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Home > Press > Determination of N-Acetylcysteine by Carbon Paste Electrode Modified with Carbon Nanotubes

Abstract:
Iranian researchers announced that they have acquired the technology to produce carbon paste electrode modified with carbon nanotubes and manganese (III) salen which can be easily produced, recovered and used in the analysis of various samples.

Determination of N-Acetylcysteine by Carbon Paste Electrode Modified with Carbon Nanotubes

Tehran, Iran | Posted on March 5th, 2013

The carbon paste electrode also has a stable electrochemical activity in comparison to other normal electrodes, and can be used in electrochemical reactions of some of organic materials and biomolecules as a catalyst.

N-acetylcysteine (NAC) is a medicine that is used as a mucolytic agent due to its ability in breaking sulfide bonds and converting them into the two groups of sulfhydryl. When the sulfide bonds are broken, the length of their chains is decreased. Therefore, the mucous membrane can be eliminated more easily. N-acetylcysteine is a very effective antidote in case of being poisoned by acetaminophen. In addition, it has antioxidant activity and can be used in the prevention of some types of cancer.

The use of this complex with manganese as the modifier has another advantage too. It is insoluble in aqueous solutions. In the other hand, the simultaneous use of manganese complex and carbon nanotubes significantly improves the oxidation reaction of N-acetylcysteine on the electrode surface.

Results showed that the modified electrode had a very good electrocatalytic activity in the oxidation of N-acetylcysteine and folic acid. Moreover, by presenting a linear wide range, low detection level, and high stability, the modified electrode can be introduced as a very appropriate option in simultaneous determination of N-acetylcysteine and folic acid.

Results of the research have been published in August 2012 in International Journal of Electrochemical Science, vol. 7, pp. 7684-7698.

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