein machinery inside living cells January 27th, 2017

Discoveries

Sandia researchers make solid ground toward better lithium-ion battery interfaces: Reducing the traffic jam in batteries December 13th, 2017

Perking up and crimping the 'bristles' of polyelectrolyte brushes December 13th, 2017

Columbia engineers create artificial graphene in a nanofabricated semiconductor structure: Researchers are the first to observe the electronic structure of graphene in an engineered semiconductor; finding could lead to progress in advanced optoelectronics and data processing December 13th, 2017

Untangling DNA: Researchers filter the entropy out of nanopore measurements December 8th, 2017

Announcements

A new product to help combat mouldy walls, thanks to technology developed at the ICN2 December 14th, 2017

Sandia researchers make solid ground toward better lithium-ion battery interfaces: Reducing the traffic jam in batteries December 13th, 2017

Perking up and crimping the 'bristles' of polyelectrolyte brushes December 13th, 2017

Columbia engineers create artificial graphene in a nanofabricated semiconductor structure: Researchers are the first to observe the electronic structure of graphene in an engineered semiconductor; finding could lead to progress in advanced optoelectronics and data processing December 13th, 2017

Interviews/Book Reviews/Essays/Reports/Podcasts/Journals/White papers

UCLA chemists synthesize narrow ribbons of graphene using only light and heat: Tiny structures could be next-generation solution for smaller electronic devices December 8th, 2017

Device makes power conversion more efficient: New design could dramatically cut energy waste in electric vehicles, data centers, and the power grid December 8th, 2017

Creating a new kind of metallic glass December 7th, 2017

Copper will replace toxic palladium and expensive platinum in the synthesis of medications: The effectiveness of copper nanoparticles as a catalyst has been proven December 5th, 2017

Tools

Perking up and crimping the 'bristles' of polyelectrolyte brushes December 13th, 2017

Untangling DNA: Researchers filter the entropy out of nanopore measurements December 8th, 2017

JPK Instruments announce partnership with Swiss company, Cytosurge AG. The partnership makes Cytosurge’s FluidFM® technology available on the JPK NanoWizard® AFM platform December 8th, 2017

Researchers advance technique to detect ovarian cancer: Rice, MD Anderson use fluorescent carbon nanotube probes to achieve first in vivo success November 30th, 2017

Nanobiotechnology

Perking up and crimping the 'bristles' of polyelectrolyte brushes December 13th, 2017

Arrowhead Presents New Clinical Data Demonstrating a Sustained Host Response in Hepatitis B Patients Following RNAi Therapy — Up to 5.0 log10 reduction in HBsAg observed; data presented at HEP DART 2017 — December 6th, 2017

Going swimmingly: Biotemplates breakthrough paves way for cheaper nanobots: By using bacterial flagella as a template for silica, researchers have demonstrated an easier way to make propulsion systems for nanoscale swimming robots November 30th, 2017

Drug-delivering nanoparticles seek and destroy elusive cancer stem cells November 28th, 2017

Photonics/Optics/Lasers

Leti Integrates Hybrid III-V Silicon Lasers on 200mm Wafers with Standard CMOS Process December 6th, 2017

Scientists make transparent materials absorb light December 1st, 2017

Going swimmingly: Biotemplates breakthrough paves way for cheaper nanobots: By using bacterial flagella as a template for silica, researchers have demonstrated an easier way to make propulsion systems for nanoscale swimming robots November 30th, 2017

Fast flowing heat in graphene heterostructures: Surprisingly fast heat flow from graphene to its surrounding November 29th, 2017

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project