Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Balsam for the Bones - Chemists at the UDE develop a nanopaste for the repair of bone defects

The mode of action of the paste (photo © UDE)
The mode of action of the paste

(photo © UDE)

Abstract:
Following accidents or cancer surgery surgeons often have to transplant healthy bone tissue or synthetic material to repair the resulting bone defects. Unfortunately, these procedures do not always have the desired effect.

Balsam for the Bones - Chemists at the UDE develop a nanopaste for the repair of bone defects

Duisburg, Germany | Posted on February 20th, 2013

Now a professor for inorganic chemistry, Matthias Epple was attracted to the interface between biology and medical science. "We have been investigating the impact of mineral tissue such as teeth, bone and sea shells for many years and are now using the knowledge we have gained to produce new biomaterials." To achieve this he has collaborated closely with medical scientists and his current project - carried out with three of his doctoral students - was no exception.

"The repair of bone defects presents a real challenge for surgeons," he relates. "When possible they collect the patient's own bone from various locations, such as the iliac crest, and implant it where needed to fill defects." The researcher explained that since there is only a limited amount of surplus bone material in the body, synthetic materials are now being used. "Calcium phosphate is a natural choice here since it is an inorganic mineral found in bones in the form of nanocrystals. It is a material familiar to the body, which makes it a suitable carrier." He added that the calcium and phosphate ions lead to improved new bone formation.

However, the use of synthetic materials creates a host of new problems: the bones heal more slowly, the risk of infection is greater and the mechanical stability is not ideal. Epple's team has now created a bone repair paste by coating synthetic nanocrystals of calcium phosphate with nucleic acids - in other words, with DNA. The professor explains what happens when this paste is injected into a bone defect: "The nanoparticles are taken up by cells. The calcium phosphate dissolves and the DNA that is released stimulates the formation of two proteins important for healing: BMP-7, which stimulates bone formation, and VEGF-A, which is responsible for the creation of new blood vessels. As a result, the new bone is supplied with valuable nutrients."

The UDE researchers expect that the paste will have a long-lasting effect since the nanoparticles are released successively and thus continuously stimulate the surrounding cells. They have demonstrated that the paste works in three different cell types. Further tests now have to be conducted. Epple and his co-researchers hope that "our development will be used several years from now in the field of traumatology and in the treatment of osteoporosis."

####

For more information, please click here

Contacts:
Ulrike Bohnsack
Tel. +49 (0) 203 379 2429

Prof. Dr. Matthias Epple
University of Duisburg-Essen
Tel. +49 (0) 201 183 2413

Copyright © AlphaGalileo

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

The results of this research were recently published in the international journal RSC Advances:

Related News Press

News and information

GLOBALFOUNDRIES and Soitec Enter Into Long-term Supply Agreement on FD-SOI Wafers: Strategic milestone to help guarantee a secure, high-volume supply of FD-SOI technology September 20th, 2017

GLOBALFOUNDRIES Announces Availability of mmWave and RF/Analog on Leading FDX™ FD-SOI Technology Platform: Technology solution delivers ‘connected intelligence’ to next generation high-volume wireless and IoT applications with lower power and significantly reduced cost September 20th, 2017

GLOBALFOUNDRIES Announces Availability of Embedded MRAM on Leading 22FDX® FD-SOI Platform: Advanced embedded non-volatile memory solution delivers ‘connected intelligence’ by expanding SoC capabilities on the 22nm process node September 20th, 2017

Copper catalyst yields high efficiency CO2-to-fuels conversion: Berkeley Lab scientists discover critical role of nanoparticle transformation September 20th, 2017

Nanomedicine

Do titanium dioxide particles from orthopedic implants disrupt bone repair? September 16th, 2017

Arrowhead Hosts Investor & Analyst R&D Day to Introduce TRiM(TM) Platform and Lead RNAi-based Drug Candidates September 14th, 2017

Graphene based terahertz absorbers: Printable graphene inks enable ultrafast lasers in the terahertz range September 13th, 2017

Applications for the nanomedTAB are open until September 18th, 2017 September 13th, 2017

Discoveries

Copper catalyst yields high efficiency CO2-to-fuels conversion: Berkeley Lab scientists discover critical role of nanoparticle transformation September 20th, 2017

Solar-to-fuel system recycles CO2 to make ethanol and ethylene: Berkeley Lab advance is first demonstration of efficient, light-powered production of fuel via artificial photosynthesis September 19th, 2017

A new approach to ultrafast light pulses: Unusual fluorescent materials could be used for rapid light-based communications systems September 19th, 2017

New quantum phenomena in graphene superlattices September 18th, 2017

Announcements

GLOBALFOUNDRIES Delivers 8SW RF SOI Technology for Next-Generation Mobile and 5G Applications: Advanced 8SW 300mm SOI technology enables cost-effective, high-performance RF front-end modules for 4G LTE mobile and sub-6GHz 5G applications September 20th, 2017

GLOBALFOUNDRIES Unveils Vision and Roadmap for Next-Generation 5G Applications: Technology platforms are uniquely positioned to enable a new era of ‘connected intelligence’ with the transition to 5G September 20th, 2017

GLOBALFOUNDRIES Delivers Custom 14nm FinFET Technology for IBM Systems: Jointly developed 14HP process is world’s only technology that leverages both FinFET and SOI September 20th, 2017

GLOBALFOUNDRIES Introduces New 12nm FinFET Technology for High-Performance Applications September 20th, 2017

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project