Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Trackable drug-filled nanoparticles -- a potential weapon against cancer

Abstract:
Tiny particles filled with a drug could be a new tool for treating cancer in the future. A new study published by Swedish scientists in Particle & Particle Systems Characterization shows how such nanoparticles can be combined to secure the effective delivery of cancer drugs to tumour cells - and how they can be given properties to make them visible in MR scanners and thus rendered trackable.

Trackable drug-filled nanoparticles -- a potential weapon against cancer

Stockholm, Sweden | Posted on February 28th, 2013

The team, which consisted of scientists from Karolinska Institutet (KI) and the Royal Institute of Technology (KTH) in Stockholm, and from Chalmers University of Technology in Gothenburg, developed so-called 'theranostic nanoparticles' by combining therapy and diagnostics in one and the same nano material.

"For this study, we produced theranostic nanoparticles able to make pinpoint deliveries of drug payloads to breast cancer cells," says Professor Eva Malmström of the School of Chemical Science and Engineering at KTH. "They are also detectable in an MR scanner and can therefore be used diagnostically. The building blocks that we use are biodegradable and show no signs of toxicity."

The new study has resulted in a method of making such theranostic nanoparticles that spontaneously form themselves out of tailored macromolecules (polymers). The balance between hydrophilic (water attracting) and hydrophobic (water repelling) components are important to the successful outcome of this process, the latter being what makes it possible for the particles to be filled with the drug. A relatively high concentration of the naturally occurring isotope 19F (fluorine) makes the particles show up clearly in high-resolution MR tomograms, and by tracking the theranostic nanoparticles through the body, researchers can learn about how the drug is taken up by the tumour and how efficacious the treatment is.

The researchers filled the nanoparticles with the chemotherapeutic doxorubicin, which is used to treat cancer of the bladder, lungs, ovaries, and breast. They showed through experiments on cultivated cells that the particles, while harmless in themselves, are effective at killing cancer cells when loaded with the drug.

The next step is to develop the system to target brain tumours, pancreatic cancer and drug-resistant breast cancer tumours, which are currently difficult to treat effectively with chemotherapy.

"Adding targeting groups to the surface or by changing the size of or adding ionic groups to our nanoparticles will make it possible to increase the selective uptake of these particles in tumours," says Dr Andreas Nyström, Associate Professor in nanomedicine at the Swedish Medical Nanoscience Center, part of Karolinska Institutet's Department of Neuroscience.

It is hoped that one day this research will lead to tailored chemotherapy treatments that specifically seek out tumour cells. In that the drug, which is toxic to the body, can be delivered more precisely to the tumour, the treatment can be made much more effective with greatly reduced side-effects.

The study was financed through a variety of sources, including a grant each from the Swedish Research Council to Dr Nyström and Professor Malmström, who also are affiliated to Polymer Factory Sweden AB.

####

For more information, please click here

Contacts:
Press Office

46-852-486-077

Andreas Nyström
Associate Professor
Swedish Medical Nanoscience Center
Department of Neuroscience
Karolinska Institutet
Tel: 46-08-524-869-42
or 46-073-596-12-91


Eva Malmström
Professor
Department of Fibre and Polymer Technology
School of Chemical Science and Engineering, KTH
Tel: 46-08-790-72-25
or 46-070-428-72-25

Copyright © Karolinska Institutet

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

Publication:'19F-based Polymer Nanoparticles as Breast Cancer Theranostics', Christian Porsch, Yuning Zhang, Åsa Östlund, Peter Damberg, Cosimo Ducani, Eva Malmström, and Andreas M. Nyström, Particle & Particle Systems Characterization, online first 28 February 2013, DOI: 10.1002/ppsc.201300018. Read the abstract:

Related News Press

News and information

Atomic force imaging used to study nematodes: KFU bionanotechnology lab (head - Dr. Rawil Fakhrullin) has obtained 3-D images of nematodes' cuticles February 23rd, 2017

Particle Works creates range of high performance quantum dots February 23rd, 2017

EmTech Asia breaks new barriers with potential applications of space exploration with NASA and MIT February 22nd, 2017

JPK selects compact tensile stage from Deben for their NanoWizard® AFM platform to broaden capabilities for materials characterisation February 22nd, 2017

Govt.-Legislation/Regulation/Funding/Policy

Atomic force imaging used to study nematodes: KFU bionanotechnology lab (head - Dr. Rawil Fakhrullin) has obtained 3-D images of nematodes' cuticles February 23rd, 2017

Molecular phenomenon discovered by advanced NMR facility: Cutting edge technology has shown a molecule self-assembling into different forms when passing between solution state to solid state, and back again - a curious phenomenon in science - says research by the University of Wa February 22nd, 2017

'Lossless' metamaterial could boost efficiency of lasers and other light-based devices February 20th, 2017

Engineers shrink microscope to dime-sized device February 17th, 2017

Nanomedicine

Atomic force imaging used to study nematodes: KFU bionanotechnology lab (head - Dr. Rawil Fakhrullin) has obtained 3-D images of nematodes' cuticles February 23rd, 2017

Nominations Invited for $250,000 Kabiller Prize in Nanoscience: Major international prize recognizes a visionary nanotechnology researcher February 20th, 2017

Good vibrations help reveal molecular details: Rice University scientists combine disciplines to pinpoint small structures in unlabeled molecules February 15th, 2017

In-cell molecular sieve from protein crystal February 14th, 2017

Discoveries

Atomic force imaging used to study nematodes: KFU bionanotechnology lab (head - Dr. Rawil Fakhrullin) has obtained 3-D images of nematodes' cuticles February 23rd, 2017

Molecular phenomenon discovered by advanced NMR facility: Cutting edge technology has shown a molecule self-assembling into different forms when passing between solution state to solid state, and back again - a curious phenomenon in science - says research by the University of Wa February 22nd, 2017

Tiny nanoclusters could solve big problems for lithium-ion batteries February 21st, 2017

Breakthrough with a chain of gold atoms: In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport February 20th, 2017

Announcements

Atomic force imaging used to study nematodes: KFU bionanotechnology lab (head - Dr. Rawil Fakhrullin) has obtained 3-D images of nematodes' cuticles February 23rd, 2017

Particle Works creates range of high performance quantum dots February 23rd, 2017

GLOBALFOUNDRIES Announces Availability of 45nm RF SOI to Advance 5G Mobile Communications: Optimized RF features deliver high-performance solutions for mmWave beam forming applications in 5G smartphones and base stations February 22nd, 2017

EmTech Asia breaks new barriers with potential applications of space exploration with NASA and MIT February 22nd, 2017

Grants/Sponsored Research/Awards/Scholarships/Gifts/Contests/Honors/Records

Oxford Instruments announces Dr Brad Ramshaw of Cornell University, as winner of the 2017 Lee Osheroff Richardson Science Prize February 20th, 2017

Nominations Invited for $250,000 Kabiller Prize in Nanoscience: Major international prize recognizes a visionary nanotechnology researcher February 20th, 2017

'Lossless' metamaterial could boost efficiency of lasers and other light-based devices February 20th, 2017

Good vibrations help reveal molecular details: Rice University scientists combine disciplines to pinpoint small structures in unlabeled molecules February 15th, 2017

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project